Mal-PEG1-NHS ester
- Product Name
- Mal-PEG1-NHS ester
- CAS No.
- 1807518-72-4
- Chemical Name
- Mal-PEG1-NHS ester
- Synonyms
- MAL-PEG1-NHS;Mal-PEG1-SPA;CAS_1807518-72-4;Mal-PEG1-NHS ester;Mal-PEG1-CH2CH2COONHS;2,5-Dioxopyrrolidin-1-yl 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoate;2,5-dioxypyrolidine-1-yl3-(2-(2,5-dioxy-2,5-dihydro-1H-pyridine-1-yl)ethoxy)propanoic acidester;Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester;PROTAC,Antibody-drug conjugates linkers,Inhibitor,inhibit,PROTAC Linkers,Mal-PEG-1-NHS ester,PEG,Linker,ADC Linkers,Mal PEG1 NHS ester,ADC,MalPEG1NHS ester
- CBNumber
- CB23062526
- Molecular Formula
- C13H14N2O7
- Formula Weight
- 310.26
- MOL File
- 1807518-72-4.mol
Mal-PEG1-NHS ester Property
- Boiling point:
- 488.4±55.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- solubility
- Soluble in DCM
- pka
- -2.35±0.20(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1S/C13H14N2O7/c16-9-1-2-10(17)14(9)6-8-21-7-5-13(20)22-15-11(18)3-4-12(15)19/h1-2H,3-8H2
- InChIKey
- AMRJPIJPLBUEHO-UHFFFAOYSA-N
- SMILES
- C(ON1C(=O)CCC1=O)(=O)CCOCCN1C(=O)C=CC1=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- BP-21854
- Product name
- Mal-PEG1-NHSester
- Purity
- 98%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- BP-21854
- Product name
- Mal-PEG1-NHSester
- Purity
- 98%
- Packaging
- 250mg
- Price
- $560
- Updated
- 2021/12/16
- Product number
- BIPG1502
- Product name
- Mal-PEG1-NHS ester
- Packaging
- 100mg
- Price
- $623
- Updated
- 2021/12/16
- Product number
- BP-21854
- Product name
- Mal-PEG1-NHSester
- Purity
- 98%
- Packaging
- 500mg
- Price
- $890
- Updated
- 2021/12/16
- Product number
- CS-0107986
- Product name
- Mal-PEG1-NHSester
- Packaging
- 250mg
- Price
- $1700
- Updated
- 2021/12/16
Mal-PEG1-NHS ester Chemical Properties,Usage,Production
Description
Mal-PEG1-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Biological Activity
Mal-PEG1-NHS ester is a cleavable PEG-based ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PEG-based PROTAC linker that can be used to synthesize PROTACs.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
|