ChemicalBook > CAS DataBase List > Adavivint

Adavivint

Product Name
Adavivint
CAS No.
1467093-03-3
Chemical Name
Adavivint
Synonyms
SM04690;CPD1633;Adavivint;Lorecivivint;SM-04690;SM 04690;SM04690;Wnt,SM 04690,Adavivint,SM04690,Lorecivivint,SM-04690,inhibit,Inhibitor;N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide;Butanamide, N-[5-[3-[7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl]-3-pyridinyl]-3-methyl-
CBNumber
CB23137556
Molecular Formula
C29H24FN7O
Formula Weight
505.55
MOL File
1467093-03-3.mol
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Adavivint Property

Density 
1.365±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO:27.5(Max Conc. mg/mL);54.4(Max Conc. mM)
pka
7.75±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0031495
Product name
Adavivint
Purity
99.12%
Packaging
5mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-0031495
Product name
Adavivint
Purity
99.12%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0031495
Product name
Adavivint
Purity
99.12%
Packaging
25mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0031495
Product name
Adavivint
Purity
99.12%
Packaging
100mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-0031495
Product name
Adavivint
Purity
99.12%
Packaging
50mg
Price
$450
Updated
2021/12/16
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Adavivint Chemical Properties,Usage,Production

Uses

Adavivint is an intra-articular potential disease-modifying osteoarthritis drug.

Biological Activity

Adavivint (SM04690) is a potent canonical Wnt signaling pathway inhibitor with EC50 of 19.5 nM for TCF/LEF reporter gene. It was more potent than other known Wnt inhibitors in multiple cellular experiments.

in vitro

Treatment of bone marrow-derived human mesenchymal stem cells (CD29+, CD44+ CD166+ CD105+ CD45-) with SM04690 induced a concentration-dependent decrease in Wnt pathway gene expression (ASCL1, LEF1, TCF7L2, TCF7 , C-262 MYC and AXIN2). Selective activation of Wnt signaling pathway with Wnt3a or GSK3β inhibitor CHIR-99021, in IEC6 (intestinal stem cells sensitive to Wnt activation), M04690 can inhibit the expression of AXIN2 and LGR5; in hMSCs, inhibit the expression of AXIN2, TCF7 and LEF1 Express. It has minimal effects on non-canonical Wnt signaling and BMP signaling. In vitro, SM04690 protects chondrocytes from metabolic breakdown.

in vivo

Intra-articular injection of Adavivint promotes cartilage growth and improves joint health in a rat model of knee osteoarthritis. In vivo, it reduces cartilage breakdown.

target

Adavivint Preparation Products And Raw materials

Raw materials

Preparation Products

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1467093-03-3, AdavivintRelated Search:

Barium carbonate 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide BAY 299 T-26c AZD-7594 4-[4-(1-methyl-1H-pyrazol-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]-benzonitrile ABBV-744 Zofluza intermediate RGX-104 HCl

  • N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide
  • CPD1633
  • SM04690
  • SM-04690;SM 04690;SM04690
  • Butanamide, N-[5-[3-[7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl]-3-pyridinyl]-3-methyl-
  • Adavivint
  • Wnt,SM 04690,Adavivint,SM04690,Lorecivivint,SM-04690,inhibit,Inhibitor
  • Lorecivivint
  • 1467093-03-3
  • C29H24FN7O
    • TargetValue
    Wnt
    ()