3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

Product Name: 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
CAS No.: 762240-92-6
Chemical Name: 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
Synonyms: Sitagliptin hydrochloride;3-(trifluoromethyl)-5,6,7,8-tetrahydro;Sitagliptin Triazole Hydrochloride;3-(TRIFLUOROMETHYL)-5,6,7,8- TETRAHYDRO[1,2,4]TRIAZOLO[4,3-;3-(Trifluoromethyl)-5;Sitagliptin interMediate A;3-trifluoro Methyl-[1,2,4]triazole[4,3-a]piperazine hydrochloride;3-(Trifluoromethyl)-5 6 7 8-tetrahydro-1 2 4triazolo4 3-apyrazine hydroch;5,6,7,8-Tetrahydro-3-(trifluormethyl)-[4,3-a]-1,2,4-triazolopyrazine hydrochloride;5,6,7,8-Tetrahydro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 98%
CBNumber: CB31228965
Molecular Formula: C6H7F3N4.ClH
Formula Weight: 228.6
MOL File: 762240-92-6.mol

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3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Property

Melting point:: 236-246°C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1S/C6H7F3N4.ClH/c7-6(8,9)5-12-11-4-3-10-1-2-13(4)5;/h10H,1-3H2;1H
InChIKey: AQCSCRYRCRORET-UHFFFAOYSA-N
SMILES: C12=NN=C(C(F)(F)F)N1CCNC2.[H]Cl
CAS DataBase Reference: 762240-92-6(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN2811
HS Code: 2933599577

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T2998
Product name: 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $54
Updated: 2025/07/31

TCI Chemical

Product number: T2998
Product name: 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $158
Updated: 2025/07/31

TRC

Product number: T791810
Product name: 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride
Packaging: 500mg
Price: $65
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-7-Y4
Product name: 5,6,7,8-Tetrahydro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazinehydrochloride
Packaging: 25g
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT44582
Product name: Sitagliptin hydrochloride
Packaging: 250g
Price: $75
Updated: 2021/12/16

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3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Chemical Properties,Usage,Production

Description

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride is a pharmaceutical intermediate compound used in the preparation of Sitagliptin phosphate. Sitagliptin is an oral hypoglycaemic agent, a dipeptidyl peptidase-4 inhibitor, which is used in the treatment of type 2 diabetes.

Chemical Properties

White Solid or White to Light yellow powder to crystal

Uses

Sitagliptin intermediate.

Synthesis

A suspension of N'-[(2Z)-Piperazin-2-ylidene]trifluoroacetohydrazide (27.3 g, 0.13 mol) in 110 mL of methanol was WARMED TO 55 ℃. 37% Hydrochloric acid (11.2 mL, 0.14 mol) was added over 15 min at this temperature. During the addition, all solids dissolved, resulting in a clear solution. The reaction was aged for 30 min. The solution was cooled to 20 ℃ and aged at this temperature until a seed bed formed (10 min to 1 h). 300 ML of MTBE was charged at 20 ℃ over 1 h. The resulting slurry was cooled to 2 ℃, aged for 30 min and filtered. Solids were washed with 50 mL of ethanol: MTBE (1: 3) and dried under vacuum at 45 ℃. Yield of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride was 26.7 g (99.5 area wt% pure by HPLC).

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Suppliers

Canada 1 China 526 India 61 Japan 1 Switzerland 1 United Kingdom 2 United States 26 Global 618

Hunan Furui Biopharma Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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View Lastest Price from 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 762240-92-6
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 97.5%-101.0%
Supply Ability: 10 TONS
Release date: 2021-06-24

Guangzhou Tosun Pharmaceutical Ltd

Product: Sitagliptin Impurity 18 762240-92-6
Price: US $0.00-0.00/mg
Min. Order: 5mg
Purity: 95%+
Supply Ability: 1000mg
Release date: 2025-02-17

S&Y Biochem Co.,Ltd

Product: 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 762240-92-6
Price: US $1.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000
Release date: 2025-02-14

762240-92-6, 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochlorideRelated Search:

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate (+/-)1-(1-Naphthyl)ethylamine Sitagliptin Impurity 27 Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)- Sitagliptin N-Sulfate Sitagliptin Defuoro IMpurity 4 Sitagliptin Impurity 26 Meldrum's Acid Fenasi Sitagliptin phosphate Prazosin 2-Methylpyrazine Terazosin hydrochloride Terazosin Doxazosin Tetramethylpyrazine Sitagliptin Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)-

3-(TRIFLUOROMETHYL)-5,6,7,8- TETRAHYDRO[1,2,4]TRIAZOLO[4,3-

3-trifluoro Methyl-[1,2,4]triazole[4,3-a]piperazine hydrochloride

Sitagliptin Triazole Hydrochloride

Sitagliptin Impurity 64

5,6,7,8-Tetrahydro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 98%

Sitagliptin interMediate A

1,2,4-Triazolo[4,3-a]pyrazine,5,6,7,8-tetrahydro-3-(trifluoroMethyl)-,hydrochloride(1:1)

3 - (three fluorinated Methyl) - 5,6,7,8 - four hydrogen - triazole 4-trichlorobenzene [1] and [4, 3 - alpha] pyrazine hydrochloride

3-(Trifluoromethyl)-5,6,7,8-tetra-hydro-[1,2,4]-Triazolo-[4,3-a]-pyrazine hydrochloride Salt

Sitagliptin side chain

5,6,7,8-Tetrahydro-3-(trifluormethyl)-[4,3-a]-1,2,4-triazolopyrazine hydrochloride

Sitagliptin Intermediates Impurity

3-CF3-5,6,7,8-H4-[1,2,4]triazolo[4,3a]pyrazine HCl

Triazolepine hydrochloride

3-(Trifluoromethyl)-5

3-a]pyrazine hydrochloride

Sitagliptin Impurity 20 HCl

3-(trifluoromethyl)-5,6,7,8-r

Sitagliptin Triazole Impurity HCl

3-(trifluoromethyl)-5,6,7,8-tetrahydro

Sitagliptin-16

3-(Trifluoromethyl)-5 6 7 8-tetrahydro-1 2 4triazolo4 3-apyrazine hydroch

Sitagliptin Triazole (Impurity C)

Sitaglliptin phosphate intermediate

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-α]pyrazine Hydrochloride

5,6,7,8-Tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine Monohydrochloride

5,6,7,8-Tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Monohydrochloride

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochlorid

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

3-(trifluoromethyl)-5,6,7,8-retrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo-[4,3-a]pyrazine HCl

3-(TrifluoroMethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyr

5,6,7,8-Tetrahydro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

3-(trifluoroMethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

5,8-dimethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

Sitagliptin Intermediate 2

1,2,4-Triazolo[4,3-a]pyrazine, 5,6,7,8-tetrahydro-3-(trifluoroMethyl)-, hydrochloride

Sitagliptin hydrochloride

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride （Sitagliptin）

Sitagliptin triazole impurity hydrochloride

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo [4,3-a]pyrazine hydrochloride [TTTP]

pyrazine HCl

Cas762240-92-6 3-trifluoro Methyl-[1,2,4]triazole[4,3-a]piperazine Hydrochloride

Sitagliptin Impurity 20 Hydrochloride

Urgent?

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride ISO 9001：2015 REACH

3-(trifluoromethyl)-5,6,7, 8-tetrahydro-[1,2,4] triazolio [4,3-a] pyrazine

3-(terifluoromethyl)-7-[(2,4,5-trifluorophenyl]acetyl]-5,6,7,8- tetrahydro[1,2,4]triazole[4,3-a]pyrazine

Sitagliptin Triazole HCL

3-trifluoro methyl-[1,2,4]triazole[4,3-a]piperazine hydrochl...

3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-[1,2,4]Triazolo[4,3-A]Pyrazine Hydrochloride / Sitagliptin Intermediate

SitagliptinImpurity20-d4

4-(Trifluoromethyl)-5,6,7,8-tetrahydro [1,2,4] Triazolo[4,3-a]pyrazine Hydrochloride

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride,[1,2,4]Triazolo[4,3-a]Pyrazine Hydrochloride 762240-92-6 Sitagliptin

3-(Trifluoromethyl)-5,6,7,8-tetrahydro- triazolopyrazine Hydrochloride (Triazole)

3-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDRO-[1,2,4]TRIZOLO[4,3-A]PYRAZINE HYDROCHLORIDE

3- (Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2.41 triazolo[4,3-a] pyrazine hydrochloride,TRIAZOLE

3-(trifluoromethyl)-5,6,7, 8-tetrahydro-[1,2,4] triazole and [4,3-a] pyrazine hydrochloride