ChemicalBook > CAS DataBase List > ABBV-744

ABBV-744

Product Name
ABBV-744
CAS No.
2138861-99-9
Chemical Name
ABBV-744
Synonyms
CS-2875;CPD1639;ABBV-744;ABBV-744 (ABBV744);ABBV-744, 10 mM in DMSO;ABBV-744; ABBV 744; ABBV744;2138861-99-9;N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-h ydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-1H,6H, 7H-pyrrolo[2,3-c]pyridine-2-carboxamide;N-Ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide;1H-Pyrrolo[2,3-c]pyridine-2-carboxamide, N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-;ABBV 744,Inhibitor,Antitumor,Selective,Oral,inhibit,Potent,Epigenetic Reader Domain,Drug-like,Human immunodeficiency virus,LNCaP,CYP3A4,ABBV-744,HIV
CBNumber
CB53381028
Molecular Formula
C28H30FN3O4
Formula Weight
491.55
MOL File
2138861-99-9.mol
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ABBV-744 Property

Boiling point:
663.7±55.0 °C(Predicted)
Density 
1.262±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:33.57(Max Conc. mg/mL);68.29(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.51(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);61.03(Max Conc. mM)
form 
A crystalline solid
pka
13.77±0.40(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

ChemScene
Product number
CS-0043318
Product name
ABBV-744
Purity
99.48%
Packaging
5mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-0043318
Product name
ABBV-744
Purity
99.48%
Packaging
10mg
Price
$190
Updated
2021/12/16
ChemScene
Product number
CS-0043318
Product name
ABBV-744
Purity
99.48%
Packaging
25mg
Price
$390
Updated
2021/12/16
ChemScene
Product number
CS-0043318
Product name
ABBV-744
Purity
99.48%
Packaging
50mg
Price
$550
Updated
2021/12/16
DC Chemicals
Product number
DC11452
Product name
ABBV-744
Purity
>98%
Packaging
100mg
Price
$600
Updated
2021/12/16
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ABBV-744 Chemical Properties,Usage,Production

Uses

ABBV 744 is a bromodomain and extra-??terminal (BET) inhibitor used as a combination therapy for cancer treatment.

Biological Activity

ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It can be further studied for the treatment of acute myeloid leukemia and cancer.

in vitro

ABBV-744 is a potent BDII inhibitor that inhibits BRD2/3/4. The binding preference for BDII is more than 250 times that for BDI, with favorable drug-like properties. It is also an inhibitor of the androgen receptor transduction pathway.

in vivo

The maximum tolerated dose of ABBV-744 induces tumor growth inhibition in AML and prostate cancer xenograft models.

target

ABBV-744 Preparation Products And Raw materials

Raw materials

Preparation Products

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ABBV-744 Suppliers

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2138861-99-9, ABBV-744Related Search:

BAY 299 T-26c AZD-7594 4-[4-(1-methyl-1H-pyrazol-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]-benzonitrile Zofluza intermediate RGX-104 HCl Adavivint

  • ABBV-744
  • CPD1639
  • CS-2875
  • ABBV-744; ABBV 744; ABBV744;2138861-99-9
  • N-Ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide
  • 1H-Pyrrolo[2,3-c]pyridine-2-carboxamide, N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-
  • N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-h ydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-1H,6H, 7H-pyrrolo[2,3-c]pyridine-2-carboxamide
  • ABBV 744,Inhibitor,Antitumor,Selective,Oral,inhibit,Potent,Epigenetic Reader Domain,Drug-like,Human immunodeficiency virus,LNCaP,CYP3A4,ABBV-744,HIV
  • ABBV-744 (ABBV744)
  • ABBV-744, 10 mM in DMSO
  • 2138861-99-9
    • TargetValue
    BDII
    ()