3,5-BIS(TRIFLUOROMETHYL)PYRAZOLE

Product Name: 3,5-BIS(TRIFLUOROMETHYL)PYRAZOLE
CAS No.: 14704-41-7
Chemical Name: 3,5-BIS(TRIFLUOROMETHYL)PYRAZOLE
Synonyms: TIMTEC-BB SBB006683;3,5-DI(TRIFLUOROMETHYL)PYRAZOLE;3,3-Bis(trifluoromethyl)pyrazol;3,5-Bis(trfluoromethyl)pyrazole;3,5-Bis(trifluormethyl)pyrazole;3,5-BIS(TRIFLUOROMETHYL)PYRAZOLE;3,5-Di(trifluoromethyl)-1H-pyrazole;3,5-Bis(trifluoromethyl)pyrazole97%;3,5-Bis(trifluoromethyl)pyrazole 97%;3,5-BIS(TRIFLUOROMETHYL)-1H-PYRAZOLE
CBNumber: CB2330080
Molecular Formula: C5H2F6N2
Formula Weight: 204.07
MOL File: 14704-41-7.mol

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3,5-BIS(TRIFLUOROMETHYL)PYRAZOLE Property

Melting point:: 83-85 °C(lit.)
Boiling point:: 147°C(lit.)
Density: 1.5672 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 7.12±0.10(Predicted)
color: White to Almost white
InChI: 1S/C5H2F6N2/c6-4(7,8)2-1-3(13-12-2)5(9,10)11/h1H,(H,12,13)
InChIKey: NGDDUAYSWPUSLX-UHFFFAOYSA-N
SMILES: FC(F)(F)c1cc([nH]n1)C(F)(F)F
CAS DataBase Reference: 14704-41-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933199090
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 390399
Product name: 3,5-Bis(trifluoromethyl)pyrazole
Purity: 99%
Packaging: 1g
Price: $56.5
Updated: 2022/05/15

TCI Chemical

Product number: B4762
Product name: 3,5-Bis(trifluoromethyl)pyrazole
Purity: >98.0%(GC)
Packaging: 1g
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: B4762
Product name: 3,5-Bis(trifluoromethyl)pyrazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $195
Updated: 2025/07/31

TRC

Product number: T790763
Product name: 3,5-Bis(Trifluoromethyl)-1H-pyrazole
Packaging: 500mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-3-35
Product name: 3,5-Bis(trifluoromethyl)pyrazole
Purity: 97%
Packaging: 5G
Price: $77
Updated: 2021/12/16

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3,5-BIS(TRIFLUOROMETHYL)PYRAZOLE Chemical Properties,Usage,Production

Chemical Properties

colorless to light yellow crystalline powder

Synthesis

1522-22-1

14704-41-7

Hexafluoroacetylacetone 1a (29.4 g, 20 mL, 141 mmol) and anhydrous ethanol (100 mL) were added to a 250 mL three-necked, round-bottomed flask fitted with a magnetic stirrer, a thermometer, an aqueous condenser tube and a constant-pressure dropping funnel. The reaction system was cooled to 5 °C in an ice-water bath. Hydrazine monohydrate (7.0 g, 6.8 mL, 140 mmol) was slowly added dropwise over a period of 20 min, controlling the reaction temperature to not exceed 8 °C. After the dropwise addition, the reaction mixture was heated to reflux for 8 hours. After completion of the reaction, it was cooled to room temperature and subsequently concentrated under reduced pressure on a rotary evaporator, controlling the temperature of the water bath not to exceed 40 °C, to give a yellow syrupy product. The product was dissolved in 98% concentrated sulfuric acid (10 mL) under cooling in an ice bath and vigorous stirring.After 15 min, the reaction mixture was carefully decanted into ice (300 g) to precipitate a light yellow solid, which was washed with ice water (50 mL) to afford 3,5-bis(trifluoromethyl)-1H-pyrazole 2 (25.13 g, 88% yield) as a colorless solid with a characteristic odor. The product characterization data were as follows: 1H NMR (DMSO-d6/CDCl3, 2:1): δ= 5.70 (brs, 1H, NH), 7.40 (s, 1H, H-4). 13C NMR: δ= 138.1 (q, 2JC-F = 39 Hz, C-3/C-5), 120.5 (q, 1JC-F = 267 Hz, CF3). 105.2 (s, C-4).19F NMR (DMSO-d6/CDCl3, 2:1): δ= -62.5 (s).IR (cm-1): 3160 (s), 1510, 1595 (s), 1150 (s).GC-MS (tR 6.78 min). Elemental Analysis (C5H2F6N2) Calculated: C, 29.43; N, 13.73. Measured: C, 29.44; N, 13.76. pKa 7.10 [Literature Value 25: 7.5]. Melting point 81°C [Literature Value 25: 83-84°C]. The purity of the sample was determined to be >98% by differential scanning calorimetry (DSC) (scan rate 2.58°C/min; melting point 85.2°C).

References

[1] Journal of Fluorine Chemistry, 2012, vol. 139, p. 53 - 57
[2] Journal of Fluorine Chemistry, 1991, vol. 51, # 2, p. 283 - 289
[3] Journal of Organic Chemistry, 2012, vol. 77, # 1, p. 47 - 56
[4] Helvetica Chimica Acta, 1995, vol. 78, # 4, p. 993 - 1000
[5] Journal of Fluorine Chemistry, 1993, vol. 65, # 1-2, p. 21 - 24

3,5-BIS(TRIFLUOROMETHYL)PYRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-BIS(TRIFLUOROMETHYL)PYRAZOLE Suppliers

Americas 1 Belgium 1 China 95 Europe 1 France 1 Germany 2 India 7 Japan 2 Russia 1 Switzerland 3 United Kingdom 6 United States 18 Global 138

J & K SCIENTIFIC LTD.

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View Lastest Price from 3,5-BIS(TRIFLUOROMETHYL)PYRAZOLE manufacturers

Hubei Lidu New Material Technology Co., Ltd

Product: 3,5-BIS(TRIFLUOROMETHYL)PYRAZOLE 14704-41-7
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 98%
Supply Ability: 20TONS
Release date: 2025-11-04

Shaanxi Didu New Materials Co. Ltd

Product: 3,5-BIS(TRIFLUOROMETHYL)PYRAZOLE 14704-41-7
Price: US $1.50/g
Min. Order: 1g
Purity: 99.0% Min
Supply Ability: 100 Tons
Release date: 2025-09-25

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3,5-BIS(TRIFLUOROMETHYL)PYRAZOLE 14704-41-7
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

14704-41-7, 3,5-BIS(TRIFLUOROMETHYL)PYRAZOLERelated Search:

TIMTEC-BB SBB006683

3,5-DI(TRIFLUOROMETHYL)PYRAZOLE

3,5-BIS(TRIFLUOROMETHYL)PYRAZOLE

3,5-BIS(TRIFLUOROMETHYL)-1H-PYRAZOLE

3,3-Bis(trifluoromethyl)pyrazol

3,5-Bis(trifluoromethyl)pyrazole 97%

3,5-Bis(trifluoromethyl)pyrazole97%

3,5-Di(trifluoromethyl)-1H-pyrazole

3,5-Bis(trfluoromethyl)pyrazole

3,5-Bis(trifluoromethyl)-1H-pyrazole 97%

3,5-Bis(trifluoromethyl)-1H-pyrazole97%

3,5-Bis(trifluormethyl)pyrazole

3,5-Bis(trifluoromethyl)pyrazole &gt

1H-Pyrazole, 3,5-bis(trifluoromethyl)-

14704-41-7

C5H2F6N2

Pyrazoles

Heterocyclic Compounds

Building Blocks

Heterocyclic Building Blocks