GW806742X

Product Name: GW806742X
CAS No.: 579515-63-2
Chemical Name: GW806742X
Synonyms: CS-2659;GW806742X;GW806742X ≥95%;GW806742X >=98% (HPLC);GW806742X;GW-806742X;GW 806742X;1-[4-[methyl-[2-(3-sulfamoylanilino)pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethoxy)phenyl]urea;3-((4-(Methyl(4-(3-(4-(trifluoromethoxy)phenyl)ureido)phenyl)amino)pyrimidin-2-yl)amino)benzenesulfonamide;3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]-benzenesulfonamide;Benzenesulfonamide, 3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]-;VEGFR,death,GW806742X,translocation,GW-806742X,Vascular endothelial growth factor receptor,membrane,Inhibitor,TSQ,MLKs,inhibit,HUVEC,Mixed Lineage Kinase,necroptotic
CBNumber: CB23067556
Molecular Formula: C25H22F3N7O4S
Formula Weight: 573.55
MOL File: 579515-63-2.mol

More

Less

GW806742X Property

Density: 1.524±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);174.35(Max Conc. mM)
form: Solid
pka: 10.09±0.60(Predicted)
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1990
Product name: GW806742X
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $131
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1990
Product name: GW806742X
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $530
Updated: 2024/03/01

Adipogen Life Sciences

Product number: SYN-1215-M050
Product name: GW806742X
Purity: ≥95%
Packaging: 50mg
Price: $918
Updated: 2021/12/16

AK Scientific

Product number: SYN1215
Product name: GW806742X
Packaging: 10mg
Price: $340
Updated: 2021/12/16

ChemScene

Product number: CS-0044745
Product name: GW806742X
Purity: 98.09%
Packaging: 100mg
Price: $450
Updated: 2021/12/16

More

Less

GW806742X Chemical Properties,Usage,Production

Biological Activity

GW806742X, an ATP mimetic, is a potent MLKL inhibitor that binds the MLKL pseudokinase domain with a Kd of 9.3μM. It has anti-VEGFR2 activity (IC50=2 nM). It delays MLKL membrane translocation and inhibits necrosis.

in vitro

GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD -OPh) in a dose-dependent manner. GW806742X shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM.

target

MLKL

9.3 μM (Kd)

VEGFR2

2 nM (IC _{50 < /sub> )}

GW806742X Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

GW806742X Suppliers

China 48 United Kingdom 1 United States 6 Global 55

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

579515-63-2, GW806742XRelated Search:

GW 4064 GW843682, 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide GW-6604 Carbamic acid, N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-, phenylmethyl ester GW 627368X GW 6471

GW806742X

CS-2659

GW806742X;GW-806742X;GW 806742X

1-[4-[methyl-[2-(3-sulfamoylanilino)pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethoxy)phenyl]urea

GW806742X ≥95%

Benzenesulfonamide, 3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]-

GW806742X >=98% (HPLC)

3-((4-(Methyl(4-(3-(4-(trifluoromethoxy)phenyl)ureido)phenyl)amino)pyrimidin-2-yl)amino)benzenesulfonamide

VEGFR,death,GW806742X,translocation,GW-806742X,Vascular endothelial growth factor receptor,membrane,Inhibitor,TSQ,MLKs,inhibit,HUVEC,Mixed Lineage Kinase,necroptotic

3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]-benzenesulfonamide

579515-63-2

C25H22F3N7O4S