FLAVOXATE

Product Name: FLAVOXATE
CAS No.: 15301-69-6
Chemical Name: FLAVOXATE
Synonyms: Uronid;Bladuril;FLAVOXATE;Flavoxate-d5;DW61 free base;FLAVOXATE USP/EP/BP;Rec-7-0040 free base;Piperidinoethyl 3-methyl-2-phenyl-4-oxo-4H-1-benzopyran-8-carboxylate;2-Piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate;2-(1-Piperidinyl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate
CBNumber: CB2341499
Molecular Formula: C24H25NO4
Formula Weight: 391.46
MOL File: 15301-69-6.mol

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FLAVOXATE Property

Melting point:: 87-88 °C
Boiling point:: 564.1±50.0 °C(Predicted)
Density: 1.203±0.06 g/cm3(Predicted)
pka: 7.3(at 25℃)
form: Off-white solid.
CAS DataBase Reference: 15301-69-6(CAS DataBase Reference)

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Safety

Toxicity: LD50 in rats (mg/kg): 1110 orally; 20.8 i.v. (Setnikar, 1975)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: BF164464
Product name: Flavoxate
Packaging: 50mg
Price: $43
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BF164464
Product name: Flavoxate
Packaging: 250mg
Price: $105
Updated: 2021/12/16

AK Scientific

Product number: E125
Product name: Flavoxate
Packaging: 50mg
Price: $108
Updated: 2021/12/16

AK Scientific

Product number: E125
Product name: Flavoxate
Packaging: 250mg
Price: $191
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0006835
Product name: FLAVOXATE-D5
Purity: 95.00%
Packaging: 5MG
Price: $502.15
Updated: 2021/12/16

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FLAVOXATE Chemical Properties,Usage,Production

Originator

Urispas,SKF,US,1971

Uses

Flavoxate is a pharmaceutical active-containing film delivery device for oral transmucosal administration.

Uses

Relaxant (smooth muscle).

Definition

ChEBI: A carboxylic ester resulting from the formal condensation of 3-methylflavone-8-carboxylic acid with 2-(1-piperidinyl)ethanol.

Manufacturing Process

A mixture of 13.3 grams of anhydrous aluminum chloride and 100 ml of carbon disulfide is added to 19.4 grams of 2-propionyloxybenzoic acid (prepared from the reaction of propionyl chloride and 2-hydroxybenzoic acid). After an initial evolution of hydrogen chloride, the solvent is removed by distillation and the mixture is heated at 150° to 160°C for 4 hours. The cooled reaction mixture is treated with ice and hydrochloric acid and the product, 2- hydroxy-3-carboxypropiophenone, is obtained from the oily residue by distillation in vacuo.
A mixture of 1.9 grams of 2-hydroxy-3-carboxypropiophenone, 5.0 grams of sodium benzoate and 20.0 grams of benzoic anhydride is heated at 180° to 190°C for 6 hours. A solution of 15.0 grams of potassium hydroxide in 50 ml of ethanol and 20 ml of water is added and refluxed for 1 hour. The mixture is evaporated and the residue after addition of water yields 3-methylflavone-8- carboxylic acid.
To a suspension of 12.0 grams of 3-methylflavone-8-carboxylic acid in 200 ml of anhydrous benzene is added 10.0 grams of thionyl chloride. The mixture is refluxed for 2 hours during which the suspended solid goes into solution. The solvent is completely removed by distillation, the residue extracted with benzene and the extract evaporated to dryness. The product, 3- methylflavone-8-carboxylic acid chloride, is recrystallized from ligroin to give crystals melting at 155° to 156°C.
To 11.0 grams of 3-methylflavone-8-carboxylic acid chloride dissolved in 150 ml of anhydrous benzene is added at room temperature 4.8 grams of piperidinoethanol and the mixture refluxed for 2 to 3 hours. The separated solid is filtered, washed with benzene and dried. The product, piperidinoethyl 3-methylflavone-8-carboxylate hydrochloride is obtained as a colorless crystalline solid, MP 232° to 234°C, (from US Patent 2,921,070).

brand name

Urispas (Ortho-McNeil).

Therapeutic Function

Spasmolytic

FLAVOXATE Preparation Products And Raw materials

Raw materials

Preparation Products

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FLAVOXATE Suppliers

China 43 Europe 2 Germany 1 India 6 United Kingdom 4 United States 20 Global 76

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View Lastest Price from FLAVOXATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Flavoxate 15301-69-6
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-08

15301-69-6, FLAVOXATERelated Search:

Vincamine SAFFLOWER YELLOW L-Glutamine Pentoxifylline Aristoforin Tizanidine FLAVOXATE HYDROCHLORIDE (FAD) Flavoxate impurity B Flavoxate impurity A FLAVOXATE HCL,FLAVOXATE HYDROCHLORIDE Terflavoxate FLAVOXATE 3-Quinuclidinyl 3-methylflavone-8-carboxylate hydrochloride 4H-1-Benzopyran-8-carboxylic acid, 3-methyl-4-oxo-2-phenyl-, 2-(1-pipe ridinyl)cyclohexyl ester, hydrochloride, trans-(+-)-

FLAVOXATE

2-(1-Piperidinyl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate

2-Piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate

4H-1-Benzopyran-8-carboxylic acid, 3-methyl-4-oxo-2-phenyl-, 2-(1-piperidinyl)ethyl ester

3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 2-piperidinoethyl ester

Piperidinoethyl 3-methyl-2-phenyl-4-oxo-4H-1-benzopyran-8-carboxylate

2-(Piperidin-1-yl)ethyl 3-Methyl-4-oxo-2-phenyl-4H-chroMene-8-carboxylate

Flavoxate-d5

FLAVOXATE USP/EP/BP

Bladuril

Uronid

DW61 free base

Rec-7-0040 free base

15301-69-6

110153-71-2

C24H25NO4