6-Methylnicotinic acid
- Product Name
- 6-Methylnicotinic acid
- CAS No.
- 3222-47-7
- Chemical Name
- 6-Methylnicotinic acid
- Synonyms
- 6-METHYLNICOTINIC ACID;6-Methylnicotinic;TIMTEC-BB SBB006666;RARECHEM AL BO 0418;6-METHYLINDAN-1-ONE;6-Methylnicotic acid;Niacin EP Impurity A;Etoricoxib Impurity 51;Nicotinic EP Impurity A;6-MethylnicotinicAcid>
- CBNumber
- CB2346883
- Molecular Formula
- C7H7NO2
- Formula Weight
- 137.14
- MOL File
- 3222-47-7.mol
6-Methylnicotinic acid Property
- Melting point:
- 210-213 °C (lit.)
- Boiling point:
- 251.96°C (rough estimate)
- Density
- 1.2528 (rough estimate)
- refractive index
- 1.5030 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Powder, Crystals and/or Chunks
- pka
- 2.37±0.10(Predicted)
- color
- White to light yellow to beige
- Water Solubility
- Sparingly soluble in water.
- BRN
- 112049
- InChI
- InChI=1S/C7H7NO2/c1-5-2-3-6(4-8-5)7(9)10/h2-4H,1H3,(H,9,10)
- InChIKey
- RZOKQIPOABEQAM-UHFFFAOYSA-N
- SMILES
- C1=NC(C)=CC=C1C(O)=O
- CAS DataBase Reference
- 3222-47-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 1430815
- Product name
- 6-Methylnicotinic acid
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 50mg
- Price
- $1320
- Updated
- 2025/07/31
- Product number
- 284750
- Product name
- 6-Methylpyridine-3-carboxylic acid
- Purity
- 99%
- Packaging
- 1g
- Price
- $24.2
- Updated
- 2023/06/20
- Product number
- M1894
- Product name
- 6-Methylnicotinic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $80
- Updated
- 2025/07/31
- Product number
- M1894
- Product name
- 6-Methylnicotinic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $318
- Updated
- 2025/07/31
- Product number
- 284750
- Product name
- 6-Methylpyridine-3-carboxylic acid
- Purity
- 99%
- Packaging
- 5g
- Price
- $110
- Updated
- 2023/06/20
6-Methylnicotinic acid Chemical Properties,Usage,Production
Description
6-Methylnicotinic acid is a biochemical reagent that can be used as a pharmaceutical intermediate or raw material for organic synthesis. 6-Methylnicotinic acid is used as the starting material and 6-methylnicotine can be synthesized through four steps of esterification, condensation, ring-opening rearrangement, and reduction. As an alkaloid, 6-methylnicotine has similarities with nicotine, but slight changes in its molecular structure may lead to differences in its pharmacological effects and addictiveness. It may be used in products such as electronic cigarettes as a substitute or supplement for nicotine.
Chemical Properties
6-Methylnicotinic acid is a white to light yellow to light orange powder to crystals with a melting point of 210 °C. Store under inert gas at room temperature.
Uses
6-Methylnicotinic acid is an intermediate of the drug etoricoxib (a non- steroidal anti-inflammatory drug for the treatment of arthritis and osteoarthritis). It is also used as organic intermediates.
Uses
A degradation product of Nicotinic acid (N429250). An impurity of Nicotinic acid.
General Description
The co-ordination complex of the formula [Ni(L1)2(H2O)4].4H2O where L1H = 6-methylpyridine-3-carboxylic acid was structurally charaterized using X-ray single crystal analysis.
Synthesis
6-Methylnicotinic acid is prepared by selective oxidation of 2-methyl-5-alkylpyridine, wherein the alkyl group has 2 to 8 carbon atoms, using nitric acid at a concentration of 70 to 100 weight percent HNO3, wherein 6 to 15 moles of NHO3 are used per mole of pyridine, and the reaction is carried out at a temperature range of 250 to 325*F. The reaction time is 10 to 60 minutes, and superatmospheric pressure is used to effectively maintain the reactants in the liquid phase, and 6-methylnicotinic acid is recovered from the resulting reaction mixture.
6-Methylnicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Methylnicotinic acid manufacturers
- Product
- 6-Methylnicotinic acid 3222-47-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.0%min
- Supply Ability
- 10tons/month
- Release date
- 2023-06-14
- Product
- 6-Methylpyridine-3-carboxylic acid 3222-47-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
- Product
- 6-Methylpyridine-3-carboxylic acid 3222-47-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10