Adavivint
- Product Name
- Adavivint
- CAS No.
- 1467093-03-3
- Chemical Name
- Adavivint
- Synonyms
- SM04690;CPD1633;Adavivint;Lorecivivint;Adavivint, 10 mM in DMSO;SM-04690;SM 04690;SM04690;Adavivint (SM04690) ，S8761;Adavivint，SM 04690，LORECIVIVINT;Wnt,SM 04690,Adavivint,SM04690,Lorecivivint,SM-04690,inhibit,Inhibitor;N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide
- CBNumber
- CB23137556
- Molecular Formula
- C29H24FN7O
- Formula Weight
- 505.55
- MOL File
- 1467093-03-3.mol
Adavivint Property
- Density
- 1.365±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:27.5(Max Conc. mg/mL);54.4(Max Conc. mM)
- pka
- 7.75±0.40(Predicted)
- form
- Solid
- color
- Light yellow to gray
- InChIKey
- AQDWDWAYVBQMAM-UHFFFAOYSA-N
- SMILES
- C(NC1=CC(C2C=CC3=C(C=2)C(C2=NC4C(C5=CC=CC(F)=C5)=CN=CC=4N2)=NN3)=CN=C1)(=O)CC(C)C
N-Bromosuccinimide Price
- Product number
- 43927
- Product name
- Adavivint
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $28
- Updated
- 2026/04/30
- Product number
- 43927
- Product name
- Adavivint
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2026/04/30
- Product number
- 43927
- Product name
- Adavivint
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $152
- Updated
- 2026/04/30
- Product number
- 43927
- Product name
- Adavivint
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $241
- Updated
- 2026/04/30
- Product number
- CS-0031495
- Product name
- Adavivint
- Purity
- 99.12%
- Packaging
- 25mg
- Price
- $250
- Updated
- 2021/12/16
Adavivint Chemical Properties,Usage,Production
Uses
Adavivint is an intra-articular potential disease-modifying osteoarthritis drug.
Biological Activity
Adavivint (SM04690) is a potent canonical Wnt signaling pathway inhibitor with EC50 of 19.5 nM for TCF/LEF reporter gene. It was more potent than other known Wnt inhibitors in multiple cellular experiments.
in vitro
Treatment of bone marrow-derived human mesenchymal stem cells (CD29+, CD44+ CD166+ CD105+ CD45-) with SM04690 induced a concentration-dependent decrease in Wnt pathway gene expression (ASCL1, LEF1, TCF7L2, TCF7 , C-262 MYC and AXIN2). Selective activation of Wnt signaling pathway with Wnt3a or GSK3β inhibitor CHIR-99021, in IEC6 (intestinal stem cells sensitive to Wnt activation), M04690 can inhibit the expression of AXIN2 and LGR5; in hMSCs, inhibit the expression of AXIN2, TCF7 and LEF1 Express. It has minimal effects on non-canonical Wnt signaling and BMP signaling. In vitro, SM04690 protects chondrocytes from metabolic breakdown.
in vivo
Intra-articular injection of Adavivint promotes cartilage growth and improves joint health in a rat model of knee osteoarthritis. In vivo, it reduces cartilage breakdown.
target
| Target | Value |
| Wnt () |