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Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

Product Name
Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
CAS No.
2003260-55-5
Chemical Name
Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
Synonyms
CS-2874;KDM4B-IN-B3;NCGC00244536;KDM4B Inhibitor B3;NCGC00244536(Benzamide);KDM4B INHIBITOR COMPOUND B3;3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide;Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-;NCGC 00244536,inhibit,Histone Demethylase,NCGC00244536,Inhibitor,NCGC-00244536
CBNumber
CB23146688
Molecular Formula
C25H22N2O2
Formula Weight
382.45
MOL File
2003260-55-5.mol
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Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Property

Boiling point:
646.9±55.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF:30.0(Max Conc. mg/mL);78.44(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.86(Max Conc. mM)
DMSO:44.22(Max Conc. mg/mL);115.63(Max Conc. mM)
Ethanol:1.5(Max Conc. mg/mL);3.92(Max Conc. mM)
form 
A crystalline solid
pka
4.81±0.40(Predicted)
color 
Light yellow to green yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18478
Product name
NCGC00244536
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
18478
Product name
NCGC00244536
Packaging
25mg
Price
$593
Updated
2024/03/01
Cayman Chemical
Product number
18478
Product name
NCGC00244536
Packaging
5mg
Price
$143
Updated
2024/03/01
Cayman Chemical
Product number
18478
Product name
NCGC00244536
Packaging
10mg
Price
$263
Updated
2024/03/01
ChemScene
Product number
CS-6877
Product name
NCGC00244536
Purity
98.02%
Packaging
5mg
Price
$396
Updated
2021/12/16
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Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Chemical Properties,Usage,Production

Biological Activity

NCGC00244536 is a potent KDM4B inhibitor with IC50 of 10 nM.

in vitro

NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC 50 =40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4 . NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC 50 s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC 50 s.

in vivo

Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis .

Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Suppliers

China 52 India 1 United States 8 Global 61
InvivoChem
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+1-708-310-1919 +1-13798911105
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708-557-7486
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sales@invivochem.cn
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United States
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Cckinase, Inc.
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+1 (732)236-3202
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sales@cckinase.com
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United States
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BOC Sciences
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+1-631-485-4226
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1-631-614-7828
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inquiry@bocsci.com
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United States
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TargetMol Chemicals Inc.
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support@targetmol.com
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United States
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Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
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United States
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BOC Sciences
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16314854226
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info@bocsci.com
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United States
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Cayman Chemical Company
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cayman@caymanchem.com
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United States
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MedChemExpress
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sales@medchemexpress.com
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United States
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2003260-55-5, Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-Related Search:


  • KDM4B INHIBITOR COMPOUND B3
  • CS-2874
  • Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
  • NCGC00244536
  • KDM4B-IN-B3
  • KDM4B Inhibitor B3
  • NCGC 00244536,inhibit,Histone Demethylase,NCGC00244536,Inhibitor,NCGC-00244536
  • 3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide
  • NCGC00244536(Benzamide)
  • 2003260-55-5