ANTISAUVAGINE-30
- Product Name
- ANTISAUVAGINE-30
- CAS No.
- 220673-95-0
- Chemical Name
- ANTISAUVAGINE-30
- Synonyms
- ANTISAUVAGINE-30;PubChem ID: 90471086;M.W. 3650.29 C161H274N48O46S;(D-Phe??,His??)-Sauvagine (11-40);(D-PHE11,HIS12)-SAUVAGINE (11-40);11-D-Phenylalanine-12-L-histidine-11-40-sauvagin;(D-PHE11,HIS12)-SAUVAGINE (11-40) TRIFLUOROACETATE SALT;D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2;H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THE-ILE-OH;H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2
- CBNumber
- CB2314057
- Molecular Formula
- C161H273N47O47S
- Formula Weight
- 3651.24
- MOL File
- 220673-95-0.mol
ANTISAUVAGINE-30 Property
- RTECS
- VQ6120000
- storage temp.
- −20°C
- form
- Powder
- Water Solubility
- Soluble to 1 mg/ml in water
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- J66055
- Product name
- Antisauvagine-30
- Packaging
- 1mg
- Price
- $910
- Updated
- 2021/12/16
- Product number
- 2071
- Product name
- Antisauvagine-30
- Packaging
- 1
- Price
- $465
- Updated
- 2021/12/16
- Product number
- B5253
- Product name
- Antisauvagine-30
- Packaging
- 1mg
- Price
- $675
- Updated
- 2021/12/16
- Product number
- PEP0004449
- Product name
- ANTISAUVAGINE-30
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $739.2
- Updated
- 2021/12/16
- Product number
- PEP0004449
- Product name
- ANTISAUVAGINE-30
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1871.1
- Updated
- 2021/12/16
ANTISAUVAGINE-30 Chemical Properties,Usage,Production
Enzyme inhibitor
This highly selective CRF2 antagonist (MW = 3650.29 g/mol; CAS 220673-95-0; Sequence: D-Phe-His-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile- Glu-Lys-Gln-Glu-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2; Solubility: 5 mg/mL H2O; Alternate Name: [D-Phe 11 ,His 12 ]-Sauvagine (11- 40)) targets human Corticotropin-Releasing hormone (CRH) Receptor-2 subtypes CRF2β (Ki = 1.4 nM), with a much higher value of 154 nM for CRF1. (See also Astressin; K41448) Type-2 GPCRs reside in plasma membranes of hormone-sensitive cells and bind CRH, a peptide hormone and neurotransmitter involved in stress responses. Antisauvagine-30 blocks (pA2 = 8.49) sauvagine-stimulated accumulation of cAMP in HEK-mCRF2β cells. It also prevents stress-enhanced fear conditioning and MEK1/2- dependent activation of ERK1/2 in mice and suggesting a role for protein kinase signaling in the hippocampus and its modulation by CRF2 as a possible link between stress and fear memory.