6-Bromoquinoline
Bromoquinoline Application and synthetic method- Product Name
- 6-Bromoquinoline
- CAS No.
- 5332-25-2
- Chemical Name
- 6-Bromoquinoline
- Synonyms
- 6-Bromoquinoline,97%;NSC 3996;6-BromoquinoL;6-Br-quinoline;6-bromo-quinolin;6-BROMOQUINOLINE;6-BROMOOQUINOLINE;TIMTEC-BB SBB001559;Quinoline, 6-bromo-;6-Bromoquinoline>
- CBNumber
- CB2314673
- Molecular Formula
- C9H6BrN
- Formula Weight
- 208.05
- MOL File
- 5332-25-2.mol
6-Bromoquinoline Property
- Melting point:
- 19°C
- Boiling point:
- 116 °C / 6mmHg
- Density
- 1.538 g/mL at 25 °C
- refractive index
- n20/D 1.663
- Flash point:
- 19 °C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Soluble in acetone, acetonitrile, dichloromethane, ethyl acetate and THF.
- pka
- 4.18±0.10(Predicted)
- form
- Oil
- InChIKey
- IFIHYLCUKYCKRH-UHFFFAOYSA-N
- CAS DataBase Reference
- 5332-25-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 6-Bromo quinoline(5332-25-2)
- EPA Substance Registry System
- Quinoline, 6-bromo- (5332-25-2)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-41-37/38-22-20/21/22
- Safety Statements
- 26-37/39-39-36
- WGK Germany
- 3
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29334900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 697893
- Product name
- 6-Bromoquinoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $32.6
- Updated
- 2022/05/15
- Product number
- 697893
- Product name
- 6-Bromoquinoline
- Purity
- 97%
- Packaging
- 5g
- Price
- $113
- Updated
- 2022/05/15
- Product number
- B2015
- Product name
- 6-Bromoquinoline
- Purity
- >95.0%(GC)
- Packaging
- 1g
- Price
- $22
- Updated
- 2024/03/01
- Product number
- B2015
- Product name
- 6-Bromoquinoline
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $63
- Updated
- 2024/03/01
- Product number
- H55111
- Product name
- 6-Bromoquinoline, 97%
- Packaging
- 1g
- Price
- $38.65
- Updated
- 2024/03/01
6-Bromoquinoline Chemical Properties,Usage,Production
Bromoquinoline
There are seven positional isomers of bromoquinoline and their main properties are listed below:
Application and synthetic method
3-bromo-quinoline is reacted with mixed acid for generating 3-bromo-5-nitro-quinoline, which heats together with potassium permanganate for being oxidation into 5-bromo-2, 3-pyridine dicarboxylic acid.
6-bromo-quinoline is heated together with nitric acid to generate 6-bromo-8-nitro quinolone with further reaction with potassium permanganate for being oxidized to 2, 3-pyridinedicarboxylic acid.
2-bromo-quinolien can be synthesized through the reaction between 2-hydroxy quinoline and phosphorus pentabromide.
Quinoline perbromide is heated at 180 °C for generating 3-bromo-quinoline.
From the heating between 4-hydroxy quinoline and phosphorus pentabromide, or from the diazotization reaction via 4-aminoquinoline to generate 4-bromo-quinoline;
5-bromo-quinoline is synthesize by the heating reaction between m-bromo-aniline, glycerol, m-bromo nitrobenzene and concentrated sulfuric acid, or from the diazotization reaction of 5-aminoquinoline.
6-bromo-quinoline can be synthesized from the heating of bromoaniline, glycerol, concentrated sulfuric acid, and p-bromo-nitrobenzene.
7-bromo-quinoline can be synthesized from the diazotization reaction of 7-aminoquinoline.
8-bromo-quinoline can be synthesized from the heating reaction of o-bromo-aniline, glycerol, concentrated sulfuric acid and o-bromo nitrobenzene.
application: as organic synthesis reagents.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Chemical Properties
Thick Oil
Uses
6-Bromoquinoline is used as fine chemical and pharmaceutical intermediate, used as the coupling reagent.
Synthesis
4-Bromobenzenamine (25 g, 145.32 mmol, 1.00 equiv), sodium 3-nitrobenzenesulfonate (55.5 g, 246.64 mmol, 1.70 equiv), propane-1,2,3-triol (50.8 g, 551.63 mmol, 3.80 equiv), and sulfuric acid (170 mL, 70%) were placed into a 500-mL round-bottom flask. The resulting solution was stirred overnight at 140° C. The pH value of the solution was adjusted to with 10% aqueous sodium hydroxide. The resulting solution was extracted with 5*150 mL of ethyl acetate. The organic layers were combined and dried over anhydrous sodium sulfate, and concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with ethyl acetate/petroleum ether (1:50). This resulted in 17.2 g (42%) of 6-bromoquinoline as yellow oil.
6-Bromoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Bromoquinoline manufacturers
- Product
- 6-Bromoquinoline 5332-25-2
- Price
- US $5.00/kg
- Min. Order
- 1kg
- Purity
- 99.92%
- Supply Ability
- 50000tons
- Release date
- 2024-04-24
- Product
- 6-Bromoquinoline 5332-25-2
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 6-Bromoquinoline 5332-25-2
- Price
- US $32.00-266.00/g
- Min. Order
- 25g
- Purity
- 0.97
- Supply Ability
- 25kg
- Release date
- 2023-12-14