4-Hydroxy-4'-isopropoxydiphenylsulfone
- Product Name
- 4-Hydroxy-4'-isopropoxydiphenylsulfone
- CAS No.
- 95235-30-6
- Chemical Name
- 4-Hydroxy-4'-isopropoxydiphenylsulfone
- Synonyms
- BPS-monoP;UBA7;UBE2;D-8.;UBE1L;UBA1B;D8(HPS);MGC12713;WinCon-8;F-108(D-8)
- CBNumber
- CB2324449
- Molecular Formula
- C15H16O4S
- Formula Weight
- 292.35
- MOL File
- 95235-30-6.mol
4-Hydroxy-4'-isopropoxydiphenylsulfone Property
- Melting point:
- 129 °C
- Boiling point:
- 478.8±30.0 °C(Predicted)
- Density
- 1.251±0.06 g/cm3(Predicted)
- vapor pressure
- 0Pa at 27℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 0.891 in mg/100g standard fat at 20 ℃
- form
- powder to crystal
- pka
- 7.24±0.15(Predicted)
- color
- White to Almost white
- Water Solubility
- 19.7mg/L at 25℃
- InChI
- InChI=1S/C15H16O4S/c1-11(2)19-13-5-9-15(10-6-13)20(17,18)14-7-3-12(16)4-8-14/h3-11,16H,1-2H3
- InChIKey
- ZTILAOCGFRDHBH-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(S(C2=CC=C(OC(C)C)C=C2)(=O)=O)C=C1
- LogP
- 3.36 at 25℃
- CAS DataBase Reference
- 95235-30-6(CAS DataBase Reference)
- EPA Substance Registry System
- Phenol, 4-[[4-(1-methylethoxy)phenyl]sulfonyl]- (95235-30-6)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SAB5300007
- Product name
- Monoclonal Anti-UBA7 antibody produced in mouse
- Purity
- clone 5B10, ascites fluid
- Packaging
- 100μL
- Price
- $503
- Updated
- 2023/01/07
- Product number
- SAB1307068
- Product name
- ANTI-UBA7(N-TERMINAL) antibody produced in rabbit
- Purity
- affinity isolated antibody, buffered aqueous solution
- Packaging
- 400μL
- Price
- $461
- Updated
- 2023/01/07
- Product number
- I1045
- Product name
- 4-[(4-Isopropoxyphenyl)sulfonyl]phenol
- Packaging
- 5G
- Price
- $59
- Updated
- 2025/07/31
- Product number
- I1045
- Product name
- 4-[(4-Isopropoxyphenyl)sulfonyl]phenol
- Packaging
- 25G
- Price
- $203
- Updated
- 2025/07/31
- Product number
- 134984
- Product name
- UBA7
- Packaging
- 50ug
- Price
- $539
- Updated
- 2021/12/16
4-Hydroxy-4'-isopropoxydiphenylsulfone Chemical Properties,Usage,Production
Uses
For color developing dyes, various types of dye such as fluoran, phthalide, lactam, triphenylmethane, spiropyran and other types of leuco dyes can be used, but usable dyes are not limited to these only. Besides, these color developing dyes can be mixed in different combinations.
Flammability and Explosibility
Not classified
Safety
4-Hydroxy-4′-isopropoxydiphenylsulfone (BPSIP), a novel alternative to BPA, is frequently detected in breast milk and the placental barrier system, suggesting that it may be transmitted from mother to offspring and increase the risk of exposure. In a study of the behavioral and neurobiological effects of early-life exposure to BPSIP (0.02, 0.1, and 0.5 mg/kg body weight/day) in mouse offspring, BPSIP exposure induced ASD-like behaviors in male and female pups, including increased anxiety-related behaviors and decreased spatial memory. A clear pattern of decreased social novelty was observed only in female offspring, accompanied by significant changes in antioxidant levels. In addition, decreased protein levels of complex IV (COX IV) in all tested populations suggest a significant impact on mitochondrial function, which may contribute to abnormal energy metabolism in autism. Changes in synaptic proteins, as evidenced by altered levels of synapsin 1 (SYN1) and postsynaptic density protein 95 (PSD95) in the cerebellum and hippocampus, support the idea of synaptic involvement. These findings suggest that BPSIP may induce sex-specific neurotoxic effects involving oxidative stress, energy production, and synaptic plasticity[1].
Synthesis
30.3 g of bis(p-hydroxyphenyl)sulfone, 18.5 g of isopropylbromide, and 22.2 g of potassium carbonate as acid-binding agent were added to 200 ml of dimethylformamide, then stirred for 4 hours at about 120° C. and dimethylformamide was distilled off under reduced pressure. When this was accomplished, chloroform was added to the residue to extract crude 4-hydroxy-4'-isopropoxydiphenylsulfone. Then this crude compound was refined by using a silica gel column chromatography and 15.7 g of 4-hydroxy-4'-isopropoxydiphenylsulfone was obtained in white microfine crystals with a melting point of 129.0°~131.0° C.
References
[1] SHENGNAN ZHANG. Early-Life Exposure to 4-Hydroxy-4’-Isopropoxydiphenylsulfone Induces Behavioral Deficits Associated with Autism Spectrum Disorders in Mice.[J]. Environmental Science and Technology, 2024: 15984-15996. DOI:10.1021/acs.est.4c04760.
4-Hydroxy-4'-isopropoxydiphenylsulfone Preparation Products And Raw materials
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View Lastest Price from 4-Hydroxy-4'-isopropoxydiphenylsulfone manufacturers
- Product
- 4-Hydroxy-4'-isopropoxydiphenylsulfone 95235-30-6
- Price
- US $0.00/KG
- Min. Order
- 0.10000000149011612KG
- Purity
- 98%
- Supply Ability
- 1000KGS
- Release date
- 2025-11-20
- Product
- 4-Hydroxy-4'-isopropoxydiphenylsulfone 95235-30-6
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100mt/year
- Release date
- 2021-07-13
- Product
- 4-Hydroxy-4'-isopropoxydiphenylsulfone 95235-30-6
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-12