Methyl 4-chloro-3-formylbenzoate
- Product Name
- Methyl 4-chloro-3-formylbenzoate
- CAS No.
- 1044920-98-0
- Chemical Name
- Methyl 4-chloro-3-formylbenzoate
- Synonyms
- Methyl 4-chloro-3-formylbenzoate;Benzoic acid, 4-chloro-3-formyl-, methyl ester
- CBNumber
- CB23119170
- Molecular Formula
- C9H7ClO3
- Formula Weight
- 198.6
- MOL File
- 1044920-98-0.mol
Methyl 4-chloro-3-formylbenzoate Property
- Boiling point:
- 295.8±25.0 °C(Predicted)
- Density
- 1.315±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B495168
- Product name
- Methyl4-Chloro-3-formylbenzoate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 1644DL
- Product name
- Methyl4-chloro-3-formylbenzoate
- Packaging
- 10g
- Price
- $3866
- Updated
- 2021/12/16
- Product number
- A183908
- Product name
- Methyl4-chloro-3-formylbenzoate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $29
- Updated
- 2021/12/16
- Product number
- A183908
- Product name
- Methyl4-chloro-3-formylbenzoate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $44
- Updated
- 2021/12/16
- Product number
- A183908
- Product name
- Methyl4-chloro-3-formylbenzoate
- Purity
- 95%
- Packaging
- 1g
- Price
- $128
- Updated
- 2021/12/16
Methyl 4-chloro-3-formylbenzoate Chemical Properties,Usage,Production
Synthesis
91367-05-4
1044920-98-0
General procedure for the synthesis of methyl 4-chloro-3-formylbenzoate from methyl 4-chloro-3-methylbenzoate: a mixture of 17.0 mL of glacial acetic acid, 16.5 mL of acetic anhydride, and 2.5 mL of concentrated sulfuric acid was cooled in an ice bath. Subsequently, 1.84 g (0.01 mol) of methyl 4-chloro-3-methylbenzoate and 3 g of chromium trioxide (0.03 mol) were added in batches. The reaction mixture was stirred in an ice bath for 3 hours. Upon completion of the reaction, the reaction solution was slowly poured into 200.0 mL of ice water and stirred vigorously for 30 minutes. The resulting gray solid precipitate was collected by filtration and washed three times with 70.0 mL of water. The resulting solid was transferred to a 50.0 mL aubergine flask, 16.0 mL methanol, 16.0 mL water and 0.4 mL concentrated sulfuric acid were added and refluxed for 30 minutes. After the reaction, the residue was poured into water and the aqueous layer was extracted with ethyl acetate (3 x 100 mL). The ethyl acetate extracts were combined and washed sequentially with 80 mL of water and 80 mL of saturated saline, then dried with anhydrous sodium sulfate. After evaporation of the solvent, 1.35 g (yield 68.2%) of the yellow solid product methyl 4-chloro-3-formylbenzoate was obtained. Melting point: 131-133 °C. 1H NMR (300 MHz, DMSO-d6) δ: 3.90 (s, 3H, OCH3), 7.79 (d, 1H, Ar-H, J = 8.4 Hz), 8.18 (d, 1H, Ar-H, J = 8.4 Hz), 8.35 (s, 1H, Ar-H), 10.34 (s, 1H, CHO) IR (KBr, cm-1): 3425, 3082, 3003, 2953, 1726, 1720, 1689, 1188, 983, 759.MS [M + H]+: 199.1.
References
[1] European Journal of Medicinal Chemistry, 2015, vol. 90, p. 170 - 183
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 24, p. 10188 - 10204
Methyl 4-chloro-3-formylbenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 4-chloro-3-formylbenzoate manufacturers
- Product
- Methyl 4-chloro-3-formylbenzoate 1044920-98-0
- Price
- US $101.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-28