(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide

Product Name: (R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide
CAS No.: 1492952-76-7
Chemical Name: (R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide
Synonyms: Asciminib;ABL-001;EOS-61420;L1F3R18W77;ABL001;ABL-001;UNII-L1F3R18W77;asciminib free base;ABL-001 (ASCIMINIB);Asciminib (ABL-001);ABL-001; AB -001; ABL001; ASCIMINIB; ASCIMINIB FREE BASE;
CBNumber: CB23133462
Molecular Formula: C20H18ClF2N5O3
Formula Weight: 449.84
MOL File: 1492952-76-7.mol

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(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide Property

Boiling point:: 631.7±55.0 °C(Predicted)
Density: 1.518±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:93.0(Max Conc. mg/mL);206.74(Max Conc. mM)
Ethanol:90.0(Max Conc. mg/mL);200.07(Max Conc. mM)
form: A crystalline solid
pka: 10.81±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26126
Product name: Asciminib
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 26126
Product name: Asciminib
Packaging: 10mg
Price: $477
Updated: 2024/03/01

Cayman Chemical

Product number: 26126
Product name: Asciminib
Packaging: 5mg
Price: $254
Updated: 2024/03/01

AK Scientific

Product number: 0090DW
Product name: Asciminib
Packaging: 5mg
Price: $380
Updated: 2021/12/16

ChemScene

Product number: CS-7655
Product name: Asciminib
Purity: 99.78%
Packaging: 5mg
Price: $155
Updated: 2021/12/16

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(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide Chemical Properties,Usage,Production

Description

Asciminib is the first-in-class Specifically Targeting the ABL1 Myristoyl Pocket (STAMP) inhibitor, which was granted accelerated approval in 2021 for patients with Philadelphia chromosomepositive (Ph+) chronic myeloid leukemia (CML) in chronic phase, previously treated with two or more tyrosine kinase inhibitors (TKIs), and for adult patients with Ph+ CML in chronic phase with the T315I mutation. Asciminib binds to a myristoyl site of the BCR-ABL1 protein and locks the protein into an inactive conformation through a mechanism distinct from those of all other orthosteric TKIs such as imatinib, thus overcoming drug resistance arising from ATPbinding site mutations. Asciminib mimics the function of the myristoylated N-terminus of ABL1 and restores the natural autoinhibition of the ABL1b protein.

Uses

Asciminib comprises ABL kinase inhibitors and/or SLC7A11 inhibitors for the treatment of cancer and central nervous system (CNS) disorders.

General Description

Class: non-receptor tyrosine kinase
Treatment: CML
Elimination half-life = 14.2 h
Protein binding = 97%

target

BCR-ABL1

(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide Suppliers

China 107 India 1 United States 7 USA 1 Global 116

MedChemexpress LLC

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Cayman Chemical Company

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1492952-76-7, (R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamideRelated Search:

CCT 244747 6-amino-1,3-dimethyl-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 1-[2-CHLORO-6-[[(3-IODOPHENYL)METHYL]AMINO]-9H-PURIN-9-YL]-1-DEOXY-N-METHYL-BETA-D-RIBOFURANURONAMIDE Naquotinib (mesylate) HS-173 BI-9564 BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- 4-Propylphenol

ABL001;ABL-001

ABL-001; AB -001; ABL001; ASCIMINIB; ASCIMINIB FREE BASE;

asciminib free base

(R)-N- (4-(CHLORODIFLUOROMETHOXY)PHENYL)- 6-(3- HYDROXYPYRROLIDIN-1- YL)-5- (1H-PYRAZOL- 5-YL)NICOTI

(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide

ABL-001

Asciminib

EOS-61420

L1F3R18W77

UNII-L1F3R18W77

3-Pyridinecarboxamide, N-[4-(chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxy-1-pyrrolidinyl]-5-(1H-pyrazol-3-yl)-

Asciminib (ABL-001)

ABL-001 (ASCIMINIB)

(R)-N-(4-(Chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-3-yl)nicotinamide

1492952-76-7

C20H18ClF2N5O3