ChemicalBook > CAS DataBase List > 5-BROMO-2-METHOXY-NICOTINIC ACID

5-BROMO-2-METHOXY-NICOTINIC ACID

Product Name: 5-BROMO-2-METHOXY-NICOTINIC ACID
CAS No.: 54916-66-4
Chemical Name: 5-BROMO-2-METHOXY-NICOTINIC ACID
Synonyms: Zinc04352712;5-Bromo-2-methoxynic;5-Bromo-2-methoxynicotinicAci;2-Methoxy-5-bromoinicotinic acid;5-BROMO-2-METHOXY-NICOTINIC ACID;5-Bromo-2-methoxynicotinic acid 98%;5-Bromo-2-methoxypyridine-3-carboxylic acid;5-BROMO-2-METHOXY-3-PYRIDINECARBOXYLIC ACID;3-Pyridinecarboxylic acid, 5-bromo-2-methoxy-;5-BROMO-2-METHOXY-NICOTINIC ACID ISO 9001：2015 REACH
CBNumber: CB2313227
Molecular Formula: C7H6BrNO3
Formula Weight: 232.03
MOL File: 54916-66-4.mol

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5-BROMO-2-METHOXY-NICOTINIC ACID Property

Melting point:: 156-158
Boiling point:: 324.8±42.0 °C(Predicted)
Density: 1.713
storage temp.: Inert atmosphere,Room Temperature
pka: 2.97±0.10(Predicted)
form: solid
Appearance: White to off-white Solid
InChI: InChI=1S/C7H6BrNO3/c1-12-6-5(7(10)11)2-4(8)3-9-6/h2-3H,1H3,(H,10,11)
InChIKey: SJLXURQPRRMPIV-UHFFFAOYSA-N
SMILES: C1(OC)=NC=C(Br)C=C1C(O)=O
CAS DataBase Reference: 54916-66-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
WGK Germany: nwg
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 725250
Product name: 5-Bromo-2-methoxypyridine-3-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $103
Updated: 2023/06/20

TRC

Product number: B696755
Product name: 5-Bromo-2-methoxynicotinicacid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B696755
Product name: 5-Bromo-2-methoxynicotinicacid
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B696755
Product name: 5-Bromo-2-methoxynicotinicacid
Packaging: 1g
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 023784
Product name: 5-Bromo-2-methoxy-nicotinic acid
Purity: 99%
Packaging: 5g
Price: $45
Updated: 2021/12/16

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5-BROMO-2-METHOXY-NICOTINIC ACID Chemical Properties,Usage,Production

Uses

5-Bromo-2-methoxy-nicotinic acid is used as an intermediate in pharmaceutical synthesis and can be employed to prepare RXFP1 receptor agonists. Its synthetic products can selectively activate the RXFP1 receptor for the treatment of heart failure, with an EC50 value of approximately 6.3nM.

Synthesis

16498-81-0

54916-66-4

General procedure for the synthesis of 5-bromo-2-methoxynicotinic acid from 2-methoxynicotinic acid: 2-methoxynicotinic acid (20 g, 130.60 mmol) was dissolved in H2O (1500 mL) at room temperature, followed by slow addition of Br2 (20 mL, 375.45 mmol). The reaction mixture was stirred continuously at room temperature overnight. Upon completion of the reaction, the solid product was collected by filtration and washed thoroughly with deionized water and finally dried to afford 5-bromo-2-methoxynicotinic acid (25 g, 82% yield). The structure of the product was confirmed by 1H-NMR (DMSO-d6, 400 MHz) and mass spectrometry (MS): 1H-NMR δ 13.33 (br s, 1H), 8.47 (d, J = 2.4 Hz, 1H), 8.21 (d, J = 2.4 Hz, 1H), 3.90 (s, 3H); MS (M + H)+ m/z: 232/234.

References

[1] Patent: WO2013/33971, 2013, A1. Location in patent: Page/Page column 144
[2] Patent: US2014/213571, 2014, A1. Location in patent: Paragraph 0572

5-BROMO-2-METHOXY-NICOTINIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-2-METHOXY-NICOTINIC ACID Suppliers

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View Lastest Price from 5-BROMO-2-METHOXY-NICOTINIC ACID manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 5-Bromo-2-methoxynicotinic acid 54916-66-4
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-06

Dideu Industries Group Limited

Product: 5-BROMO-2-METHOXY-NICOTINIC ACID 54916-66-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-25

Career Henan Chemical Co

Product: 5-BROMO-2-METHOXY-NICOTINIC ACID 54916-66-4
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-31

54916-66-4, 5-BROMO-2-METHOXY-NICOTINIC ACIDRelated Search:

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5-BROMO-2-METHOXY-3-PYRIDINECARBOXYLIC ACID

5-BROMO-2-METHOXY-NICOTINIC ACID

5-Bromo-2-methoxypyridine-3-carboxylic acid

5-Bromo-2-methoxynicotinic acid 98%

Zinc04352712

5-Bromo-2-methoxypyridine-3-carboxylic acid, 5-Bromo-3-carboxy-2-methoxypyridine

3-Pyridinecarboxylic acid, 5-bromo-2-methoxy-

5-BROMO-2-METHOXY-NICOTINIC ACID ISO 9001：2015 REACH

5-Bromo-2-methoxynic

2-Methoxy-5-bromoinicotinic acid

5-Bromo-2-methoxynicotinicAci

54916-66-4

Carboxylic Acids

blocks

Bromides

Carboxes

Pyridines