L-Cysteine methyl ester hydrochloride
- Product Name
- L-Cysteine methyl ester hydrochloride
- CAS No.
- 18598-63-5
- Chemical Name
- L-Cysteine methyl ester hydrochloride
- Synonyms
- H-Cys-Ome;Methyl L-Cysteinate Hydrochloride;(R)-Cysteine Methyl Ester Hydrochloride;actiol;l.j.48;zeotin;acdrile;pectite;visclair;M-Cysten
- CBNumber
- CB2327369
- Molecular Formula
- C4H10ClNO2S
- Formula Weight
- 171.65
- MOL File
- 18598-63-5.mol
L-Cysteine methyl ester hydrochloride Property
- Melting point:
- 142 °C (dec.)(lit.)
- alpha
- -2.25 º (c=5, 1 N HCl)
- Density
- 1.232 (estimate)
- FEMA
- 4781 | L-CYSTEINE METHYL ESTER HYDROCHLORIDE
- refractive index
- -2.5 ° (C=20, MeOH)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol, Water (Slightly)
- form
- Crystalline Powder
- color
- White
- biological source
- synthetic
- optical activity
- [α]20/D 1.8°, c = 10 in methanol
- Water Solubility
- Soluble in water
- Merck
- 13,5809
- BRN
- 3685824
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- WHOHXJZQBJXAKL-DFWYDOINSA-N
- CAS DataBase Reference
- 18598-63-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 2
- RTECS
- HA2460000
- F
- 1-10
- HS Code
- 29309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H303May be harmfulif swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 410209
- Product name
- L-Cysteine methyl ester hydrochloride
- Purity
- 98%
- Packaging
- 5g
- Price
- $53.1
- Updated
- 2025/07/31
- Product number
- 410209
- Product name
- L-Cysteine methyl ester hydrochloride
- Purity
- 98%
- Packaging
- 25g
- Price
- $78.1
- Updated
- 2025/07/31
- Product number
- C0577
- Product name
- L-Cysteine Methyl Ester Hydrochloride
- Purity
- >99.0%(T)
- Packaging
- 5g
- Price
- $17
- Updated
- 2023/06/20
- Product number
- C0577
- Product name
- L-Cysteine Methyl Ester Hydrochloride
- Purity
- >99.0%(T)
- Packaging
- 25g
- Price
- $32
- Updated
- 2022/04/27
- Product number
- C0577
- Product name
- L-Cysteine Methyl Ester Hydrochloride
- Purity
- >99.0%(T)
- Packaging
- 500g
- Price
- $273
- Updated
- 2022/04/27
L-Cysteine methyl ester hydrochloride Chemical Properties,Usage,Production
Chemical Properties
white crystalline powder
Uses
A mucolytic. An effective drug for the treatment of liver failure. Shown to effectively inhibit the binding of ethynylestradiol metabolites to protein and nucleic acids.
Uses
Mucolytic agent
Uses
L-Cysteine methyl ester hydrochloride is a biochemical shown to inhibit binding of ethynylestradiol metabolites to protein and nucleic acids. It used in the synthesis of peptides, Preparation of thiazolidine-4-carboxylates with carbonyl compounds.
Definition
ChEBI: Mecysteine hydrochloride is an alpha-amino acid ester.
Preparation
L-Cysteine methyl ester hydrochloride is prepared by esterification of L-cysteine hydrochloride monohydrate with methanol in the presence of hydrogen chloride.
reaction suitability
reaction type: solution phase peptide synthesis
Trade name
Acthiol (Joullié, France), Actiol (Lirca, Italy), Visclair (Sinclair, UK), Aslos-C (Nissin, J), Epectan (Seiko, Japan), Moltanine (Tohok.-Tokyo Tanabe, Japan), Radcol (Nippon Universal, Japan), Sekinin (Tokyo Hosei, Japan).
Synthesis
67-56-1
52-89-1
18598-63-5
3 mL of sulfoxide chloride (SOCl2) was slowly added dropwise to 35 mL of methanol under nitrogen protection in an ice bath. Subsequently, the reaction mixture was stirred at room temperature for 1 hour. After that, 1 g of L-cysteine hydrochloride monohydrate (Cys-HCl-H2O) was added to the above solution in batches. The reaction was continued with the mixed solution at room temperature for 3 hours and then heated to reflux for 1 hour. Upon completion of the reaction, the volatile components and solvent were removed by distillation under reduced pressure, and the resulting residue was recrystallized using a solvent mixture of methanol-dichloromethane (CH3OH-CH2Cl2) to give 0.84 g of the white solid product L-cysteine methyl ester hydrochloride in 85.9% yield. The product was analyzed by infrared spectroscopy (IR, KBr press) showing characteristic absorption peaks: 3040.4 cm-1 (strong, NH2 stretching vibration), 1709.7 cm-1 (strong, C=O stretching vibration), 2580 cm-1 (weak, SH stretching vibration). The nuclear magnetic resonance hydrogen spectrum (1H NMR, D2O as solvent, TMS as internal standard) data were as follows: δ 4.453 (t, 1H, CH, J = 5.2 Hz), 3.871 (s, 3H, CH3), 3.164 (t, 2H, CH2, J = 6.4 Hz). Elemental analysis results: Calculated values (C4H10NO2SCCl): C, 27.99%; H, 5.87%; N, 8.16%. Measured values: C, 28.11%; H, 6.01%; N, 8.08%.
References
[1] European Journal of Medicinal Chemistry, 2014, vol. 74, p. 199 - 215
[2] Journal of Organic Chemistry, 2013, vol. 78, # 9, p. 4270 - 4277
[3] Tetrahedron Asymmetry, 2000, vol. 11, # 21, p. 4255 - 4261
[4] Journal of the American Chemical Society, 2008, vol. 130, # 15, p. 5052 - 5053
[5] European Journal of Medicinal Chemistry, 2012, vol. 55, p. 176 - 187,12
L-Cysteine methyl ester hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from L-Cysteine methyl ester hydrochloride manufacturers
- Product
- L-Cysteine methyl ester hydrochloride 18598-63-5
- Price
- US $1.00-4.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2025-09-04
- Product
- L-Cysteine methyl ester hydrochloride 18598-63-5
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500kgs
- Release date
- 2021-09-26
- Product
- H-L-Cys-OMe.HCl 18598-63-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-24