4-CHLORO-3-CYANOMETHYL-BENZOIC ACID METHYL ESTER

Product Name: 4-CHLORO-3-CYANOMETHYL-BENZOIC ACID METHYL ESTER
CAS No.: 872091-83-3
Chemical Name: 4-CHLORO-3-CYANOMETHYL-BENZOIC ACID METHYL ESTER
Synonyms: 3-Cyanomethyl-4-chlorobenzoic acid methyl ester;4-CHLORO-3-CYANOMETHYL-BENZOIC ACID METHYL ESTER;Methyl 4-chloro-3-(cyanomethyl)benzoate - [M71997];3-Cyanomethyl-4-Chorobenzoic Acid Methyl Ester (en);Benzoic acid, 4-chloro-3-(cyanomethyl)-, methyl ester
CBNumber: CB11092669
Molecular Formula: C10H8ClNO2
Formula Weight: 209.63
MOL File: 872091-83-3.mol

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4-CHLORO-3-CYANOMETHYL-BENZOIC ACID METHYL ESTER Property

Density: 1.266
storage temp.: Inert atmosphere,Room Temperature
Appearance: White to off-white Solid

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Safety

HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: M342988
Product name: Methyl4-chloro-3-(cyanomethyl)benzoate
Packaging: 100mg
Price: $175
Updated: 2021/12/16

AK Scientific

Product number: X2842
Product name: Methyl4-chloro-3-(cyanomethyl)benzoate
Packaging: 5g
Price: $158
Updated: 2021/12/16

AK Scientific

Product number: X2842
Product name: Methyl4-chloro-3-(cyanomethyl)benzoate
Packaging: 10g
Price: $211
Updated: 2021/12/16

ChemScene

Product number: CS-0045070
Product name: Methyl4-chloro-3-(cyanomethyl)benzoate
Packaging: 25g
Price: $328
Updated: 2021/12/16

ChemScene

Product number: CS-0045070
Product name: Methyl4-chloro-3-(cyanomethyl)benzoate
Packaging: 1g
Price: $37
Updated: 2021/12/16

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4-CHLORO-3-CYANOMETHYL-BENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production

Synthesis

220464-68-6

7677-24-9

872091-83-3

Step 2: Synthesis of intermediate 2 A mixture of Intermediate 1 (methyl 3-(bromomethyl)-4-chlorobenzoate, 1.00 g, 3.80 mmol), trimethylcyanosilane (TMSCN, 0.56 g, 5.69 mmol), and potassium carbonate (K2CO3, 786 mg, 5.69 mmol) in acetonitrile (CH3CN, 50 mL) was heated to reflux for 16 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered to remove insoluble material and the filtrate was concentrated. The resulting crude product was purified by silica gel column chromatography using a hexane solution of 5-10% ethyl acetate (EtOAc) as eluent to afford the target product methyl 3-cyanomethyl-4-chlorobenzoate (590 mg, 75% yield) as a white solid. 1H NMR (400 MHz, CDCl3) δ: 8.18 (d, 1H), 7.99 (dd, 1H), 7.52 (d, 1H), 3.94 (s, 3H), 3.88 (s, 2H).

References

[1] Patent: WO2014/144737, 2014, A1. Location in patent: Paragraph 00777

4-CHLORO-3-CYANOMETHYL-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-3-CYANOMETHYL-BENZOIC ACID METHYL ESTER Suppliers

China 44 India 2 United Kingdom 1 United States 3 Global 50

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872091-83-3, 4-CHLORO-3-CYANOMETHYL-BENZOIC ACID METHYL ESTERRelated Search:

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4-CHLORO-3-CYANOMETHYL-BENZOIC ACID METHYL ESTER

3-Cyanomethyl-4-chlorobenzoic acid methyl ester

3-Cyanomethyl-4-Chorobenzoic Acid Methyl Ester (en)

Benzoic acid, 4-chloro-3-(cyanomethyl)-, methyl ester

Methyl 4-chloro-3-(cyanomethyl)benzoate - [M71997]

872091-83-3