ChemicalBook > CAS DataBase List > Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-

Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-

Product Name
Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-
CAS No.
711085-63-1
Chemical Name
Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-
Synonyms
PNU 282987 free base;(R)-4-Chloro-N-(quinuclidin-3-yl)benzamide;4-chloro-N-[(3R)-quinuclidin-3-yl]benzamide;Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-;N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide
CBNumber
CB23268809
Molecular Formula
C14H17ClN2O
Formula Weight
264.75
MOL File
711085-63-1.mol
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Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- Property

Boiling point:
431.5±30.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
solubility 
DMF: 10 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 5 mg/ml
form 
A crystalline solid
pka
13.86±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
P2774
Product name
PNU-282987
Packaging
10MG
Price
$108
Updated
2025/07/31
TCI Chemical
Product number
P2774
Product name
PNU-282987
Packaging
50MG
Price
$323
Updated
2025/07/31
Cayman Chemical
Product number
17424
Product name
PNU 282987
Purity
≥98%
Packaging
5mg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
17424
Product name
PNU 282987
Purity
≥98%
Packaging
10mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
17424
Product name
PNU 282987
Purity
≥98%
Packaging
25mg
Price
$166
Updated
2024/03/01
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Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- Chemical Properties,Usage,Production

Uses

PNU-282987 is a highly selective α7 nicotinic acetylcholine receptor agonist (1,2). PNU-282,987 has been utilized to generate retinal neurons in the absence of retinal injury or exogenous growth factors in rat (1). PNU-282,987 has the potential to reverse vision loss due to neurodegenerative disease or aging.

Definition

ChEBI: N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide is a carbonyl compound and an organohalogen compound.

in vivo

PNU-282987 (free base) (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit[1].
PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner[1].

Animal Model:Rats[1]
Dosage:1, 3 mg/kg
Administration:i.v.
Result:Significantly reversed amphetamine-induced gating deficit.

IC 50

5-HT3 Receptor

storage

Store at RT

Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- Suppliers

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711085-63-1, Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-Related Search:

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE PNU-282987 S enantiomer hydrochloride PNU-282987 (S enantiomer free base)

  • Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-
  • 4-chloro-N-[(3R)-quinuclidin-3-yl]benzamide
  • PNU 282987 free base
  • N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide
  • (R)-4-Chloro-N-(quinuclidin-3-yl)benzamide
  • 711085-63-1