ChemicalBook > CAS DataBase List > OCHRATOXIN B

OCHRATOXIN B

Product Name: OCHRATOXIN B
CAS No.: 4825-86-9
Chemical Name: OCHRATOXIN B
Synonyms: OCHRATOXIN B;(r)-carbonyl);Ochratoxin B(OTB);ochratoxin b solution;Ochratoxin B in Methanol;Ochratoxin B 10ug/ml in ACN;Ochratoxin B in acetonitrile;Ochratoxin B 10.0 μg/ml Acetonitrile;ochratoxin B from aspergillus ochraceus;U-[13C20]- Ochratoxin B in Acetonitrile
CBNumber: CB2297543
Molecular Formula: C20H19NO6
Formula Weight: 369.37
MOL File: 4825-86-9.mol

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OCHRATOXIN B Property

Melting point:: 221° (van der Merwe)
alpha: D -35° (c = 0.15 in ethanol)
Boiling point:: 632.4±55.0 °C(Predicted)
Density: 1.361±0.06 g/cm3(Predicted)
Flash point:: -11 °C
storage temp.: 2-8°C
solubility: DMF: 10 mg/ml; DMSO: 15 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.50 mg/ml
form: A crystalline solid
pka: 3.40±0.10(Predicted)
color: White to off-white
EPA Substance Registry System: L-Phenylalanine, N-[[(3R)-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]- (4825-86-9)

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Safety

Hazard Codes: Xn,T,F
Risk Statements: 22-36/37/38-65-48/23/24/25-36/38-11-46-45-36-20/21/22
Safety Statements: 26-36-45-16-53-36/37-62
RIDADR: UN 3462 6.1/PG 3
WGK Germany: 3
RTECS: AY6825000
HazardClass: 6.1(a)
PackingGroup: I
HS Code: 39229000
Hazardous Substances Data: 4825-86-9(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H312Harmful in contact with skin

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 32411
Product name: Ochratoxin B solution
Purity: 10?μg/mL in acetonitrile, analytical standard
Packaging: 1ML
Price: $531
Updated: 2025/07/31

Cayman Chemical

Product number: 16167
Product name: Ochratoxin B
Purity: ≥98%
Packaging: 500μg
Price: $111
Updated: 2024/03/01

Cayman Chemical

Product number: 16167
Product name: Ochratoxin B
Purity: ≥98%
Packaging: 1mg
Price: $210
Updated: 2024/03/01

Cayman Chemical

Product number: 16167
Product name: Ochratoxin B
Purity: ≥98%
Packaging: 5mg
Price: $601
Updated: 2024/03/01

Usbiological

Product number: O5305-04
Product name: Ochratoxin B
Packaging: 1mg
Price: $426
Updated: 2021/12/16

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OCHRATOXIN B Chemical Properties,Usage,Production

Description

Ochratoxins are mycotoxins produced by Aspergillus and Penicillium species of fungi that contaminate foods. Ochratoxin A (OTA, ) is a chlorinated form with toxicity that targets the kidneys, causing nephropathy and renal adenomas. OTB is a non-chlorinated analog of OTA that has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion. OTB inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 μg/ml but lacks the genotoxic activity of OTA, even at higher concentrations.

Uses

Ochratoxins are toxic metabolites from Aspergillus orchraceus.

Uses

Ochratoxin B is the non-chlorinated analogue of the much more extensively studied ochratoxin A. It is co-produced by the same species of Aspergillus and Penicillium that are associated with food spoilage. Ochratoxin B has received little focused investigation and its mode of action and potential hazards have been inferred from ochratoxin A.

Definition

ChEBI: Ochratoxin B is a phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid. Ochratoxin B differs from the more naturally abundant ochratoxin A in the absence of the dihydroisocoumarin chlorine atom. It has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion. It inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 mug/ ml but lacks the genotoxic activity of ochratoxin A, even at higher concentrations. It has a role as an Aspergillus metabolite, a Penicillium metabolite, a mycotoxin and a calcium channel blocker. It is a phenylalanine derivative, a N-acyl-L-phenylalanine, a member of isochromanes and a monocarboxylic acid. It is a conjugate acid of an ochratoxin B(1-).

General Description

Crystals that exhibit blue fluorescence.

Reactivity Profile

OCHRATOXIN B is incompatible with strong oxidizing agents, strong acids and strong bases. OCHRATOXIN B is a carboxylic acid derivative. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt.

Fire Hazard

Flash point data for OCHRATOXIN B are not available. OCHRATOXIN B is probably combustible.

References

[1] J VARGA. Ochratoxin production by Aspergillus species.[J]. Applied and Environmental Microbiology, 1996, 62 12: 4461-4464. DOI: 10.1128/aem.62.12.4461-4464.1996
[2] SIEGFRIED KNASMüLLER. Structurally related mycotoxins ochratoxin A, ochratoxin B, and citrinin differ in their genotoxic activities and in their mode of action in human-derived liver (HepG2) cells: implications for risk assessment.[J]. Nutrition and Cancer-An International Journal, 2004, 50 2: 190-197. DOI: 10.1207/s15327914nc5002_9
[3] E. O’BRIEN Daniel R D A Prietz. Investigation of the teratogenic potential of ochratoxin A and B using the FETAX system[J]. Birth defects research. Part B, Developmental and reproductive toxicology, 2005, 74 5: 417-423. DOI: 10.1002/bdrb.20054
[4] C N EZEKIEL. Fungal and bacterial metabolites in commercial poultry feed from Nigeria.[J]. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment, 2012, 29 8: 1288-1299. DOI: 10.1080/19440049.2012.688878

OCHRATOXIN B Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from OCHRATOXIN B manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Ochratoxin B 4825-86-9
Price: US $1.00-22.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-07-29

4825-86-9, OCHRATOXIN BRelated Search:

Ochratoxin A-d5 Ochratoxin A,B,C ochratoxin C Ochratoxin A13C20 solution 3-METHYLHIPPURIC ACID 3-Methylsalicylic acid 4-Methylsalicylamide OCHRATOXIN A BENZOYL-DL-PHENYLALANINE 3-FORMYLSALICYLIC ACID, 97 Salicyluric acid 4-ETHYLBENZAMIDE BZ-PHE-OH cresotamide N-(4-ETHYLBENZYL)-N-METHYLAMINE 3-Aminomethylbenzoic acid OCHRATOXIN A(RG) Methyl3-(aminomethyl)benzoate

2-[((3R)-8-HYDROXY-3-METHYL-1-OXOISOCHROMAN-7-YL)CARBONYLAMINO](2S)-3-PHENYLPR OPANOIC ACID

Ochratoxin B(OTB)

Ochratoxin B, 99%, from Aspergillus ochraceus

OCHRATOXIN B

(r)-carbonyl)

l-phenylalanine,n-((3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1h-2-benzopyran-7-yl)

N-[(8-Hydroxy-3-Methyl-1-oxo-7-isochroManyl)carbonyl]-3-phenyl-L- alanine

N-[[(3R)-3,4-Dihydro-8-hydroxy-3-Methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine

ochratoxin B from aspergillus ochraceus

ochratoxin b from aspergillus ochraceus (aspergillus oryzae)

ochratoxin b solution

(-)-N-[[(R)-3,4-Dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine

N-[[(3R)-1-Oxo-3-methyl-8-hydroxy-3,4-dihydro-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine

N-[[(R)-1-Oxo-3α-methyl-8-hydroxyisochroman-7-yl]carbonyl]-L-phenylalanine

(2S)-2-[[(3R)-8-hydroxy-1-keto-3-methyl-isochromane-7-carbonyl]amino]-3-phenyl-propionic acid

(2S)-2-[[(3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydroisochromen-7-yl]carbonylamino]-3-phenyl-propanoic acid

(2S)-2-[[(3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydroisochromene-7-carbonyl]amino]-3-phenylpropanoic acid

Ochratoxin B Solution (10μg/ml in Acetonitrile Solution)

L-Phenylalanine, N-[[(3R)-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-

Ochratoxin B 10ug/ml in ACN

(2S)-2-[[(3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydroisochromene-7-carbonyl]amino]-3-phenylpropanoicaci

Ochratoxin B in acetonitrile

Ochratoxin B in Methanol

U-[13C20]- Ochratoxin B in Acetonitrile

Ochratoxin B 10.0 μg/ml Acetonitrile

Ochratoxin A and B Mixture 592 10 μg/mL in Acetonitrile

4825-86-9

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