4-Chloro-2-iodo-benzoic acid Methyl ester
- Product Name
- 4-Chloro-2-iodo-benzoic acid Methyl ester
- CAS No.
- 181765-85-5
- Chemical Name
- 4-Chloro-2-iodo-benzoic acid Methyl ester
- Synonyms
- methyl 2-iodo 4-chlorobenzoate;4-Chloro-2-iodo-benzoic acid Methyl ester;benzoic acid, 4-chloro-2-iodo-, methyl ester
- CBNumber
- CB52671663
- Molecular Formula
- C8H6ClIO2
- Formula Weight
- 296.49
- MOL File
- 181765-85-5.mol
4-Chloro-2-iodo-benzoic acid Methyl ester Property
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Appearance
- Off-white to yellow Solid
N-Bromosuccinimide Price
- Product number
- Y6099
- Product name
- Methyl4-chloro-2-iodobenzoate
- Packaging
- 1g
- Price
- $167
- Updated
- 2021/12/16
- Product number
- CS-0041112
- Product name
- Methyl4-chloro-2-iodobenzoate
- Purity
- 99.66%
- Packaging
- 5g
- Price
- $421
- Updated
- 2021/12/16
- Product number
- Y6099
- Product name
- Methyl4-chloro-2-iodobenzoate
- Packaging
- 250mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- AK201245
- Product name
- Methyl4-chloro-2-iodobenzoate
- Purity
- 97%
- Packaging
- 1g
- Price
- $93
- Updated
- 2021/12/16
- Product number
- CS-0041112
- Product name
- Methyl4-chloro-2-iodobenzoate
- Purity
- 99.66%
- Packaging
- 1g
- Price
- $113
- Updated
- 2021/12/16
4-Chloro-2-iodo-benzoic acid Methyl ester Chemical Properties,Usage,Production
Synthesis
67-56-1
13421-13-1
181765-85-5
GENERAL PROCEDURE: To a stirred solution of 4-chloro-2-iodobenzoic acid (1.0 eq.) dissolved in anhydrous methanol (2.0 mL/1.0 mmol of 4-chloro-2-iodobenzoic acid) was added sulfinyl chloride (2.0 eq.) dropwise at 0 °C. After addition, the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the crude product was concentrated under reduced pressure, quenched with water and extracted with ethyl acetate. The organic layers were combined, washed with saturated aqueous sodium bicarbonate, dried over anhydrous sodium sulfate, concentrated by rotary evaporation, and finally purified by column chromatography to afford the target product methyl 4-chloro-2-iodobenzoate.
References
[1] Antimicrobial Agents and Chemotherapy, 2016, vol. 60, # 7, p. 3980 - 3987
[2] Patent: US2015/105351, 2015, A1. Location in patent: Paragraph 0451
[3] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 11, p. 1259 - 1262
4-Chloro-2-iodo-benzoic acid Methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-2-iodo-benzoic acid Methyl ester Suppliers
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