ChemicalBook > CAS DataBase List > 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER
4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER
- Product Name
- 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER
- CAS No.
- 23851-84-5
- Chemical Name
- 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER
- Synonyms
- AKOS BBS-00002777;BUTTPARK 10\01-31;4-Hydroxy-8-(trifluoromethyl)quinoline-3-;ETHYL 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE;ETHYL 4-HYDROXY-8-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE;ethyl 4-oxo-8-(trifluoromethyl)-1H-quinoline-3-carboxylate;2-ethyl-4-oxo-8-(trifluoromethyl)-1H-quinoline-3-carboxylate;4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER;4-hydroxy-8-(trifluoromethyl)-3-quinolinecarboxylicaciethylester;4-hydroxy-8-(trifluoromethyl)-3-quinolinecarboxylicacidethylester
- CBNumber
- CB2321655
- Molecular Formula
- C13H10F3NO3
- Formula Weight
- 285.22
- MOL File
- 23851-84-5.mol
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4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER Property
- Melting point:
- 216 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 343.5±37.0 °C(Predicted)
- Density
- 1.404±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 1.84±0.50(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 23851-84-5(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933499090
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N-Bromosuccinimide Price
TRC
- Product number
- E936968
- Product name
- Ethyl4-Hydroxy-8-(trifluoromethyl)-3-quinolinecarboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 007024
- Product name
- Ethyl 4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 007024
- Product name
- Ethyl 4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $124
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC8131
- Product name
- Ethyl4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
AK Scientific
- Product number
- V4594
- Product name
- Ethyl4-hydroxy-8-trifluoromethylquinoline-3-carboxylate
- Packaging
- 10g
- Price
- $308
- Updated
- 2021/12/16
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4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
23779-94-4
23851-84-5
GENERAL METHOD: Diethyl [[[(trifluoromethyl)phenyl]amino}methylene]malonate (10.0 g, 0.030 mol) was mixed with Dowtherm (100 mL), heated to 250 °C and maintained at this temperature for 5 hours of reaction. Upon completion of the reaction, the mixture was cooled to 25 °C, followed by the addition of 150 mL of hexane and stirred for 10 minutes. The resulting solid product was collected by filtration and dried. The crude product was further purified by column chromatography with the eluent being a solvent mixture of petroleum ether and ethyl acetate (5:5, v/v), resulting in ethyl 4-hydroxy-8-trifluoromethylquinoline-3-carboxylate in white solid form.
References
[1] European Journal of Medicinal Chemistry, 2013, vol. 68, p. 422 - 432
[2] European Journal of Medicinal Chemistry, 2014, vol. 74, p. 324 - 332
[3] Patent: US2005/131014, 2005, A1. Location in patent: Page/Page column 28
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 3, p. 1040 - 1044
[5] Organic Process Research and Development, 2014, vol. 18, # 11, p. 1482 - 1491
4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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23851-84-5, 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTERRelated Search:
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