Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

Product Name: Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
CAS No.: 2003260-55-5
Chemical Name: Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
Synonyms: CS-2874;KDM4B-IN-B3;NCGC00244536;KDM4B Inhibitor B3;NCGC00244536(Benzamide);KDM4B INHIBITOR COMPOUND B3;3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide;Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-;NCGC 00244536,inhibit,Histone Demethylase,NCGC00244536,Inhibitor,NCGC-00244536
CBNumber: CB23146688
Molecular Formula: C25H22N2O2
Formula Weight: 382.45
MOL File: 2003260-55-5.mol

More

Less

Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Property

Boiling point:: 646.9±55.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF:30.0(Max Conc. mg/mL);78.44(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.86(Max Conc. mM)
DMSO:44.22(Max Conc. mg/mL);115.63(Max Conc. mM)
Ethanol:1.5(Max Conc. mg/mL);3.92(Max Conc. mM)
form: A crystalline solid
pka: 4.81±0.40(Predicted)
color: Light yellow to green yellow

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 18478
Product name: NCGC00244536
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 18478
Product name: NCGC00244536
Packaging: 25mg
Price: $593
Updated: 2024/03/01

Cayman Chemical

Product number: 18478
Product name: NCGC00244536
Packaging: 5mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 18478
Product name: NCGC00244536
Packaging: 10mg
Price: $263
Updated: 2024/03/01

ChemScene

Product number: CS-6877
Product name: NCGC00244536
Purity: 98.02%
Packaging: 5mg
Price: $396
Updated: 2021/12/16

More

Less

Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Chemical Properties,Usage,Production

Biological Activity

NCGC00244536 is a potent KDM4B inhibitor with IC50 of 10 nM.

in vitro

NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC ₅₀ =40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4 . NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC ₅₀ s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC ₅₀ s.

in vivo

Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis .

Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Suppliers

China 52 India 1 United States 8 Global 61

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7887
Advantage: 56

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4566
Advantage: 55

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-0431-80514535 19917294565
Email: et@chemextension.com
Country: China
ProdList: 3980
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8012
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2990
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7296
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 9996
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1925
Advantage: 55

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

2003260-55-5, Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-Related Search:

KDM4B INHIBITOR COMPOUND B3

CS-2874

Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

NCGC00244536

KDM4B-IN-B3

KDM4B Inhibitor B3

NCGC 00244536,inhibit,Histone Demethylase,NCGC00244536,Inhibitor,NCGC-00244536

3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide

NCGC00244536(Benzamide)

2003260-55-5