ISOPROPYLSULFONYL CHLORIDE
- Product Name
- ISOPROPYLSULFONYL CHLORIDE
- CAS No.
- 10147-37-2
- Chemical Name
- ISOPROPYLSULFONYL CHLORIDE
- Synonyms
- 2-PropanesuL;SOPROPYLSULFONYL CHLORIDE;ISOPROPYLSULFONYL CHLORIDE;2-PROPANESULFONYL CHLORIDE;Isopropylsulphonyl choride;ISOPROPYLSULPHONYL CHLORIDE;2-PROPANESULPHONYL CHLORIDE;PROPANE-2-SULFONYL CHLORIDE;IsopropylsulfonylChloride>2-Propanesulfonyl chloride,97%
- CBNumber
- CB2322263
- Molecular Formula
- C3H7ClO2S
- Formula Weight
- 142.6
- MOL File
- 10147-37-2.mol
ISOPROPYLSULFONYL CHLORIDE Property
- Melting point:
- -47°C
- Boiling point:
- 74-75 °C/19 mmHg (lit.)
- Density
- 1.27 g/mL at 25 °C (lit.)
- vapor density
- 4 (vs air)
- vapor pressure
- 15.5 mm Hg ( 25 °C)
- refractive index
- n20/D 1.453(lit.)
- Flash point:
- 187 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Acetontrile (Slightly), Chloroform (Slightly)
- form
- clear liquid
- color
- Colorless to Light yellow to Light orange
- Specific Gravity
- 1.270
- Water Solubility
- Reacts with water.
- Sensitive
- Lachrymatory
- BRN
- 1747497
- CAS DataBase Reference
- 10147-37-2(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-R34
- Safety Statements
- 26-28-36/37/39-45-S45-S36/37/39-S28-S26
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- F
- 13-19-21
- Autoignition Temperature
- 865 °F
- Hazard Note
- Lachrymatory/Corrosive
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29049090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 242705
- Product name
- 2-Propanesulfonyl chloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $52.25
- Updated
- 2025/07/31
- Product number
- 242705
- Product name
- 2-Propanesulfonyl chloride
- Purity
- 97%
- Packaging
- 25g
- Price
- $94.7
- Updated
- 2025/07/31
- Product number
- I0291
- Product name
- Isopropylsulfonyl Chloride
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- I0291
- Product name
- Isopropylsulfonyl Chloride
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $164
- Updated
- 2025/07/31
- Product number
- 242705
- Product name
- 2-Propanesulfonyl chloride
- Purity
- 97%
- Packaging
- 100g
- Price
- $352
- Updated
- 2025/07/31
ISOPROPYLSULFONYL CHLORIDE Chemical Properties,Usage,Production
Chemical Properties
Clear pale yellow-greenish liquid
Uses
2-Propanesulfonyl chloride is used as a pharmaceutical intermediate. Reductive cleavage of a secondary alcohol to methylene has been achieved by reduction of the 2-propanesulfonyl ester with lithium triethylborohydride.
Uses
2-Propanesulfonyl chloride (isopropylsulfonyl chloride) can be used as a reactant to prepare:
- 1-Isopropylsulfonyl-2-amine benzimidazole by reacting with 2-aminobenzimidazole via N-sulfonylation reaction in the presence of a base.
- Bis(isopropylsulfonyl)disulfide, a sulfurizing agent, used to synthesize phosphorothioate oligonucleotide analogs.
General Description
The solvolysis of 2-propanesulfonyl chloride by an addition-elimination (association-dissociation) pathway was studied.
Synthesis
75-33-2
10147-37-2
The general procedure for the synthesis of isopropylsulfonyl chloride from isopropyl mercaptan is as follows: a solution of isopropyl mercaptan (1 eq.) and isopropanol (2 eq.) was stirred in dichloromethane (0.15 M). Subsequently, N-bromosuccinimide (4 eq.) or N-chlorosuccinimide (3.5 eq.) was added in batches at room temperature (when N-bromosuccinimide was used) or at 0 °C (when N-chlorosuccinimide was used). The reaction mixture was stirred at room temperature until the starting material was undetectable by thin layer chromatography (TLC) (about 1 hour). After completion of the reaction, the reaction mixture was diluted with cold saturated sodium bicarbonate solution and extracted with ethyl acetate (four times). The organic extracts were combined, dried with sodium sulfate and subsequently concentrated under vacuum to give the crude product. Finally, pure isopropylsulfonyl chloride was purified by silica gel column chromatography or radial chromatography using a hexane/ethyl acetate/acetone solvent mixture as eluent to give pure isopropylsulfonyl chloride.
References
[1] Chemistry Letters, 1992, # 8, p. 1483 - 1486
[2] Tetrahedron Letters, 2017, vol. 58, # 23, p. 2244 - 2247
[3] Journal fuer Praktische Chemie (Leipzig), 1979, vol. 321, p. 279 - 292
[4] Journal fuer Praktische Chemie (Leipzig), 1969, vol. 311, p. 596 - 603
[5] Journal fuer Praktische Chemie/Chemiker-Zeitung, 1992, vol. 334, # 3, p. 251 - 256
ISOPROPYLSULFONYL CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ISOPROPYLSULFONYL CHLORIDE manufacturers
- Product
- ISOPROPYLSULFONYL CHLORIDE 10147-37-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-08-07