1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone
- Product Name
- 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone
- CAS No.
- 221615-72-1
- Chemical Name
- 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone
- Synonyms
- Etoricoxib Intermediate 1;1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone;1-(6-Methyl-3-pyridinyl)-2-[4-(Methylthio)phenyl]-ethanone;1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethan-1-one;1-(6-Methyl-3-pyridinyl)-2-[4-(methylsulfanyl)phenyl]ethanone;1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone;Ethanone, 1-?(6-?methyl-?3-?pyridinyl)?-?2-?[4-?(methylthio)?phenyl]?-;Etoricoxib impurity 14/1-(6-Methylpyridin-3-yl)-2-[4-(methylthio)phenyl]ethanone
- CBNumber
- CB52658404
- Molecular Formula
- C15H15NOS
- Formula Weight
- 257.35
- MOL File
- 221615-72-1.mol
1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone Property
- Melting point:
- 111-113℃
- Boiling point:
- 426.7±40.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 3.84±0.10(Predicted)
- Appearance
- Light yellow to green yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5783CR
- Product name
- 1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethanone
- Packaging
- 250mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- A130187
- Product name
- 1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethanone
- Purity
- 97%
- Packaging
- 250mg
- Price
- $30
- Updated
- 2021/12/16
- Product number
- A130187
- Product name
- 1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethanone
- Purity
- 97%
- Packaging
- 1g
- Price
- $59
- Updated
- 2021/12/16
- Product number
- AA00BEXJ
- Product name
- 1-(6-Methylpyridin-3-yl)-2-[4-(methylthio)phenyl]ethanone
- Purity
- 95%
- Packaging
- 250mg
- Price
- $149
- Updated
- 2021/12/16
- Product number
- CM133002
- Product name
- 1-(6-methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethan-1-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $262
- Updated
- 2021/12/16
1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone Chemical Properties,Usage,Production
Uses
1-(6-Methyl-3-pyridinyl)-2-[4-(methylthio)phenyl]ethanone CAS: 221615-72-1 is a useful research compound.
Synthesis
5470-70-2
16188-55-9
221615-72-1
General procedure for the synthesis of 1-(6-methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethanone from 6-methylnicotinic acid methyl ester and 4-methylthiobenzeneacetic acid: 11 g of 4-methylthiobenzeneacetic acid and 200 mL of anhydrous THF were added to a reaction flask and the mixture was heated to 65-70 °C. While maintaining the temperature at 65-70 °C, 175 mL of a 1.0 M t-BuMgCl solution of THF and 5.7 g of 6-methylnicotinic acid methyl ester dissolved in 50 mL of THF were slowly added dropwise. After the dropwise addition was completed, the reaction was continued with stirring at 65-70°C for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and 50 mL of 4 M hydrochloric acid was added slowly and dropwise to quench the reaction. The organic and aqueous layers were separated and the aqueous layer was extracted with 50mL of 4M hydrochloric acid. The aqueous layer was combined, 50g of sodium hydroxide was added and the reaction was heated to 40-50°C for 3 hours. After cooling to room temperature, filtration gave 6.9 g of light yellow solid product in 72.0% yield and 97.3% purity.
References
[1] Patent: CN104045596, 2017, B. Location in patent: Paragraph 0040-0042
1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone manufacturers
- Product
- 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone 221615-72-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone 221615-72-1
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-07-25