ChemicalBook > CAS DataBase List > Neocryptotanshinone

Neocryptotanshinone

Product Name: Neocryptotanshinone
CAS No.: 109664-02-0
Chemical Name: Neocryptotanshinone
Synonyms: Neocryptotanshinone;(R)-3-Hydroxy-2-(1-hydroxypropan-2-yl)-8,8-dimethyl-5,6,7,8-tetrahydrophenanthrene-1,4-dione;5,6,7,8-Tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-1,4-phenanthrenedione;1,4-Phenanthrenedione, 5,6,7,8-tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-
CBNumber: CB23037421
Molecular Formula: C19H22O4
Formula Weight: 314.38
MOL File: 109664-02-0.mol

Less

Neocryptotanshinone Property

Boiling point:: 517.1±50.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 4.50±1.00(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C19H22O4/c1-10(9-20)14-16(21)12-6-7-13-11(5-4-8-19(13,2)3)15(12)18(23)17(14)22/h6-7,10,20,22H,4-5,8-9H2,1-3H3/t10-/m0/s1
InChIKey: PKEGICXVZMKJPR-JTQLQIEISA-N
SMILES: C1(=O)C2=C(C3=C(C=C2)C(C)(C)CCC3)C(=O)C(O)=C1[C@@H](C)CO

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0077856
Product name: Neocryptotanshinone
Purity: 98.82%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0077856
Product name: Neocryptotanshinone
Purity: 98.82%
Packaging: 10mg
Price: $920
Updated: 2021/12/16

Arctom

Product number: CFN92181
Product name: Neocryptotanshinone
Purity: ≥98%
Packaging: 10mg
Price: $398
Updated: 2021/12/16

Less

Neocryptotanshinone Chemical Properties,Usage,Production

Uses

Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways[1][2].

in vivo

Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components)^[3].

Animal Model:	MSU-induced pain model in male ICR mice (weighing 20-25 g)^[2]
Dosage:	10, 25, 50 or 100 mg/kg
Administration:	Oral gavage; for 30, 60, 120 min
Result:	Inhibited inflammatory symptoms and nociceptive behaviors in a dose-dependent manner.

IC 50

iNOS

References

[1] Chuanhong Wu, et al. Neocryptotanshinone Inhibits Lipopolysaccharide-Induced Inflammation in RAW264.7 Macrophages by Suppression of NF-κB and iNOS Signaling Pathways. Acta Pharm Sin B. 2015 Jul;5(4):323-9. DOI:10.1016/j.apsb.2015.01.010
[2] H C Lin, et al. Two New Fatty Diterpenoids From Salvia Miltiorrhiza. J Nat Prod. 2001 May;64(5):648-50. DOI:10.1021/np000345v
[3] FENG Jinghui, et al. Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro. J Tradit Chin Med. 2021. 41(2): 219-226. PMID:33825401

Neocryptotanshinone Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Neocryptotanshinone Suppliers

China 66 United States 4 Global 70

cjbscvictory

Tel: 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10503
Advantage: 58

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20794
Advantage: 60

Shanghai ChengShao Biological Technology Co., Ltd.

Tel: 021-61847300 13341622919
Fax: 021-61847300
Email: shcss01@163.com
Country: China
ProdList: 4808
Advantage: 58

Shanghai Yihe Biological Technology Co., Ltd.

Tel: 021-68882955 17721395025
Fax: 021-68882955
Email: 2423903095@qq.com
Country: China
ProdList: 4991
Advantage: 58

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-028-85370565-229-229 18080489829
Email: 18080489829@163.com
Country: China
ProdList: 8250
Advantage: 60

Henan Alfachem Co.,Ltd.

Tel: 0371-55051623 18137891487
Fax: QQ：2853979817
Email: 2853979817@qq.com
Country: China
ProdList: 9984
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-62971590 18548936886
Fax: 010-62340519
Email: 3462612863@qq.com
Country: China
ProdList: 10063
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
Fax: 025-51191215
Email: 2399235533@qq.com
Country: China
ProdList: 4933
Advantage: 58

Hubei Ipure Biology Co., Ltd

Tel: +8613367258412
Fax: 18062427325
Email: ada@ipurechemical.com
Country: China
ProdList: 10237
Advantage: 58

HONG KONG IPURE BIOLOGY CO.,LIMITED

Tel: 86 18062405514 18062405514
Email: ada@ipurechemical.com
Country: CHINA
ProdList: 3461
Advantage: 58

Zhejiang Lianshuo Biotechnology Co., Ltd.

Tel: 18616526224
Email: lianshuo@vip.126.com
Country: China
ProdList: 9607
Advantage: 58

Shanghai Fusheng Industrial Co., LTD

Tel: 021-52961053 13524666654
Email: 3004902811@qq.com
Country: China
ProdList: 9724
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

Shanghai Hewu Biotechnology Co., LTD

Tel: 021-57886085 17317861055
Email: shhebio@126.com
Country: CHINA
ProdList: 7974
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

Henan yingchuang

Tel: 16650708709
Fax: qq:778660296
Email: hnyingchuang@163.com
Country: China
ProdList: 3965
Advantage: 58

Shanghai Taopu Industrial Co., LTD

Tel: 159-00573766 18018507602
Email: 394643792@qq.com
Country: China
ProdList: 4328
Advantage: 58

Shanghai Moqi Biological Technology Co., LTD

Tel: 021-38218169 13681877033
Email: 2702713455@qq.com
Country: China
ProdList: 9997
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175-877 18933936954
Email: tianwen.zhan@cato-chem.com
Country: China
ProdList: 7259
Advantage: 58

Naturewill Biotechnology Co., Ltd.

Tel: 028-82632533 18113192475
Email: 3157321941@qq.com
Country: China
ProdList: 4993
Advantage: 58

G-CLONE

Tel: 400-910-1997 15330005590
Email: 3546414794@qq.com
Country: China
ProdList: 9959
Advantage: 58

Shandong Mopai Biotechnology Co., Ltd

Tel: 13053322091
Email: admin@mopaikeji.com
Country: China
ProdList: 5813
Advantage: 58

Shanghai Yanchun Biopharmaceutical Technology Co., Ltd

Tel: 4001-009266 17349750668
Email: product@sci-e.com
Country: China
ProdList: 2808
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: rose.shi@synzest.com
Country: China
ProdList: 6210
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Hubei CuiRan Biotechnology Co., Ltd.

Tel: 00-1816279-5156 18162795156
Email: 3391961471@qq.com
Country: China
ProdList: 4332
Advantage: 58

RENI Pharmaceutical Technology Co., Ltd

Tel: 028-87865381 18108190480
Email: 2881944542@qq.com
Country: China
ProdList: 3308
Advantage: 58

Mensura Group Limited

Tel: 17318633522
Fax: 028-87362290
Email: 18109034517@163.com
Country: China
ProdList: 2898
Advantage: 58

Chengdu DeSiTe Biological Technology Co., Ltd

Tel: 17308096051
Email: 3001048290@qq.com
Country: China
ProdList: 6219
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Chengdu Biopurify Ltd.

Tel: 28-82633860 18982077548
Email: cwb1@biopurify.cn
Country: China
ProdList: 3842
Advantage: 58

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-28-82633860; +8618080483897
Email: sales@biopurify.com
Country: China
ProdList: 3751
Advantage: 58

Mensura Group Limited

Tel: 18780014153
Fax: 028-87362290
Email: 1058503172@qq.com
Country: China
ProdList: 2900
Advantage: 58

SHANGHAI KEAN TECHNOLOGY CO., LTD.

Tel: +8613817748580
Fax: 021-50175322
Email: cooperation@kean-chem.com
Country: China
ProdList: 40066
Advantage: 58

Shanghai Acmec Biochemical Technology Co., Ltd.

Tel: +86-18621343501; +undefined18621343501
Email: product@acmec-e.com
Country: China
ProdList: 33338
Advantage: 58

Shanghai Ruili Spectrum Biotechnology Co., Ltd

Tel: 021-64705760 18027310741
Email: 1060496435@qq.com
Country: China
ProdList: 4566
Advantage: 58

Jiangxi Longcheng Shuangfeng Technology Co., Ltd.

Tel: 18170904889
Country: CHINA
ProdList: 147
Advantage: 58

Guangzhou Suyan Biotechnology Co., Ltd

Tel: 18818417021
Country: CHINA
ProdList: 127
Advantage: 58

Guangzhou Zhuanyan Biotechnology Co., Ltd.

Tel: 18926165828
Country: CHINA
ProdList: 198
Advantage: 58

Guangzhou Kangkaixin Biotechnology Co., Ltd.

Tel: 13760798286
Country: CHINA
ProdList: 188
Advantage: 58

109664-02-0, NeocryptotanshinoneRelated Search:

Tanshinone IIA Salvianolic acid Salvianolicacid C 3-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid magnessium lithospermate B 9'''-MethyllithosperMate B 9'''-MethyllithosperMate B Sodium danshensu TanshinoneIIA 7-Ethyl-10-hydroxycamptothecin 5,6,7,8-Tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-1,4-phenanthrenedione 1,2-Didehydrocryptotanshinone (8S)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione TANSHINONE ⅡA Cryptotanshinone

Neocryptotanshinone

5,6,7,8-Tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-1,4-phenanthrenedione

1,4-Phenanthrenedione, 5,6,7,8-tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-

(R)-3-Hydroxy-2-(1-hydroxypropan-2-yl)-8,8-dimethyl-5,6,7,8-tetrahydrophenanthrene-1,4-dione

109664-02-0