(R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione

ChemicalBook > CAS DataBase List > (R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione

(R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione

Product Name: (R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione
CAS No.: 2088771-61-1
Chemical Name: (R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione
Synonyms: Impurity FP-B;Sitagliptin-17;Sitagliptin Impurity 20;Sitagliptin Impurity FP-B;Sitagliptin FP Impurity B;Sitagliptin Triazecine Impurity;(R)-Sitagliptin Tablets EP Impurity FP-B;(R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl);Sitagliptin FP Impurity B/ Sitagliptin Triazecine Analog;(R)-Sitagliptin Tablets EP Impurity FP-B ((R)-Sitagliptin Triazecine Analog)
CBNumber: CB23371367
Molecular Formula: C16H13F6N5O2
Formula Weight: 421.3
MOL File: 2088771-61-1.mol

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(R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione Property

Melting point:: >189°C (dec.)
Density: 1.67±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 12.02±0.40(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1S/C16H13F6N5O2/c17-9-6-11(19)10(18)4-7(9)3-8-5-12(28)23-1-2-27-13(14(29)24-8)25-26-15(27)16(20,21)22/h4,6,8H,1-3,5H2,(H,23,28)(H,24,29)/t8-/m1/s1
InChIKey: CJUCSNDPMOGZTM-MRVPVSSYSA-N
SMILES: N1[C@H](CC2=CC(F)=C(F)C=C2F)CC(=O)NCCN2C(C(F)(F)F)=NN=C2C1=O

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Hazard and Precautionary Statements (GHS)

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(R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione Chemical Properties,Usage,Production

Uses

(10R)-Sitagliptin Triazecine Analog is related to the family of Sitagliptin compounds which has recently been approved for the therapy of type II diabetes.

(R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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2088771-61-1, (R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dioneRelated Search:

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate rac-Sitagliptin EP Impurity B HCl 7-[(3R)-3-[(N-Acetyl)AMino]-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoroMethyl)-1,2,4-triazolo[4,3-a]pyrazine 1,2,4-Triazolo[4,3-a]pyrazine, 7-[3-amino-1-oxo-4-(2,4,5-trifluorophenyl)-2-butenyl]-5,6,7,8-tetrahydro- 3-(trifluoromethyl)- Sitagliptin DeaMino IMpurity 1 Sitagliptin Impurity 1 Sitagliptin Impurity 26 Sitagliptin Impurity 14 Sitagliptin Impurity 28 Sitagliptin N-Phoshate IMpurity Sitagliptin Sitagliptin phosphate Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)- (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one BOC-(S)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID Sitagliptin N-Boc IMpurity Sitagliptin Impurity 35

(R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione

Sitagliptin Impurity FP-B

Impurity FP-B

Sitagliptin Impurity 20

Sitagliptin-17

Sitagliptin FP Impurity B

(R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)

Sitagliptin impurity 6/Sitagliptin FP Impurity B/Sitagliptin Triazecine Analog/10-(2,4,5-Trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro [1,2,4] triazolo [3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione

1,2,4-Triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione, 6,7,10,11-tetrahydro-3-(trifluoromethyl)-10-[(2,4,5-trifluorophenyl)methyl]-, (10R)-

(10R)?- 6,?7,?10,?11-?Tetrahydro-?3-?(trifluoromethyl)?-?10-?[(2,?4,?5-?trifluorophenyl)?methyl]?-1,?2,?4-?triazolo[3,?4-?c]?[1,?4,?7]?triazecine-?8,?12(5H,?9H)?-?dione

Sitagliptin FP Impurity B/ Sitagliptin Triazecine Analog

(R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione? (Sitagliptin Impurity）

Sitagliptin Triazecine Impurity

(R)-Sitagliptin Tablets EP Impurity FP-B ((R)-Sitagliptin Triazecine Analog)

(10R)-3-(trifluoromethyl)-10-[(2,4,5-trifluorophenyl)methyl]-5H,6H,7H,8H,9H,10H,11H,12H-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12-dione

(R)-Sitagliptin Tablets EP Impurity FP-B

2088771-61-1

C16H13F6N5O2