METHYL 2-CHLORO-5-IODONICOTINATE
- Product Name
- METHYL 2-CHLORO-5-IODONICOTINATE
- CAS No.
- 78686-83-6
- Chemical Name
- METHYL 2-CHLORO-5-IODONICOTINATE
- Synonyms
- METHYL 2-CHLORO-5-IODONICOTINATE;2-Chloro-5-iodoicotinic acid methyl ester;2-Chloro-5-iodo-nicotinic acid methyl ester;Methyl 2-chloro-5-iodopyridine-3-carboxylate;Methyl 2-chloro-5-iodo-3-pyridinecarboxylate;3-Pyridinecarboxylic acid, 2-chloro-5-iodo-, methyl ester
- CBNumber
- CB2314628
- Molecular Formula
- C7H5ClINO2
- Formula Weight
- 297.48
- MOL File
- 78686-83-6.mol
METHYL 2-CHLORO-5-IODONICOTINATE Property
- Melting point:
- 70-73°
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- M295605
- Product name
- Methyl2-chloro-5-iodonicotinate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 454902
- Product name
- Methyl 2-chloro-5-iodonicotinate
- Packaging
- 100mg
- Price
- $312
- Updated
- 2021/12/16
- Product number
- Y14746
- Product name
- Methyl2-chloro-5-iodonicotinate
- Purity
- 98%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 046002
- Product name
- Methyl 2-chloro-5-iodonicotinate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $77
- Updated
- 2021/12/16
- Product number
- 2322AC
- Product name
- Methyl2-chloro-5-iodonicotinate
- Packaging
- 100mg
- Price
- $84
- Updated
- 2021/12/16
METHYL 2-CHLORO-5-IODONICOTINATE Chemical Properties,Usage,Production
Synthesis
116387-40-7
78686-83-6
Step 2 of Scheme 13: Methyl 5-iodo-2-hydroxynicotinate (4.75 g, 17.1 mmol) was dissolved in trichlorophosphorus (50 mL) and heated to reflux for 24 hours. After completion of the reaction, the solvent was removed by rotary evaporator. The crude product was neutralized with saturated sodium bicarbonate solution and subsequently extracted with ether. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated by rotary evaporator. The crude product was purified by silica gel column chromatography to afford 4.3 g (85% yield) of methyl 2-chloro-5-iodonicotinate using a hexane solution of 5% ethyl acetate as eluent. The physical and chemical properties of this compound have been documented in Journal of Organic Chemistry, 1989, vol. 54.
References
[1] Patent: US2005/203081, 2005, A1. Location in patent: Page/Page column 13; 33
[2] Journal of Medicinal Chemistry, 1993, vol. 36, # 18, p. 2676 - 2688
[3] Patent: US5250548, 1993, A
[4] Patent: WO2008/76425, 2008, A1. Location in patent: Page/Page column 54
[5] Patent: WO2008/130600, 2008, A2. Location in patent: Page/Page column 46
METHYL 2-CHLORO-5-IODONICOTINATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL 2-CHLORO-5-IODONICOTINATE Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from METHYL 2-CHLORO-5-IODONICOTINATE manufacturers
- Product
- METHYL 2-CHLORO-5-IODONICOTINATE 78686-83-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- MIn98%HPLC/LC
- Supply Ability
- 100KGS
- Release date
- 2020-10-29