ARN-3236
- Product Name
- ARN-3236
- CAS No.
- 1613710-01-2
- Chemical Name
- ARN-3236
- Synonyms
- ARN-3236;ARN-3236, 10 mM in DMSO;ARN-3236; ARN 3236; ARN3236;3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 3-(2,4-dimethoxyphenyl)-4-(3-thienyl)-;3-(2,4-DIMETHOXYPHENYL)-4-(THIOPHEN-3-YL)-1H-PYRROLO[2,3-B]PYRIDINE;inhibit,ARN3236,Salt-inducible Kinase (SIK),ARN-3236,ARN 3236,Inhibitor
- CBNumber
- CB23339851
- Molecular Formula
- C19H16N2O2S
- Formula Weight
- 336.41
- MOL File
- 1613710-01-2.mol
ARN-3236 Property
- Density
- 1.278±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:65.67(Max Conc. mg/mL);195.21(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);5.95(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);89.18(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.59(Max Conc. mM) - form
- A crystalline solid
- pka
- 13.33±0.40(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0079380
- Product name
- ARN-3236
- Purity
- 99.60%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0079380
- Product name
- ARN-3236
- Purity
- 99.60%
- Packaging
- 10mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0079380
- Product name
- ARN-3236
- Purity
- 99.60%
- Packaging
- 2mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- Axon3041
- Product name
- ARN3236
- Purity
- 98%
- Packaging
- 5mg
- Price
- $104.5
- Updated
- 2021/12/16
- Product number
- CS-0079380
- Product name
- ARN-3236
- Purity
- 99.60%
- Packaging
- 50mg
- Price
- $550
- Updated
- 2021/12/16
ARN-3236 Chemical Properties,Usage,Production
Biological Activity
ARN-3236 is an orally active, ATP-competitive, SIK2-selective salt-inducible kinase inhibitor (IC50 = 21.63 nM/SIK1, <1 nM/SIK2, 6.63 nM/SIK3) th at suppresses cellular SIK2 activity (by 58% at 1 μM; SKOv3-SIK2 cells, 48 h) with high selectivity over >456 kinases. ARN-3236 effectively suppresses SIK2-dependent growth of ovarian cancer cultures (IC50 = 0.8-2.6 μM in 10 lines, 72 h) and in murine xenograft models in vivo (30, 60, 100 mg/kg/day p.o.). In addition, ARN-3236 sensitizes ovarian cancer cells to paclitaxel in vitro and in vivo. ARN-3236 completes the SIK1-selective HG-9-91-01 (SIK1/2/3 IC50 = 0.6/6.6/9.6 nM) in probing SIKs-mediated cellular signaling events.
storage
Store at -20°C
ARN-3236 Preparation Products And Raw materials
Raw materials
Preparation Products
ARN-3236 Suppliers
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