ChemicalBook > CAS DataBase List > Pefloxacin

Pefloxacin

Product Name
Pefloxacin
CAS No.
70458-92-3
Chemical Name
Pefloxacin
Synonyms
am725;1584rb;am-725;1589RB;RB-1589;EU-5306;Penaeine;peflacin;PEFLOXACIN;Penoxacine
CBNumber
CB2304155
Molecular Formula
C17H20FN3O3
Formula Weight
333.36
MOL File
70458-92-3.mol
More
Less

Pefloxacin Property

Melting point:
270-272° (dec)
Boiling point:
529.1±50.0 °C(Predicted)
Density 
1.320±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
pka
0.16±0.20(Predicted)
CAS DataBase Reference
70458-92-3(CAS DataBase Reference)
More
Less

Safety

Toxicity
LD50 in mice (mg/kg): 225 i.v., 1000 orally; in rats (g/kg): 1.5 i.p., 2.5 orally (Goueffon)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P0106
Product name
Pefloxacin mesylate dihydrate
Packaging
10 g
Price
$60.4
Updated
2021/12/16
Usbiological
Product number
241178
Product name
Pefloxacin
Packaging
1g
Price
$156
Updated
2021/12/16
Usbiological
Product number
462119
Product name
Pefloxacin Mesylate Dihydrate
Packaging
5g
Price
$305
Updated
2021/12/16
Usbiological
Product number
287889
Product name
Pefloxacin
Packaging
25g
Price
$398
Updated
2021/12/16
TRC
Product number
P218350
Product name
Pefloxacinium
Packaging
1g
Price
$670
Updated
2021/12/16
More
Less

Pefloxacin Chemical Properties,Usage,Production

Uses

antibacterial;DNA gyrase inhibitor

Definition

ChEBI: A quinolone that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6 and 7 by ethyl, carboxy, fluorine, and 4-methylpiperazin-1-yl groups, respectively.

Pharmaceutical Applications

A 6-fluoro, 7-piperazinyl quinoline available for oral and intravenous administration. The in-vitro activity is very similar to that of norfloxacin . It is active against H. ducreyi, V. cholerae and Legionella spp., but Campylobacter and Acinetobacter spp. and pseudomonads are not susceptible. It has poor activity against pneumococci, chlamydiae, mycoplasmas and ureaplasmas. L. monocytogenes, Nocardia spp. and anaerobes are resistant.
A plasma concentration of c. 5 mg/L is achieved 1–1.5 h after a 400 mg oral dose. The plasma elimination half-life is 8.5–15 h. It is widely distributed, concentrations in bone, brain, blister fluid, CSF, saliva, sputum and prostate all approximating, and in some cases exceeding, the simultaneous plasma concentration. It is extensively metabolized to the desmethyl (= norfloxacin) and N-oxide derivatives. Some 60–70% of a dose, only about 10% of which is unchanged, appears in the urine; 25% of a dose appears in the feces, a small part contributed by elimination in the bile.
The half-life increases with hepatic impairment, but is virtually unaffected by renal failure. In patients on continuous ambulatory peritoneal dialysis (CAPD) given 800 mg followed by 400 mg every 12 h for 10–12 days, there was no significant accumulation of pefloxacin or its metabolite, norfloxacin, but concentrations of pefloxacin N-oxide rose continuously in plasma and dialysate; all concentrations fell rapidly when treatment was discontinued.
Adverse reactions are those common to the group . Most common are gastrointestinal tract disturbances, although some typical CNS reactions have been encountered. Skin eruptions (some photosensitive) occur and rashes appeared in about one-third of a group of patients who were given longterm therapy. Clinical uses are similar to those of ofloxacin.

Pefloxacin Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Pefloxacin Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
1938
Advantage
70
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005;021-58099637-8009
Fax
021-58099609
Email
bin.wu@shlschem.com;sales@shlschem.com
Country
China
ProdList
9827
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20007
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
;021-54306202- ;
Fax
13764082696
Email
jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com
Country
China
ProdList
43059
Advantage
64
BOC Sciences
Email
info@bocsci.com
Country
United States
ProdList
21113
Advantage
65
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725;010-86181995
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12341
Advantage
58
MedChemexpress LLC
Tel
609-228-6898
Fax
609-228-5909
Email
sales@medchemexpress.com
Country
United States
ProdList
4788
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810- ;025-57798810-
Fax
025-57019371
Email
sales@sunlidabio.com;sales@sunlidabio.com
Country
China
ProdList
3756
Advantage
55
TianJin Alta Scientific Co., Ltd.
Tel
+86-022-6537-8550
Fax
+86-022-2532-9655
Email
contact@altascientific.com
Country
China
ProdList
2775
Advantage
58
More
Less

View Lastest Price from Pefloxacin manufacturers

Hebei Crovell Biotech Co Ltd
Product
Pefloxacin 70458-92-3
Price
US $10.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
1 ton
Release date
2021-07-06
Dideu Industries Group Limited
Product
Pefloxacin USP/EP/BP 70458-92-3
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-20
Shaanxi Dideu Medichem Co. Ltd
Product
Perfloxacin 70458-92-3
Price
US $0.01-1.00/KG
Min. Order
1ASSAYS
Purity
99%
Supply Ability
50 tons
Release date
2020-05-13

70458-92-3, PefloxacinRelated Search:


  • 1-Ethyl-4-oxo-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid
  • 1-Ethyl-6-fluoro-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-quinolinecarboxylic acid
  • 1-Ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
  • N-Methylnorfloxacin
  • SULPHONATE DIHYDRATE
  • RB-1589
  • PEFLOXACIN
  • PEFLOXACINE MESYLATE DIHYDRATE
  • PEFLOXACINE METHANSULFONATE DIHYDRATE
  • PEFLOXACIN MESYLATE DIHYDRATE
  • PEFLOXACIN METHANESULFONATE
  • PEFLOXACIN METHANE SULFONATE DIHYDRATE
  • PERFLOXACINE
  • 1584rb
  • 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methyl-1-piperazinyl)-3-quinolinecar
  • Penaeine
  • Penoxacine
  • 1-Ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
  • 3-quinolinecarboxylicacid,1,4-dihydro-1-ethyl-6-fluoro-7-(4-methyl-1-piperazi
  • am725
  • am-725
  • nyl)-4-oxo-
  • EU-5306
  • 1-ETHYL-6-FLUORO-1,4-DIHYDRO-7-(4-METHYL-1-PIPERAZINYL-4-OXO-3-QUINOLINE CARBOXYLIC ACID) METHANE SULPHONATE DIHYDRATE
  • 1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID
  • PEFLOXACIN(SUBJECTTOPATENTFREE)
  • pefloxacine
  • peflacin
  • PEFLOXACIN MESYLATE 99%
  • 1,4-Didhydro-7(4-methylpiperazinyl)-fluoro-1-ethyl-4-oxosynolin carbonoic acid
  • 1589mRB:Peflox
  • 1589RB
  • 1-Ethyl-1,4-dihydro-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
  • Pefloxacinium
  • 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-
  • Pefloxacin USP/EP/BP
  • 70458-92-3
  • C17H20FN3O3