PI4KIII beta inhibitor 1

Product Name: PI4KIII beta inhibitor 1
CAS No.: 1881233-39-1
Chemical Name: PI4KIII beta inhibitor 1
Synonyms: CAS:1881233-39-1;PI4KIIIbeta-IN-10;PI4KIII beta inhibitor 1;PI4KIII beta inhibitor 10;PI4KIIIbeta-IN-10, 10 mM in DMSO;N-(5-(3-(N-(4-HYDROXYPHENYL)SULFAMOYL)-4-METHOXYPHENYL)-4-METHYLTHIAZOL-2-YL)PIVALAMIDE;N-[5-[3-[(4-hydroxyphenyl)sulfamoyl]-4-methoxyphenyl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide;PI4KIIIbeta-IN-10 (N-(5-(3-(N-(4-hydroxyphenyl)sulfamoyl)-4-methoxyphenyl)-4-methylthiazol-2-yl)pivalamide);Propanamide, N-[5-[3-[[(4-hydroxyphenyl)amino]sulfonyl]-4-methoxyphenyl]-4-methyl-2-thiazolyl]-2,2-dimethyl-;inhibit,Phosphatidylinositol 4 kinases,Inhibitor,PI4 kinases,PI4K,PI4KIIIbetaIN10,PI-4KIIIbeta-IN-10,PI4KIIIbeta IN 10
CBNumber: CB23122932
Molecular Formula: C22H25N3O5S2
Formula Weight: 475.58
MOL File: 1881233-39-1.mol

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PI4KIII beta inhibitor 1 Property

Density: 1.367±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 30 mg/mL (63.08 mM)
form: Solid
pka: 9.06±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5601
Product name: PI4KIIIbeta-IN-10
Purity: 99.84%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-5601
Product name: PI4KIIIbeta-IN-10
Purity: 99.84%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

AK Scientific

Product number: 9290DU
Product name: pi4KIIIbeta-IN-10
Packaging: 1mg
Price: $441
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611434
Product name: PI4KIIIbeta-IN-10
Packaging: 5mg
Price: $569.5
Updated: 2021/12/16

ChemScene

Product number: CS-5601
Product name: PI4KIIIbeta-IN-10
Purity: 99.84%
Packaging: 10mg
Price: $660
Updated: 2021/12/16

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PI4KIII beta inhibitor 1 Chemical Properties,Usage,Production

Uses

PI4KIIIbeta-IN-10 is a potent PI4KIIIβ inhibitor with an IC50 of 3.6 nM.

Biological Activity

PI4KIII beta inhibitor 1 is a potent PI4KIIIβ inhibitor with IC50 of 3.6 nM.

in vitro

PI4KIII beta inhibitor 1 is a potent PI4KIIIβ inhibitor with very minor off-target inhibition of PI4KIIIβ related lipid kinases. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC _{50 < /sub> ~1 μM), PI3Kα (~10 μM), and PI4KIIIα (~3 μM), and <20% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ.}

target

PI4KIIIβ

3.6 nM (IC ₅₀ )

PI4KIIIα

3 μM (IC ₅₀ )

PI3Kδ

720 nM (IC ₅₀ )

PI3KC2γ

1 μM ( IC ₅₀ )

PI3Kα

10 μM (IC ₅₀ )

PI3Kγ

20 μM (IC < sub> 50 )

IC 50

PI4KIIIβ: 3.6 nM (IC₅₀); PI4KIIIα: 3 μM (IC₅₀); PI3Kδ: 720 nM (IC₅₀); PI3KC2γ: 1 μM (IC₅₀); PI3Kα: 10 μM (IC₅₀); PI3Kγ: 20 μM (IC₅₀)

References

[1] Rutaganira FU, et al. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. J Med Chem. 2016 Mar 10;59(5):1830-9. DOI:10.1021/acs.jmedchem.5b01311

PI4KIII beta inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PI4KIII beta inhibitor 1 Suppliers

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1881233-39-1, PI4KIII beta inhibitor 1Related Search:

PI4KIIIbeta-IN-9

PI4KIII beta inhibitor 1

PI4KIIIbeta-IN-10

N-[5-[3-[(4-hydroxyphenyl)sulfamoyl]-4-methoxyphenyl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide

N-(5-(3-(N-(4-HYDROXYPHENYL)SULFAMOYL)-4-METHOXYPHENYL)-4-METHYLTHIAZOL-2-YL)PIVALAMIDE

Propanamide, N-[5-[3-[[(4-hydroxyphenyl)amino]sulfonyl]-4-methoxyphenyl]-4-methyl-2-thiazolyl]-2,2-dimethyl-

PI4KIII beta inhibitor 10

inhibit,Phosphatidylinositol 4 kinases,Inhibitor,PI4 kinases,PI4K,PI4KIIIbetaIN10,PI-4KIIIbeta-IN-10,PI4KIIIbeta IN 10

PI4KIIIbeta-IN-10, 10 mM in DMSO

CAS:1881233-39-1

PI4KIIIbeta-IN-10 (N-(5-(3-(N-(4-hydroxyphenyl)sulfamoyl)-4-methoxyphenyl)-4-methylthiazol-2-yl)pivalamide)

1881233-39-1