1-AMINO-1-CYCLOPENTANECARBOXAMIDE
- Product Name
- 1-AMINO-1-CYCLOPENTANECARBOXAMIDE
- CAS No.
- 17193-28-1
- Chemical Name
- 1-AMINO-1-CYCLOPENTANECARBOXAMIDE
- Synonyms
- Irbesartan Impurity 36;1-AMino-cyclopentyl aMide;Carboxamidocyclopentylamine;1-CARBOXAMIDOCYCLOPENTYLAMINE;1-AMINOCYCLOPENTANE CARBOXAMIDE;1-amino-1-cyclopentancarboxamide;Cyclopentanecarboxamide, 1-amino-;1-AMinocyclopentane-1-carboxaMide;1-AMINO-1-CYCLOPENTANECARBOXAMIDE
- CBNumber
- CB2328230
- Molecular Formula
- C6H12N2O
- Formula Weight
- 128.17
- MOL File
- 17193-28-1.mol
1-AMINO-1-CYCLOPENTANECARBOXAMIDE Property
- Melting point:
- 95-96℃ (acetone pentane )
- Boiling point:
- 301.5±21.0 °C(Predicted)
- Density
- 1.132±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 16.14±0.20(Predicted)
- Appearance
- Light yellow to brown Solid
- CAS DataBase Reference
- 17193-28-1(CAS DataBase Reference)
Safety
- Hazard Codes
- T
- Risk Statements
- 22-41-48/25
- Safety Statements
- 22-26-36/39-45
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P314Get medical advice/attention if you feel unwell.
N-Bromosuccinimide Price
- Product number
- A634448
- Product name
- 1-Amino-1-cyclopentanecarboxamide
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FA08267
- Product name
- 1-Amino-1-cyclopentanecarboxamide
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- FA08267
- Product name
- 1-Amino-1-cyclopentanecarboxamide
- Packaging
- 2g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 073114
- Product name
- 1-Amino-1-cyclopentanecarboxamide
- Purity
- 95+%
- Packaging
- 10g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FA08267
- Product name
- 1-Amino-1-cyclopentanecarboxamide
- Packaging
- 5G
- Price
- $100
- Updated
- 2021/12/16
1-AMINO-1-CYCLOPENTANECARBOXAMIDE Chemical Properties,Usage,Production
Uses
1-Amino-1-cyclopentanecarboxamide is a useful synthesis intermediate. An amino-cyclopentanecarboxamide derivative with pharmacological and tumor inhibiting activity.
Synthesis
49830-37-7
17193-28-1
General procedure for the synthesis of cis-2-amino-1-cyclopentanecarboxamide from 1-aminocyclopentanecarbonitrile: 1. Preparation of 3-(1-carbamoyl-1-cyclopentylamino)-1-propanesulfonic acid (Compound OT): NaCN (15.34 g, 0.31 mol) and NH4Cl (19.75 g, 0.37 mol) were added to a 250 mL single-necked flask containing 30% NH4OH (120 mL) under vigorous stirring. The corresponding ketones were added dropwise over 20 min at room temperature. The mixture was stirred at room temperature for 3 days and then extracted with dichloromethane (50 mL). The organic layer was separated and dried with anhydrous sodium sulfate for 2 hours. The sodium sulfate was removed by filtration and the solvent was removed under reduced pressure to give crude aminonitrile. Distillation under reduced pressure gave the target product as a colorless oil (14.03 g, 127 mmol, 51% yield). 2. Aminonitrile (41 mmol) was dissolved in 30 mL of CH2Cl2 and added dropwise to 10 g of concentrated sulfuric acid stirred in an ice-water bath, maintaining the internal temperature at 15 °C. The mixture was then stirred in an ice-water bath. The ice bath was then removed and the mixture was heated to 40 °C for 1 hour. The mixture was cooled in the ice water bath and poured into 200 g of crushed ice. The mixture was adjusted to pH 7-8 with 28% NH3 aqueous solution and extracted with EtOAc (3 x 100 mL). The extract was collected, dried (MgSO4) and evaporated to dryness. The crude solid was recrystallized in EtOAc/Hex to give the target product as a white solid (1.36 g, 10.6 mmol, 27% yield). 3. A solution of 1,3-propanesulfonolactone (1 M, 6.30 mL) in toluene was added to a solution of 2-amino-2-methylpropanamide (0.4350 g, 4.26 mmol) in MTBK (7 mL) and ethanol (0.5 mL). The mixture was heated to reflux for 4 hours and then cooled to room temperature. The solid was collected by filtration and rinsed with acetone (2 x 5 mL). The solid was dried in a vacuum oven at 60 °C for 18 h (0.74 g). The solid was recrystallized in ethanol (5 mL) and water (5 mL). After drying, cis-2-amino-1-cyclopentanecarboxamide was obtained as a fine white solid (0.39 g, 2.80 mmol, 45% yield).
References
[1] Patent: US2006/223855, 2006, A1. Location in patent: Page/Page column 157
1-AMINO-1-CYCLOPENTANECARBOXAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
1-AMINO-1-CYCLOPENTANECARBOXAMIDE Suppliers
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 0512-68780025 18962125825
- sales@ryanchem.com
- Country
- China
- ProdList
- 167
- Advantage
- 62
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 027-8866 0053/88660577/88660578
- Fax
- 027-8899 1911
- Country
- China
- ProdList
- 1073
- Advantage
- 55
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- sales@witofly.com
- Country
- China
- ProdList
- 2864
- Advantage
- 52
- Tel
- 027-27-81302488 15972195220
- Fax
- 027-81302088
- info@dkybpc.com
- Country
- China
- ProdList
- 1758
- Advantage
- 58
View Lastest Price from 1-AMINO-1-CYCLOPENTANECARBOXAMIDE manufacturers
- Product
- 1-Aminocyclopentane-1-carboxamide 17193-28-1
- Price
- US $690.00/g
- Min. Order
- 1g
- Purity
- 97
- Supply Ability
- 500 Kg
- Release date
- 2024-04-11
- Product
- 1-AMINO-1-CYCLOPENTANECARBOXAMIDE 17193-28-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20