FLAVOXATE
- Product Name
- FLAVOXATE
- CAS No.
- 15301-69-6
- Chemical Name
- FLAVOXATE
- Synonyms
- Uronid;Bladuril;FLAVOXATE;Flavoxate-d5;DW61 free base;FLAVOXATE USP/EP/BP;Rec-7-0040 free base;Piperidinoethyl 3-methyl-2-phenyl-4-oxo-4H-1-benzopyran-8-carboxylate;2-Piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate;2-(1-Piperidinyl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate
- CBNumber
- CB2341499
- Molecular Formula
- C24H25NO4
- Formula Weight
- 391.46
- MOL File
- 15301-69-6.mol
FLAVOXATE Property
- Melting point:
- 87-88 °C
- Boiling point:
- 564.1±50.0 °C(Predicted)
- Density
- 1.203±0.06 g/cm3(Predicted)
- pka
- 7.3(at 25℃)
- form
- Off-white solid.
- InChI
- InChI=1S/C24H25NO4/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25/h2,4-5,8-12H,3,6-7,13-16H2,1H3
- InChIKey
- SPIUTQOUKAMGCX-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=CC=C2)OC2=C(C(OCCN3CCCCC3)=O)C=CC=C2C(=O)C=1C
- CAS DataBase Reference
- 15301-69-6(CAS DataBase Reference)
Safety
- Toxicity
- LD50 in rats (mg/kg): 1110 orally; 20.8 i.v. (Setnikar, 1975)
N-Bromosuccinimide Price
- Product number
- BF164464
- Product name
- Flavoxate
- Packaging
- 50mg
- Price
- $43
- Updated
- 2021/12/16
- Product number
- BF164464
- Product name
- Flavoxate
- Packaging
- 250mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- E125
- Product name
- Flavoxate
- Packaging
- 50mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- E125
- Product name
- Flavoxate
- Packaging
- 250mg
- Price
- $191
- Updated
- 2021/12/16
- Product number
- RDL0006835
- Product name
- FLAVOXATE-D5
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.15
- Updated
- 2021/12/16
FLAVOXATE Chemical Properties,Usage,Production
Chemical Properties
Flavoxate is also known as urology. Crystallized from ethanol/ether. Its hydrochloride is a white or creamy white crystalline powder. Crystallized from ethanol/ether. Melting point 232～234℃. Soluble in water, methanol, ethanol, chloroform, insoluble in acetone, ether.
Originator
Urispas,SKF,US,1971
Uses
Flavoxate is a pharmaceutical active-containing film delivery device for oral transmucosal administration.
Uses
Relaxant (smooth muscle).
Definition
ChEBI: A carboxylic ester resulting from the formal condensation of 3-methylflavone-8-carboxylic acid with 2-(1-piperidinyl)ethanol.
Manufacturing Process
A mixture of 13.3 grams of anhydrous aluminum chloride and 100 ml of
carbon disulfide is added to 19.4 grams of 2-propionyloxybenzoic acid
(prepared from the reaction of propionyl chloride and 2-hydroxybenzoic acid).
After an initial evolution of hydrogen chloride, the solvent is removed by
distillation and the mixture is heated at 150° to 160°C for 4 hours. The cooled
reaction mixture is treated with ice and hydrochloric acid and the product, 2-
hydroxy-3-carboxypropiophenone, is obtained from the oily residue by
distillation in vacuo.
A mixture of 1.9 grams of 2-hydroxy-3-carboxypropiophenone, 5.0 grams of
sodium benzoate and 20.0 grams of benzoic anhydride is heated at 180° to
190°C for 6 hours. A solution of 15.0 grams of potassium hydroxide in 50 ml
of ethanol and 20 ml of water is added and refluxed for 1 hour. The mixture is
evaporated and the residue after addition of water yields 3-methylflavone-8-
carboxylic acid.
To a suspension of 12.0 grams of 3-methylflavone-8-carboxylic acid in 200 ml
of anhydrous benzene is added 10.0 grams of thionyl chloride. The mixture is
refluxed for 2 hours during which the suspended solid goes into solution. The
solvent is completely removed by distillation, the residue extracted with
benzene and the extract evaporated to dryness. The product, 3-
methylflavone-8-carboxylic acid chloride, is recrystallized from ligroin to give
crystals melting at 155° to 156°C.
To 11.0 grams of 3-methylflavone-8-carboxylic acid chloride dissolved in 150
ml of anhydrous benzene is added at room temperature 4.8 grams of
piperidinoethanol and the mixture refluxed for 2 to 3 hours. The separated
solid is filtered, washed with benzene and dried. The product, piperidinoethyl
3-methylflavone-8-carboxylate hydrochloride is obtained as a colorless
crystalline solid, MP 232° to 234°C, (from US Patent 2,921,070).
brand name
Urispas (Ortho-McNeil).
Therapeutic Function
Spasmolytic
FLAVOXATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from FLAVOXATE manufacturers
- Product
- Flavoxate 15301-69-6
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08