ChemicalBook > CAS DataBase List > ABBV-744
ABBV-744
- Product Name
- ABBV-744
- CAS No.
- 2138861-99-9
- Chemical Name
- ABBV-744
- Synonyms
- CS-2875;CPD1639;ABBV-744;ABBV-744 (ABBV744);ABBV-744; ABBV 744; ABBV744;2138861-99-9;N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-h ydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-1H,6H, 7H-pyrrolo[2,3-c]pyridine-2-carboxamide;N-Ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide;1H-Pyrrolo[2,3-c]pyridine-2-carboxamide, N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-;ABBV 744,Inhibitor,Antitumor,Selective,Oral,inhibit,Potent,Epigenetic Reader Domain,Drug-like,Human immunodeficiency virus,LNCaP,CYP3A4,ABBV-744,HIV
- CBNumber
- CB53381028
- Molecular Formula
- C28H30FN3O4
- Formula Weight
- 491.55
- MOL File
- 2138861-99-9.mol
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ABBV-744 Property
- Boiling point:
- 663.7±55.0 °C(Predicted)
- Density
- 1.262±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:33.57(Max Conc. mg/mL);68.29(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.51(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);61.03(Max Conc. mM) - form
- A crystalline solid
- pka
- 13.77±0.40(Predicted)
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0043318
- Product name
- ABBV-744
- Purity
- 99.48%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0043318
- Product name
- ABBV-744
- Purity
- 99.48%
- Packaging
- 10mg
- Price
- $190
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0043318
- Product name
- ABBV-744
- Purity
- 99.48%
- Packaging
- 25mg
- Price
- $390
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0043318
- Product name
- ABBV-744
- Purity
- 99.48%
- Packaging
- 50mg
- Price
- $550
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC11452
- Product name
- ABBV-744
- Purity
- >98%
- Packaging
- 100mg
- Price
- $600
- Updated
- 2021/12/16
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ABBV-744 Chemical Properties,Usage,Production
Uses
ABBV 744 is a bromodomain and extra-??terminal (BET) inhibitor used as a combination therapy for cancer treatment.
Biological Activity
ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It can be further studied for the treatment of acute myeloid leukemia and cancer.
in vitro
ABBV-744 is a potent BDII inhibitor that inhibits BRD2/3/4. The binding preference for BDII is more than 250 times that for BDI, with favorable drug-like properties. It is also an inhibitor of the androgen receptor transduction pathway.
in vivo
The maximum tolerated dose of ABBV-744 induces tumor growth inhibition in AML and prostate cancer xenograft models.
target
| Target | Value |
| BDII () |