N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
- Product Name
- N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
- CAS No.
- 796-42-9
- Chemical Name
- N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
- Synonyms
- AS8351;NSC51355;NSC-51355;NSC 51355;AS8351;AS 8351;NSC51355;NSC 51355;NSC-51355;N'-[(2-Hydroxy-1-naphthyl)methylene]isonicotinohydrazide;N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide;N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide;NSC-51355,NSC 51355,Histone Demethylase,AS8351,inhibit,Inhibitor;N-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide
- CBNumber
- CB23166598
- Molecular Formula
- C17H13N3O2
- Formula Weight
- 291.3
- MOL File
- 796-42-9.mol
N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Soluble in DMSO (45 mg/ml); ethanol (10 mg/ml with warming)
- form
- solid
- color
- Yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1692
- Product name
- AS8351
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $108
- Updated
- 2024/03/01
- Product number
- SML1692
- Product name
- AS8351
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $424
- Updated
- 2023/01/07
- Product number
- 20811
- Product name
- AS-8351
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 20811
- Product name
- AS-8351
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 20811
- Product name
- AS-8351
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $221
- Updated
- 2024/03/01
N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide Chemical Properties,Usage,Production
Description
AS-8351 is a histone demethylase inhibitor. It has been used in combination with CHIR99021 , A 83-01 , BIX01294 , SC-1 , Y-27632 (Item No. 10005583), OAC2 , SU 16f , and JNJ-10198409 to induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.
Uses
AS 8351 is used in the conversion of human fibroblasts into functional cardiomyocytes, which provides a promising source for regenerative therapy.
in vitro
in a previous study, in order to identify indispensable factors for human fibroblasts, the authors removed combined compounds one by one and treated cells with the remaining compounds. results showed that the number of beating clusters was significantly reduced by removal of seven compounds including as8351. moreover, these seven compounds inlcuding as8351 were sufficient and necessary to induce cardiac reprogramming efficiently. the authors then investigated the role of the reprogramming compound of as8351 and the results showed that as8351 and its functional analogs could affect epigenetic modifications by competing with α- ketoglutarate for chelating iron/fe(ii) in some epigenetic enzymes, including the jmjc-domain-containing histone demethylases that require α-kg and iron as co-factors. in addition, the authors abrogated each of the 22 genes in the jmjc-kdm family by small hairpin rnas and found that only with kdm5b knockdown, or using a kdm5b inhibitor, pbit could phenocopy as8351 in generating cicms, indicating that it might be a target of as8351 [1].
References
1) Cao et al. (2016), Conversion of human fibroblasts into functional cardiomyocytes by small molecules; Science, 352 1216
N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide Suppliers
View Lastest Price from N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide manufacturers
- Product
- N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide 796-42-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24