METHYL 2-CHLORO-5-IODONICOTINATE

Product Name: METHYL 2-CHLORO-5-IODONICOTINATE
CAS No.: 78686-83-6
Chemical Name: METHYL 2-CHLORO-5-IODONICOTINATE
Synonyms: METHYL 2-CHLORO-5-IODONICOTINATE;2-Chloro-5-iodoicotinic acid methyl ester;2-Chloro-5-iodo-nicotinic acid methyl ester;Methyl 2-chloro-5-iodopyridine-3-carboxylate;Methyl 2-chloro-5-iodo-3-pyridinecarboxylate;3-Pyridinecarboxylic acid, 2-chloro-5-iodo-, methyl ester
CBNumber: CB2314628
Molecular Formula: C7H5ClINO2
Formula Weight: 297.48
MOL File: 78686-83-6.mol

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METHYL 2-CHLORO-5-IODONICOTINATE Property

Melting point:: 70-73°
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: White

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M295605
Product name: Methyl2-chloro-5-iodonicotinate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 454902
Product name: Methyl 2-chloro-5-iodonicotinate
Packaging: 100mg
Price: $312
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: Y14746
Product name: Methyl2-chloro-5-iodonicotinate
Purity: 98%
Packaging: 5g
Price: $190
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: Y14746
Product name: Methyl2-chloro-5-iodonicotinate
Purity: 98%
Packaging: 1g
Price: $50
Updated: 2021/12/16

Matrix Scientific

Product number: 046002
Product name: Methyl 2-chloro-5-iodonicotinate
Purity: >95%
Packaging: 500mg
Price: $77
Updated: 2021/12/16

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METHYL 2-CHLORO-5-IODONICOTINATE Chemical Properties,Usage,Production

Synthesis

116387-40-7

78686-83-6

Step 2 of Scheme 13: Methyl 5-iodo-2-hydroxynicotinate (4.75 g, 17.1 mmol) was dissolved in trichlorophosphorus (50 mL) and heated to reflux for 24 hours. After completion of the reaction, the solvent was removed by rotary evaporator. The crude product was neutralized with saturated sodium bicarbonate solution and subsequently extracted with ether. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated by rotary evaporator. The crude product was purified by silica gel column chromatography to afford 4.3 g (85% yield) of methyl 2-chloro-5-iodonicotinate using a hexane solution of 5% ethyl acetate as eluent. The physical and chemical properties of this compound have been documented in Journal of Organic Chemistry, 1989, vol. 54.

References

[1] Patent: US2005/203081, 2005, A1. Location in patent: Page/Page column 13; 33
[2] Journal of Medicinal Chemistry, 1993, vol. 36, # 18, p. 2676 - 2688
[3] Patent: US5250548, 1993, A
[4] Patent: WO2008/76425, 2008, A1. Location in patent: Page/Page column 54
[5] Patent: WO2008/130600, 2008, A2. Location in patent: Page/Page column 46

METHYL 2-CHLORO-5-IODONICOTINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 2-CHLORO-5-IODONICOTINATE Suppliers

China 67 India 1 United Kingdom 1 United States 10 Global 79

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View Lastest Price from METHYL 2-CHLORO-5-IODONICOTINATE manufacturers

Career Henan Chemica Co

Product: METHYL 2-CHLORO-5-IODONICOTINATE 78686-83-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: MIn98%HPLC/LC
Supply Ability: 100KGS
Release date: 2020-10-29

78686-83-6, METHYL 2-CHLORO-5-IODONICOTINATERelated Search:

Closantel Iodine monochloride 2, 4-DICHLORO-5-IODOPYRIMIDINE 4-CHLORO-2-FLUOROIODOBENZENE (5-IODO-PYRIDIN-3-YL)-METHANOL 2-CHLORO-5-IODONICOTINIC ACID 5-IODO-PYRIDINE-3-CARBALDEHYDE METHYL 2-CHLORO-5-IODONICOTINATE 2-Chloro-5-iodopyridine 2-CHLORO-5-IODO-3-METHYLPYRIDINE 5-IODONICOTINIC ACID

METHYL 2-CHLORO-5-IODONICOTINATE

Methyl 2-chloro-5-iodopyridine-3-carboxylate

2-Chloro-5-iodo-nicotinic acid methyl ester

2-Chloro-5-iodoicotinic acid methyl ester

3-Pyridinecarboxylic acid, 2-chloro-5-iodo-, methyl ester

Methyl 2-chloro-5-iodo-3-pyridinecarboxylate

78686-83-6