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N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide

Product Name
N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
CAS No.
796-42-9
Chemical Name
N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
Synonyms
AS8351;NSC51355;NSC-51355;NSC 51355;AS8351;AS 8351;NSC51355;NSC 51355;NSC-51355;N'-[(2-Hydroxy-1-naphthyl)methylene]isonicotinohydrazide;N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide;N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide;NSC-51355,NSC 51355,Histone Demethylase,AS8351,inhibit,Inhibitor;N-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide
CBNumber
CB23166598
Molecular Formula
C17H13N3O2
Formula Weight
291.3
MOL File
796-42-9.mol
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N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in DMSO (45 mg/ml); ethanol (10 mg/ml with warming)
form 
solid
color 
Yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1692
Product name
AS8351
Purity
≥98% (HPLC)
Packaging
5MG
Price
$108
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1692
Product name
AS8351
Purity
≥98% (HPLC)
Packaging
25MG
Price
$424
Updated
2023/01/07
Cayman Chemical
Product number
20811
Product name
AS-8351
Purity
≥98%
Packaging
5mg
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
20811
Product name
AS-8351
Purity
≥98%
Packaging
10mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
20811
Product name
AS-8351
Purity
≥98%
Packaging
25mg
Price
$221
Updated
2024/03/01
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N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide Chemical Properties,Usage,Production

Description

AS-8351 is a histone demethylase inhibitor. It has been used in combination with CHIR99021 , A 83-01 , BIX01294 , SC-1 , Y-27632 (Item No. 10005583), OAC2 , SU 16f , and JNJ-10198409 to induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.

Uses

AS 8351 is used in the conversion of human fibroblasts into functional cardiomyocytes, which provides a promising source for regenerative therapy.

in vitro

in a previous study, in order to identify indispensable factors for human fibroblasts, the authors removed combined compounds one by one and treated cells with the remaining compounds. results showed that the number of beating clusters was significantly reduced by removal of seven compounds including as8351. moreover, these seven compounds inlcuding as8351 were sufficient and necessary to induce cardiac reprogramming efficiently. the authors then investigated the role of the reprogramming compound of as8351 and the results showed that as8351 and its functional analogs could affect epigenetic modifications by competing with α- ketoglutarate for chelating iron/fe(ii) in some epigenetic enzymes, including the jmjc-domain-containing histone demethylases that require α-kg and iron as co-factors. in addition, the authors abrogated each of the 22 genes in the jmjc-kdm family by small hairpin rnas and found that only with kdm5b knockdown, or using a kdm5b inhibitor, pbit could phenocopy as8351 in generating cicms, indicating that it might be a target of as8351 [1].

References

1) Cao et al. (2016), Conversion of human fibroblasts into functional cardiomyocytes by small molecules; Science, 352 1216

N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide Suppliers

Americas 1 China 55 Europe 1 India 2 Japan 1 United Kingdom 1 United States 12 USA 1 Global 74
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
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View Lastest Price from N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide manufacturers

Career Henan Chemical Co
Product
N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide 796-42-9
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-24

796-42-9, N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazideRelated Search:

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  • AS8351
  • N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
  • NSC-51355
  • AS8351;AS 8351;NSC51355;NSC 51355;NSC-51355
  • NSC 51355
  • NSC51355
  • N'-[(2-hydroxynaphthalen-1-yl)methylidene]pyridine-4-carbohydrazide
  • N-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide
  • 4-Pyridinecarboxylic acid, 2-[(2-hydroxy-1-naphthalenyl)methylene]hydrazide
  • N'-[(2-Hydroxy-1-naphthyl)methylene]isonicotinohydrazide
  • NSC-51355,NSC 51355,Histone Demethylase,AS8351,inhibit,Inhibitor
  • N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
  • 796-42-9
  • API