5-BROMO-2-METHOXY-NICOTINIC ACID
- Product Name
- 5-BROMO-2-METHOXY-NICOTINIC ACID
- CAS No.
- 54916-66-4
- Chemical Name
- 5-BROMO-2-METHOXY-NICOTINIC ACID
- Synonyms
- Zinc04352712;5-Bromo-2-methoxynic;5-Bromo-2-methoxynicotinicAci;2-Methoxy-5-bromoinicotinic acid;5-BROMO-2-METHOXY-NICOTINIC ACID;5-Bromo-2-methoxynicotinic acid 98%;5-Bromo-2-methoxypyridine-3-carboxylic acid;5-BROMO-2-METHOXY-3-PYRIDINECARBOXYLIC ACID;3-Pyridinecarboxylic acid, 5-bromo-2-methoxy-;5-BROMO-2-METHOXY-NICOTINIC ACID ISO 9001：2015 REACH
- CBNumber
- CB2313227
- Molecular Formula
- C7H6BrNO3
- Formula Weight
- 232.03
- MOL File
- 54916-66-4.mol
5-BROMO-2-METHOXY-NICOTINIC ACID Property
- Melting point:
- 156-158
- Boiling point:
- 324.8±42.0 °C(Predicted)
- Density
- 1.713
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 2.97±0.10(Predicted)
- form
- solid
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H6BrNO3/c1-12-6-5(7(10)11)2-4(8)3-9-6/h2-3H,1H3,(H,10,11)
- InChIKey
- SJLXURQPRRMPIV-UHFFFAOYSA-N
- SMILES
- C1(OC)=NC=C(Br)C=C1C(O)=O
- CAS DataBase Reference
- 54916-66-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 725250
- Product name
- 5-Bromo-2-methoxypyridine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $103
- Updated
- 2023/06/20
- Product number
- B696755
- Product name
- 5-Bromo-2-methoxynicotinicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B696755
- Product name
- 5-Bromo-2-methoxynicotinicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B696755
- Product name
- 5-Bromo-2-methoxynicotinicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 023784
- Product name
- 5-Bromo-2-methoxy-nicotinic acid
- Purity
- 99%
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
5-BROMO-2-METHOXY-NICOTINIC ACID Chemical Properties,Usage,Production
Uses
5-Bromo-2-methoxy-nicotinic acid is used as an intermediate in pharmaceutical synthesis and can be employed to prepare RXFP1 receptor agonists. Its synthetic products can selectively activate the RXFP1 receptor for the treatment of heart failure, with an EC50 value of approximately 6.3nM.
Synthesis
16498-81-0
54916-66-4
General procedure for the synthesis of 5-bromo-2-methoxynicotinic acid from 2-methoxynicotinic acid: 2-methoxynicotinic acid (20 g, 130.60 mmol) was dissolved in H2O (1500 mL) at room temperature, followed by slow addition of Br2 (20 mL, 375.45 mmol). The reaction mixture was stirred continuously at room temperature overnight. Upon completion of the reaction, the solid product was collected by filtration and washed thoroughly with deionized water and finally dried to afford 5-bromo-2-methoxynicotinic acid (25 g, 82% yield). The structure of the product was confirmed by 1H-NMR (DMSO-d6, 400 MHz) and mass spectrometry (MS): 1H-NMR δ 13.33 (br s, 1H), 8.47 (d, J = 2.4 Hz, 1H), 8.21 (d, J = 2.4 Hz, 1H), 3.90 (s, 3H); MS (M + H)+ m/z: 232/234.
References
[1] Patent: WO2013/33971, 2013, A1. Location in patent: Page/Page column 144
[2] Patent: US2014/213571, 2014, A1. Location in patent: Paragraph 0572
5-BROMO-2-METHOXY-NICOTINIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
5-BROMO-2-METHOXY-NICOTINIC ACID Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75
View Lastest Price from 5-BROMO-2-METHOXY-NICOTINIC ACID manufacturers
- Product
- 5-Bromo-2-methoxynicotinic acid 54916-66-4
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-08-06
- Product
- 5-BROMO-2-METHOXY-NICOTINIC ACID 54916-66-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25
- Product
- 5-BROMO-2-METHOXY-NICOTINIC ACID 54916-66-4
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-31