ChemicalBook > CAS DataBase List > ISOPROPYLSULFONYL CHLORIDE

ISOPROPYLSULFONYL CHLORIDE

Product Name
ISOPROPYLSULFONYL CHLORIDE
CAS No.
10147-37-2
Chemical Name
ISOPROPYLSULFONYL CHLORIDE
Synonyms
2-PropanesuL;SOPROPYLSULFONYL CHLORIDE;ISOPROPYLSULFONYL CHLORIDE;2-PROPANESULFONYL CHLORIDE;Isopropylsulphonyl choride;Propan-2-sulfonyl chloride;ISOPROPYLSULPHONYL CHLORIDE;2-PROPANESULPHONYL CHLORIDE;PROPANE-2-SULFONYL CHLORIDE;IsopropylsulfonylChloride>
CBNumber
CB2322263
Molecular Formula
C3H7ClO2S
Formula Weight
142.6
MOL File
10147-37-2.mol
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ISOPROPYLSULFONYL CHLORIDE Property

Melting point:
-47°C
Boiling point:
74-75 °C/19 mmHg (lit.)
Density 
1.27 g/mL at 25 °C (lit.)
vapor density 
4 (vs air)
vapor pressure 
15.5 mm Hg ( 25 °C)
refractive index 
n20/D 1.453(lit.)
Flash point:
187 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Acetontrile (Slightly), Chloroform (Slightly)
form 
clear liquid
color 
Colorless to Light yellow to Light orange
Specific Gravity
1.270
Water Solubility 
Reacts with water.
Sensitive 
Lachrymatory
BRN 
1747497
CAS DataBase Reference
10147-37-2(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34-R34
Safety Statements 
26-28-36/37/39-45-S45-S36/37/39-S28-S26
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
F 
13-19-21
Autoignition Temperature
865 °F
Hazard Note 
Lachrymatory/Corrosive
HazardClass 
8
PackingGroup 
II
HS Code 
29049090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
242705
Product name
2-Propanesulfonyl chloride
Purity
97%
Packaging
5g
Price
$52.25
Updated
2025/07/31
Sigma-Aldrich
Product number
242705
Product name
2-Propanesulfonyl chloride
Purity
97%
Packaging
25g
Price
$94.7
Updated
2025/07/31
TCI Chemical
Product number
I0291
Product name
Isopropylsulfonyl Chloride
Purity
>95.0%(GC)
Packaging
5g
Price
$45
Updated
2025/07/31
TCI Chemical
Product number
I0291
Product name
Isopropylsulfonyl Chloride
Purity
>95.0%(GC)
Packaging
25g
Price
$164
Updated
2025/07/31
Sigma-Aldrich
Product number
242705
Product name
2-Propanesulfonyl chloride
Purity
97%
Packaging
100g
Price
$352
Updated
2025/07/31
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ISOPROPYLSULFONYL CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Clear pale yellow-greenish liquid

Uses

2-Propanesulfonyl chloride is used as a pharmaceutical intermediate. Reductive cleavage of a secondary alcohol to methylene has been achieved by reduction of the 2-propanesulfonyl ester with lithium triethylborohydride.

Uses

2-Propanesulfonyl chloride (isopropylsulfonyl chloride) can be used as a reactant to prepare:

  • 1-Isopropylsulfonyl-2-amine benzimidazole by reacting with 2-aminobenzimidazole via N-sulfonylation reaction in the presence of a base.
  • Bis(isopropylsulfonyl)disulfide, a sulfurizing agent, used to synthesize phosphorothioate oligonucleotide analogs.

General Description

The solvolysis of 2-propanesulfonyl chloride by an addition-elimination (association-dissociation) pathway was studied.

Synthesis

75-33-2

10147-37-2

The general procedure for the synthesis of isopropylsulfonyl chloride from isopropyl mercaptan is as follows: a solution of isopropyl mercaptan (1 eq.) and isopropanol (2 eq.) was stirred in dichloromethane (0.15 M). Subsequently, N-bromosuccinimide (4 eq.) or N-chlorosuccinimide (3.5 eq.) was added in batches at room temperature (when N-bromosuccinimide was used) or at 0 °C (when N-chlorosuccinimide was used). The reaction mixture was stirred at room temperature until the starting material was undetectable by thin layer chromatography (TLC) (about 1 hour). After completion of the reaction, the reaction mixture was diluted with cold saturated sodium bicarbonate solution and extracted with ethyl acetate (four times). The organic extracts were combined, dried with sodium sulfate and subsequently concentrated under vacuum to give the crude product. Finally, pure isopropylsulfonyl chloride was purified by silica gel column chromatography or radial chromatography using a hexane/ethyl acetate/acetone solvent mixture as eluent to give pure isopropylsulfonyl chloride.

References

[1] Chemistry Letters, 1992, # 8, p. 1483 - 1486
[2] Tetrahedron Letters, 2017, vol. 58, # 23, p. 2244 - 2247
[3] Journal fuer Praktische Chemie (Leipzig), 1979, vol. 321, p. 279 - 292
[4] Journal fuer Praktische Chemie (Leipzig), 1969, vol. 311, p. 596 - 603
[5] Journal fuer Praktische Chemie/Chemiker-Zeitung, 1992, vol. 334, # 3, p. 251 - 256

ISOPROPYLSULFONYL CHLORIDE Preparation Products And Raw materials

Raw materials

Acetonitrile 2-Propanethiol Thionyl chloride Potassium nitrate

Preparation Products

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View Lastest Price from ISOPROPYLSULFONYL CHLORIDE manufacturers

Career Henan Chemical Co
Product
ISOPROPYLSULFONYL CHLORIDE 10147-37-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2019-08-07

10147-37-2, ISOPROPYLSULFONYL CHLORIDERelated Search:

ISOPROPYLHYDRAZINE HYDROCHLORIDE Isopropylboronic acid 2-Propanethiol Diisopropyl ether IPTG ISOPROPYLUREA Cyclohexanesulfonyl chloride 4-CHLOROSULFONYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER BUTANE-2-SULFONYL CHLORIDE N-BENZYLOXYCARBONYL-4-PIPERIDINESULFONYL CHLORIDE CYCLOPENTANESULFONYL CHLORIDE ISOPROPYLSULFONYL CHLORIDE Cyclopropanesulfonyl chloride 2-PENTYL SULFONYL CHLORIDE Tetrahydropyran-4-SulfonylChloride 1-Propanesulfonyl chloride Tetrahydro-3-thiophenesulfonyl chloride 1,1-dioxide 2-(4-FLUORO-PHENYL)-CYCLOPROPANESULFONYL CHLORIDE

  • PROPANE-2-SULFONYL CHLORIDE
  • 2-PropanesuL
  • 2-PROPANESULFONYL CHLORIDE
  • 2-PROPANESULPHONYL CHLORIDE
  • Isopropylsulfonyl chloride ,95%
  • 1-Methylethanesulfonic acid chloride
  • 1-Methylethanesulfonyl chloride
  • Propane-2-sulfonic acid chloride
  • 2-Propanesulfonyl chloride,97%
  • ISOPROPYLSULFONYL CHLORIDE
  • ISOPROPYLSULPHONYL CHLORIDE
  • Isopropylsulphonyl choride
  • 2-Propanesulfonyl chloride 97%
  • SOPROPYLSULFONYL CHLORIDE
  • Isopropylsulfonyl chloride ,98%
  • IsopropylsulfonylChloride&gt
  • 2-Propanesulfonyl chloride, 97%, for synthesis
  • 2-Propanesulfonyl chloride (7CI, 9CI, ACI)
  • Propan-2-sulfonyl chloride
  • 10147-37-2
  • C3Cl1H7O2S1
  • CH32CHSO2Cl
  • SULFONYL CHLORIDE
  • Building Blocks
  • Sulfonyl Halides
  • Sulfur Compounds
  • Organic Building Blocks
  • Organic Building Blocks
  • Sulfonyl Halides
  • Sulfur Compounds