N2-iso-Butyroyl-2'-O-propargylguanosine

Product Name: N2-iso-Butyroyl-2'-O-propargylguanosine
CAS No.: 2095417-55-1
Chemical Name: N2-iso-Butyroyl-2'-O-propargylguanosine
Synonyms: 2'-O-propargyl-rG(iBu);N2-Isobutyryl-2'-O-propargyl-guanosine;N2-iso-Butyroyl-2’-O-propargylguanosine;N2-iso-Butyroyl-2'-O-propargylguanosine
CBNumber: CB23035270
Molecular Formula: C17H21N5O6
Formula Weight: 391.37854
MOL File: 2095417-55-1.mol

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N2-iso-Butyroyl-2'-O-propargylguanosine Property

Density: 1.56±0.1 g/cm3(Predicted)
pka: 8.68±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N2-iso-Butyroyl-2'-O-propargylguanosine Chemical Properties,Usage,Production

Uses

N2-iso-Butyroyl-2’-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. N2-iso-Butyroyl-2’-O-propargylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References

[1] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100

N2-iso-Butyroyl-2'-O-propargylguanosine Preparation Products And Raw materials

Raw materials

Preparation Products

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N2-iso-Butyroyl-2'-O-propargylguanosine Suppliers

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2095417-55-1