MANOOL Property

Melting point:

49-52 °C(lit.)

Boiling point:

150-153 °C(Press: 0.3 Torr)

Density 

0.93±0.1 g/cm3(Predicted)

Flash point:

>230 °F

storage temp. 

4°C, stored under nitroge

solubility 

Benzene (Slightly), Chloroform (Slightly), Methanol (Slightly)

form 

Low-Melting Solid

pka

14.47±0.29(Predicted)

color 

White to Off-White

Specific Gravity

0.97

Odor

Very delicate, woody, dry-sweet, and extremely tenacious odor

LogP

6.790 (est)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

MANOOL Chemical Properties,Usage,Production

Uses

Maintains anti-proliferative activity against human malignant cell strains.

Definition

ChEBI: A labdane diterpenoid in which the labdane skeleton has double bonds at positions 8(17) and 14 and carries an R-hydroxy group at position 13.

Preparation

By extraction of cornrninuted wood of Dacrydium biforme, a tree indigenous to New Zealand, with alcohol or Acetone. The extract is neutralized with alkali, and the crude Manool may be recrystallized.

Cytotoxicity

IC50 (μg/mL): 49.3 (V79), 15.6 (B16F10),17.1 (MCF-7), 6.7 (HeLa), 28.5 (HepG2),9.6 (MO59 J), 6.7 (U343), 13.1 (U251)(de Oliveira et al. 2016)