(R)-5,7-difluorochroman-4-ol
- Product Name
- (R)-5,7-difluorochroman-4-ol
- CAS No.
- 1270294-05-7
- Chemical Name
- (R)-5,7-difluorochroman-4-ol
- Synonyms
- (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol;Tegoprazan Impurity 11;R-5,7-difluorobenzo dihydropyran-4-ol;Tegoprazan side chain;Tegoprazan ImpuritiesC;(R)-5, 7-difluorobenzopyrane-4-ol;2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)-;[2-(2-chlorophenyl)ethanamine, 1-Amino-2-(2-chlorophenyl)ethane, 2-(2-Chlorophenyl)ethylamine]
- CBNumber
- CB23354564
- Molecular Formula
- C9H8F2O2
- Formula Weight
- 186.16
- MOL File
- 1270294-05-7.mol
(R)-5,7-difluorochroman-4-ol Property
- Boiling point:
- 228.4±40.0 °C(Predicted)
- Density
- 1.402±0.06 g/cm3(Predicted)
- pka
- 13.09±0.20(Predicted)
- InChI
- InChI=1S/C9H8F2O2/c10-5-3-6(11)9-7(12)1-2-13-8(9)4-5/h3-4,7,12H,1-2H2/t7-/m1/s1
- InChIKey
- HGTYMLFMXKYIQW-SSDOTTSWSA-N
- SMILES
- C1OC2=CC(F)=CC(F)=C2[C@H](O)C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
(R)-5,7-difluorochroman-4-ol Chemical Properties,Usage,Production
Uses
(R)-5,7-difluorochroman-4-ol is an important intermediate in the synthesis of tegoprazan[1].
Production Methods
Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol, where ketoreductase is one or combination of two or more of short-chain dehydrogenases/reductases family (SDR), medium-chain dehydrogenases/reductase (MDR) or aldo-Keto reductase (AKR)[1].
References
[1]PAN X, et al. "Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate, and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol.", CN202210486605.0. 2022.
(R)-5,7-difluorochroman-4-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-5,7-difluorochroman-4-ol manufacturers
- Product
- (R)-5,7-difluorochroman-4-ol 1270294-05-7
- Price
- US $0.10/kg
- Min. Order
- 0.005kg
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2024-04-15
- Product
- (R)-5,7-difluorochroman-4-ol 1270294-05-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1000KGS
- Release date
- 2023-06-19
- Product
- (R)-5,7-difluorochroman-4-ol 1270294-05-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 99.0%min
- Supply Ability
- 2000kg
- Release date
- 2023-06-09