ChemicalBook > CAS DataBase List > 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER

4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER

Product Name
4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER
CAS No.
23851-84-5
Chemical Name
4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER
Synonyms
AKOS BBS-00002777;BUTTPARK 10\01-31;4-Hydroxy-8-(trifluoromethyl)quinoline-3-;ETHYL 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE;ETHYL 4-HYDROXY-8-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE;ethyl 4-oxo-8-(trifluoromethyl)-1H-quinoline-3-carboxylate;2-ethyl-4-oxo-8-(trifluoromethyl)-1H-quinoline-3-carboxylate;4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER;4-hydroxy-8-(trifluoromethyl)-3-quinolinecarboxylicaciethylester;4-hydroxy-8-(trifluoromethyl)-3-quinolinecarboxylicacidethylester
CBNumber
CB2321655
Molecular Formula
C13H10F3NO3
Formula Weight
285.22
MOL File
23851-84-5.mol
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4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER Property

Melting point:
216 °C(Solv: ethanol (64-17-5))
Boiling point:
343.5±37.0 °C(Predicted)
Density 
1.404±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
1.84±0.50(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
23851-84-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Hazard Note 
Irritant
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
E936968
Product name
Ethyl4-Hydroxy-8-(trifluoromethyl)-3-quinolinecarboxylate
Packaging
50mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
007024
Product name
Ethyl 4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate
Purity
97%
Packaging
1g
Price
$49
Updated
2021/12/16
Matrix Scientific
Product number
007024
Product name
Ethyl 4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate
Purity
97%
Packaging
5g
Price
$124
Updated
2021/12/16
Apolloscientific
Product number
PC8131
Product name
Ethyl4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate
Packaging
1g
Price
$10
Updated
2021/12/16
AK Scientific
Product number
V4594
Product name
Ethyl4-hydroxy-8-trifluoromethylquinoline-3-carboxylate
Packaging
10g
Price
$308
Updated
2021/12/16
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4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

23779-94-4

23851-84-5

GENERAL METHOD: Diethyl [[[(trifluoromethyl)phenyl]amino}methylene]malonate (10.0 g, 0.030 mol) was mixed with Dowtherm (100 mL), heated to 250 °C and maintained at this temperature for 5 hours of reaction. Upon completion of the reaction, the mixture was cooled to 25 °C, followed by the addition of 150 mL of hexane and stirred for 10 minutes. The resulting solid product was collected by filtration and dried. The crude product was further purified by column chromatography with the eluent being a solvent mixture of petroleum ether and ethyl acetate (5:5, v/v), resulting in ethyl 4-hydroxy-8-trifluoromethylquinoline-3-carboxylate in white solid form.

References

[1] European Journal of Medicinal Chemistry, 2013, vol. 68, p. 422 - 432
[2] European Journal of Medicinal Chemistry, 2014, vol. 74, p. 324 - 332
[3] Patent: US2005/131014, 2005, A1. Location in patent: Page/Page column 28
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 3, p. 1040 - 1044
[5] Organic Process Research and Development, 2014, vol. 18, # 11, p. 1482 - 1491

4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER Suppliers

China 54 Germany 2 India 1 United Kingdom 7 United States 12 Global 76
Service Chemical Inc.
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sales@chemos-group.com
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Germany
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AKos Consulting & Solutions GmbH
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akos@akosgmbh.de
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23851-84-5, 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTERRelated Search:

ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE 4-HYDROXY-8-METHYLQUINOLINE 8-METHYL-QUINOLINE-3-CARBOXYLIC ACID 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER 8-(TRIFLUOROMETHYL)QUINOLIN-4-OL 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ACID METHYL 3-(TRIFLUOROMETHYL)BENZOYLACETATE 4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 3-OXO-3-(3-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER 8-Trifluoromethylquinoline 4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ACID 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 4-HYDROXY-8-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

  • 4-hydroxy-8-(trifluoromethyl)-3-quinolinecarboxylicacidethylester
  • 4-hydroxy-8-(trifluoromethyl)-3-quinolinecarboxylicaciethylester
  • BUTTPARK 10\01-31
  • ETHYL 4-HYDROXY-8-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE
  • ETHYL 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE
  • Ethyl 4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate
  • 4-HYDROXY-8-TRIFLUOROMETHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
  • 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER
  • AKOS BBS-00002777
  • 4-Hydroxy-8-(trifluoromethyl)quinoline-3-
  • 3-(Ethoxycarbonyl)-4-hydroxy-8-(trifluoromethyl)quinoline, 3-(Ethoxycarbonyl)-4-hydroxy-8-(trifluoromethyl)-1-azanaphthalene
  • ethyl 4-oxo-8-(trifluoromethyl)-1H-quinoline-3-carboxylate
  • 2-ethyl-4-oxo-8-(trifluoromethyl)-1H-quinoline-3-carboxylate
  • 3-Quinolinecarboxylic acid, 4-hydroxy-8-(trifluoromethyl)-, ethyl ester
  • 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER ISO 9001：2015 REACH
  • 23851-84-5
  • 23851-84-8
  • C13H10F3NO3
  • blocks
  • Carboxes
  • Quinolines
  • Acids and Derivatives
  • Heterocycles
  • Quinoline&Isoquinoline