Troxerutin
- Product Name
- Troxerutin
- CAS No.
- 7085-55-4
- Chemical Name
- Troxerutin
- Synonyms
- Troxerutine;Venoruton;Troxerutin CRS;RUVEN;95%UV;Z-6000;95% UV;Qucrutin;Rufen P-4;VASTRIBIL
- CBNumber
- CB2317568
- Molecular Formula
- C33H42O19
- Formula Weight
- 742.68
- MOL File
- 7085-55-4.mol
Troxerutin Property
- Melting point:
- 181°C
- Boiling point:
- 1058.4±65.0 °C(Predicted)
- Density
- 1.65±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Freely soluble in water, slightly soluble in ethanol (96 per cent) and practically insoluble in methylene chloride.
- form
- Solid
- pka
- 5.92±0.40(Predicted)
- color
- Light Yellow to Yellow
- Merck
- 14,9789
- BRN
- 4778232
- InChI
- InChI=1/C33H42O19/c1-14-23(38)26(41)28(43)32(49-14)48-13-21-24(39)27(42)29(44)33(51-21)52-31-25(40)22-17(37)11-16(45-7-4-34)12-20(22)50-30(31)15-2-3-18(46-8-5-35)19(10-15)47-9-6-36/h2-3,10-12,14,21,23-24,26-29,32-39,41-44H,4-9,13H2,1H3/t14-,21+,23-,24+,26+,27-,28+,29+,32+,33-/s3
- InChIKey
- KMPBUGGPUQOWMJ-NXPSPVSKSA-N
- SMILES
- O([C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)O1)O)C1C(C2=C(C=C(OCCO)C=C2OC=1C1C=CC(OCCO)=C(OCCO)C=1)O)=O |&1:1,2,3,5,7,10,12,14,16,18,r|
- CAS DataBase Reference
- 7085-55-4(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- LK8331500
- HS Code
- 2938100000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Y0000497
- Product name
- Troxerutin
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000497
- Price
- $220
- Updated
- 2024/03/01
- Product number
- PHR2815
- Product name
- Troxerutin
- Purity
- certified reference material, pharmaceutical secondary standard
- Packaging
- 50MG
- Price
- $365
- Updated
- 2024/03/01
- Product number
- T3541
- Product name
- Troxerutin
- Purity
- >90.0%(HPLC)
- Packaging
- 5g
- Price
- $52
- Updated
- 2024/03/01
- Product number
- T3541
- Product name
- Troxerutin
- Purity
- >90.0%(HPLC)
- Packaging
- 25g
- Price
- $154
- Updated
- 2024/03/01
- Product number
- 27220
- Product name
- Troxerutin
- Packaging
- 10g
- Price
- $55
- Updated
- 2024/03/01
Troxerutin Chemical Properties,Usage,Production
Chemical Properties
Yellow Powder
Originator
Venoruton,Novartis Co
Uses
Used in the treatment of venous disorders
Uses
vasoprotectant
Uses
Troxerutin, a derivative of the naturally occurring bioflavonoid rutin, is thought to inhibit red cell and platelet aggregation, improve erythrocyte deformability, and improve plasma viscosity retinal microcirculation. A double-blind randomized clinical trial compared troxerutin with placebo in 27 patients with CRVO. The limitations of the study included a small number of patients and short follow-up time.
Manufacturing Process
In a nitrogen atmosphere 120 g of caustic soda (3 moles) in solution are added to 610 g of rutin (1 mol) suspended in 2 litres of water, the mixture being vigorously agitated by a mechanical stirrer, 241.5 g of ethylene chlorohydrin being then introduced at 55°C for 10 min. When all the chlorohydrin has been thus added the temperature is progressively raised to 75°C and maintained at this level for 2 hours. After cooling, in a nitrogen atmosphere, the pH value adjusted to 5 by the addition of dilute hydrochloric acid. The solution is kept in an ice box for 24 hours and then filtered to remove any impurities. At reduced pressure the solution is evaporated until dry, the residue taken up in 3 litres of boning methanol which dissolves the tri-(β-hydroxyethyl)rutin formed and leaves the sparingly soluble sodium chloride behind. The tri-(β-hydroxyethyl)rutin is recovered from its methanolic solution either by evaporation and refrigeration, or by evaporation precipitation with absolute ethanol. In either case tri-(β-hydroxyethyl)rutin obtained is in the form of small very hygroscopic crystals which contain alcohol of crystallization.These crystals are quickly shaken washed in a little cold absolute ethanol and then dried in vacuum at 100°C. 680 g of anhydrous tri-(β-hydroxyethyl)rutin are thus obtained in the form of a yellow powder which melts at 156°C.GB Patent No. 833,174; April 21, 1960; Assigned to Zyma S.A., a Swiss Corporation, of Route Etraz, Nyon Canton of Vaud, Switzerland
Therapeutic Function
Topical venotonic
target
VEGFR | Wnt/β-catenin | NF-kB | SOD | PI3K | Akt
Troxerutin Preparation Products And Raw materials
Raw materials
Preparation Products
Troxerutin Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
View Lastest Price from Troxerutin manufacturers
- Product
- Troxerutin 7085-55-4
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-11-14
- Product
- Troxerutin 7085-55-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000 kg
- Release date
- 2024-11-22
- Product
- Troxerutin 7085-55-4
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min; EP
- Supply Ability
- 500KG
- Release date
- 2021-06-02