(R)-5,7-difluorochroman-4-ol

Product Name: (R)-5,7-difluorochroman-4-ol
CAS No.: 1270294-05-7
Chemical Name: (R)-5,7-difluorochroman-4-ol
Synonyms: (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol;Tegoprazan Impurity 11;R-5,7-difluorobenzo dihydropyran-4-ol;Tegoprazan Impurity;Tegoprazan side chain;Tegoprazan ImpuritiesC;Tigora produced impurity 11;(R)-5, 7-difluorobenzopyrane-4-ol;(R)-5,7-Difluorochroman-4-ol ，Tegoprazan intermdiate;2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)-
CBNumber: CB23354564
Molecular Formula: C9H8F2O2
Formula Weight: 186.16
MOL File: 1270294-05-7.mol

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(R)-5,7-difluorochroman-4-ol Property

Boiling point:: 228.4±40.0 °C(Predicted)
Density: 1.402±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: 13.09±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C9H8F2O2/c10-5-3-6(11)9-7(12)1-2-13-8(9)4-5/h3-4,7,12H,1-2H2/t7-/m1/s1
InChIKey: HGTYMLFMXKYIQW-SSDOTTSWSA-N
SMILES: C1OC2=CC(F)=CC(F)=C2[C@H](O)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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(R)-5,7-difluorochroman-4-ol Chemical Properties,Usage,Production

Uses

(R)-5,7-difluorochroman-4-ol is an important intermediate in the synthesis of tegoprazan[1].

Production Methods

Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol, where ketoreductase is one or combination of two or more of short-chain dehydrogenases/reductases family (SDR), medium-chain dehydrogenases/reductase (MDR) or aldo-Keto reductase (AKR)[1].

References

[1]PAN X, et al. "Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate, and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol.", CN202210486605.0. 2022.

(R)-5,7-difluorochroman-4-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-5,7-difluorochroman-4-ol Suppliers

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CE Pharm Co.,Ltd

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View Lastest Price from (R)-5,7-difluorochroman-4-ol manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: (R)-5,7-Difluorochroman-4-OL 1270294-05-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-10-22

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (R)-5,7-difluorochroman-4-ol 1270294-05-7
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-17

Zhengzhou Anbu Chem Co.,Ltd

Product: (R)-5,7-difluorochroman-4-ol 1270294-05-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000KGS
Release date: 2023-06-19

1270294-05-7, (R)-5,7-difluorochroman-4-olRelated Search:

Dimethoxymethane 1-benzyl-2-methyl-1H-imidazole-carbaldehyde 1H-Benzimidazole-6-carboxylic acid, 4-hydroxy-2-methyl-1-(phenylmethyl)-, ethyl ester 5,7-difluorochroman-4-one (Dimethylamino)acetaldehyde Dimethyl Acetal 2-Aminobiphenyl 1-(piperidine-4-carbonyl)piperidine-4-carboxylic acid hydrochloride Butanedioic acid, 2-[[2-methyl-1-(phenylmethyl)-1H-imidazol-5-yl]methylene]-, 1-ethyl ester, (2E)- 1H-Benzimidazole-6-carboxamide, 4-hydroxy-N,N,2-trimethyl-1-(phenylmethyl)- Benzoic acid, 4-[[4-(aminocarbonyl)-1-piperidinyl]methyl]- Revefenacin Impurity 16 1-benzyl-4-hydroxy-2-methyl-1H-benzo[d]imidazole-6-carboxylic acid Dibenzofuran

2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)-

(4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol

R-5,7-difluorobenzo dihydropyran-4-ol

Tegoprazan Impurity 11

[2-(2-chlorophenyl)ethanamine, 1-Amino-2-(2-chlorophenyl)ethane, 2-(2-Chlorophenyl)ethylamine]

(R)-5, 7-difluorobenzopyrane-4-ol

Tegoprazan side chain

Tegoprazan ImpuritiesC

Tegoprazan Impurity

Tigora produced impurity 11

(4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol - [D82158]

(R)-5,7-Difluorochroman-4-ol ，Tegoprazan intermdiate

1270294-05-7

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