ANTISAUVAGINE-30

ChemicalBook > CAS DataBase List > ANTISAUVAGINE-30

Product Name: ANTISAUVAGINE-30
CAS No.: 220673-95-0
Chemical Name: ANTISAUVAGINE-30
Synonyms: ANTISAUVAGINE-30;PubChem ID: 90471086;M.W. 3650.29 C161H274N48O46S;(D-Phe??,His??)-Sauvagine (11-40);(D-PHE11,HIS12)-SAUVAGINE (11-40);11-D-Phenylalanine-12-L-histidine-11-40-sauvagin;(D-PHE11,HIS12)-SAUVAGINE (11-40) TRIFLUOROACETATE SALT;D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2;H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THE-ILE-OH;H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2
CBNumber: CB2314057
Molecular Formula: C161H273N47O47S
Formula Weight: 3651.24
MOL File: 220673-95-0.mol

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ANTISAUVAGINE-30 Property

RTECS: VQ6120000
storage temp.: −20°C
form: Powder
Water Solubility: Soluble to 1 mg/ml in water

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J66055
Product name: Antisauvagine-30
Packaging: 1mg
Price: $910
Updated: 2021/12/16

Tocris

Product number: 2071
Product name: Antisauvagine-30
Packaging: 1
Price: $465
Updated: 2021/12/16

ApexBio Technology

Product number: B5253
Product name: Antisauvagine-30
Packaging: 1mg
Price: $675
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0004449
Product name: ANTISAUVAGINE-30
Purity: 95.00%
Packaging: 100MG
Price: $739.2
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0004449
Product name: ANTISAUVAGINE-30
Purity: 95.00%
Packaging: 1G
Price: $1871.1
Updated: 2021/12/16

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ANTISAUVAGINE-30 Chemical Properties,Usage,Production

Enzyme inhibitor

This highly selective CRF2 antagonist (MW = 3650.29 g/mol; CAS 220673-95-0; Sequence: D-Phe-His-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile- Glu-Lys-Gln-Glu-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2; Solubility: 5 mg/mL H2O; Alternate Name: [D-Phe 11 ,His 12 ]-Sauvagine (11- 40)) targets human Corticotropin-Releasing hormone (CRH) Receptor-2 subtypes CRF2β (Ki = 1.4 nM), with a much higher value of 154 nM for CRF1. (See also Astressin; K41448) Type-2 GPCRs reside in plasma membranes of hormone-sensitive cells and bind CRH, a peptide hormone and neurotransmitter involved in stress responses. Antisauvagine-30 blocks (pA2 = 8.49) sauvagine-stimulated accumulation of cAMP in HEK-mCRF2β cells. It also prevents stress-enhanced fear conditioning and MEK1/2- dependent activation of ERK1/2 in mice and suggesting a role for protein kinase signaling in the hippocampus and its modulation by CRF2 as a possible link between stress and fear memory.

ANTISAUVAGINE-30 Preparation Products And Raw materials

Raw materials

Preparation Products

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ANTISAUVAGINE-30 Suppliers

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220673-95-0, ANTISAUVAGINE-30Related Search:

2'-Deoxyadenosine SAUVAGINE ANTISAUVAGINE-30 TRIFLUOROACETATE SALT H-THR-VAL-OH ANTISAUVAGINE-30

D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2

(D-PHE11,HIS12)-SAUVAGINE (11-40)

(D-PHE11,HIS12)-SAUVAGINE (11-40) TRIFLUOROACETATE SALT

H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THE-ILE-OH

H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2

ANTISAUVAGINE-30

M.W. 3650.29 C161H274N48O46S

11-D-Phenylalanine-12-L-histidine-11-40-sauvagin

PubChem ID: 90471086

(D-Phe??,His??)-Sauvagine (11-40)

220673-95-0

C161H273N47O47S

CRF receptor and related