ChemicalBook > CAS DataBase List > 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone
1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone
- Product Name
- 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone
- CAS No.
- 221615-72-1
- Chemical Name
- 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone
- Synonyms
- Etoricoxib Intermediate 1;1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone;1-(6-Methyl-3-pyridinyl)-2-[4-(Methylthio)phenyl]-ethanone;1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethan-1-one;1-(6-Methyl-3-pyridinyl)-2-[4-(methylsulfanyl)phenyl]ethanone;1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone;Ethanone, 1-?(6-?methyl-?3-?pyridinyl)?-?2-?[4-?(methylthio)?phenyl]?-;Etoricoxib impurity 14/1-(6-Methylpyridin-3-yl)-2-[4-(methylthio)phenyl]ethanone
- CBNumber
- CB52658404
- Molecular Formula
- C15H15NOS
- Formula Weight
- 257.35
- MOL File
- 221615-72-1.mol
More
Less
1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone Property
- Melting point:
- 111-113℃
- Boiling point:
- 426.7±40.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 3.84±0.10(Predicted)
- Appearance
- Light yellow to green yellow Solid
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
AK Scientific
- Product number
- 5783CR
- Product name
- 1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethanone
- Packaging
- 250mg
- Price
- $104
- Updated
- 2021/12/16
aablocks
- Product number
- AA00BEXJ
- Product name
- 1-(6-Methylpyridin-3-yl)-2-[4-(methylthio)phenyl]ethanone
- Purity
- 95%
- Packaging
- 250mg
- Price
- $149
- Updated
- 2021/12/16
Chemenu
- Product number
- CM133002
- Product name
- 1-(6-methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethan-1-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $262
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11163655
- Product name
- 1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethanone
- Purity
- 97%
- Packaging
- 1g
- Price
- $277
- Updated
- 2021/12/16
Alichem
- Product number
- 221615721
- Product name
- 1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethanone
- Packaging
- 1g
- Price
- $282.8
- Updated
- 2021/12/16
More
Less
1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone Chemical Properties,Usage,Production
Uses
1-(6-Methyl-3-pyridinyl)-2-[4-(methylthio)phenyl]ethanone CAS: 221615-72-1 is a useful research compound.
Synthesis
5470-70-2
16188-55-9
221615-72-1
General procedure for the synthesis of 1-(6-methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethanone from 6-methylnicotinic acid methyl ester and 4-methylthiobenzeneacetic acid: 11 g of 4-methylthiobenzeneacetic acid and 200 mL of anhydrous THF were added to a reaction flask and the mixture was heated to 65-70 °C. While maintaining the temperature at 65-70 °C, 175 mL of a 1.0 M t-BuMgCl solution of THF and 5.7 g of 6-methylnicotinic acid methyl ester dissolved in 50 mL of THF were slowly added dropwise. After the dropwise addition was completed, the reaction was continued with stirring at 65-70°C for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and 50 mL of 4 M hydrochloric acid was added slowly and dropwise to quench the reaction. The organic and aqueous layers were separated and the aqueous layer was extracted with 50mL of 4M hydrochloric acid. The aqueous layer was combined, 50g of sodium hydroxide was added and the reaction was heated to 40-50°C for 3 hours. After cooling to room temperature, filtration gave 6.9 g of light yellow solid product in 72.0% yield and 97.3% purity.
References
[1] Patent: CN104045596, 2017, B. Location in patent: Paragraph 0040-0042
1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone Suppliers
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16075
- Advantage
- 64
- Tel
- 17722620669
- Fax
- 0752-5319394
- liangcong.yi@rafflespt.com
- Country
- China
- ProdList
- 279
- Advantage
- 58
- Tel
- 21-33585366 13311639313
- Fax
- +86-21-34979012
- sales@shyrchem.com
- Country
- China
- ProdList
- 806
- Advantage
- 55
- Tel
- +86-21-38682181 15900741819
- Fax
- +86-21-38682181
- Country
- China
- ProdList
- 282
- Advantage
- 55
- Tel
- 021-68367562 15002147577;
- Fax
- 021-68369562
- sales@haoyunchem.com
- Country
- China
- ProdList
- 457
- Advantage
- 55
- Tel
- 0512-56316828 4008675858
- Fax
- +86-512-56316826
- sales@amateksci.com
- Country
- China
- ProdList
- 9874
- Advantage
- 55
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10263
- Advantage
- 55
- Tel
- 021-64609169 18901607656
- Fax
- 021-64609160
- greensnown@163.com
- Country
- China
- ProdList
- 9906
- Advantage
- 50
- Tel
- 021-50211651 13651607026
- Fax
- +86-21-50211651
- sales@xxgmpharm.com
- Country
- China
- ProdList
- 490
- Advantage
- 58
- Tel
- 021-58892003
- info@qiaochem.com
- Country
- China
- ProdList
- 6059
- Advantage
- 65
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 17305617782
- Fax
- 86-21-50322176
- sales1@rcc.net.cn
- Country
- China
- ProdList
- 208
- Advantage
- 55
- Tel
- 0-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 12475
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 027-50664929, 13971561712
- Fax
- 027-50664927 / QQ: 3452835437
- hubxys2001@163.com
- Country
- China
- ProdList
- 1437
- Advantage
- 55
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28785
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17987
- Advantage
- 58
- Tel
- 021-37199966 13681836088
- Fax
- 021-37597788
- bj@bj-chem.com
- Country
- China
- ProdList
- 463
- Advantage
- 58
- Tel
- 15711964658
- sales@fungsunchem.cn
- Country
- China
- ProdList
- 104
- Advantage
- 58
- Tel
- 0531-88987162 18615427082
- 2823799053@qq.com
- Country
- China
- ProdList
- 544
- Advantage
- 58
- Tel
- +862156762820 +86-13564624040
- sales@myuchem.com
- Country
- China
- ProdList
- 8460
- Advantage
- 58
- Tel
- +86-0571-88938639 +8617705817739
- Fax
- +86-571-88938652，+86-571- 88492614
- info@dycnchem.com
- Country
- China
- ProdList
- 52846
- Advantage
- 58
- Tel
- +86-0571-85134551
- Fax
- 008657185134895
- sales@afinechem.com
- Country
- China
- ProdList
- 15109
- Advantage
- 58
- Tel
- +8617735180244
- mike_yan@xuanranglobal.com
- Country
- CHINA
- ProdList
- 4017
- Advantage
- 58
- Tel
- 020-36607679 19925672674
- Fax
- QQ 3008233717
- 3008233746@qq.com
- Country
- China
- ProdList
- 9883
- Advantage
- 12
- Tel
- 0531-0531-69900633 19963472814
- changyuan20@163.com
- Country
- China
- ProdList
- 2742
- Advantage
- 58
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- chemwill_asia@126.com
- Country
- CHINA
- ProdList
- 23912
- Advantage
- 58
- Tel
- +86 17788583750
- Fax
- +86 571 85220831
- sales@cyanochem.com
- Country
- CHINA
- ProdList
- 281
- Advantage
- 58
- Tel
- 0513-82104991 18912868361
- Fax
- QQ1907456386
- sales11@btcpharm.com
- Country
- China
- ProdList
- 1250
- Advantage
- 58
- Tel
- 2710913286@.com
- 1513643261@qq.com
- Country
- China
- ProdList
- 14246
- Advantage
- 58
- Tel
- 021-021-13773155751 19975051755
- 260924549@qq.com
- Country
- China
- ProdList
- 10524
- Advantage
- 58
- Tel
- +86-023-6139-8061 +86-86-13650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39927
- Advantage
- 58
- Tel
- 0755-61348847 17820674378
- Fax
- 0755-21016893
- 2682116078@qq.com
- Country
- China
- ProdList
- 7843
- Advantage
- 58
- Tel
- 400-820-6829
- sales@mitachieve.com
- Country
- China
- ProdList
- 8860
- Advantage
- 58
- Tel
- 0531-88723173 18596073690
- 1047208234@qq.com
- Country
- China
- ProdList
- 6779
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44894
- Advantage
- 58
- Tel
- 025-57885806 18951785526
- 3075076875@qq.com
- Country
- China
- ProdList
- 29
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44119
- Advantage
- 58
- Tel
- 027-027-59223025 15107168801
- Fax
- 027-59223025
- 1718480011@qq.com
- Country
- China
- ProdList
- 9719
- Advantage
- 58
- Tel
- 027-027-59210159 15377098680
- Fax
- 027-59210159
- 1148280011@qq.com
- Country
- China
- ProdList
- 9835
- Advantage
- 58
- Tel
- 0517-83187139 18205232085
- cai@jiamu-bio.com
- Country
- China
- ProdList
- 2990
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- +86-0755-66853366 +86-13670046396
- export03@qcsrm.com
- Country
- China
- ProdList
- 24342
- Advantage
- 58
- Tel
- 18576690171
- 3001025734@qq.com
- Country
- China
- ProdList
- 8880
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39653
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 15652467323
- sales@inno-chem.com.cn
- Country
- China
- ProdList
- 8293
- Advantage
- 58
- Tel
- 13268215580
- scinova_sales@163.com
- Country
- China
- ProdList
- 7025
- Advantage
- 58
More
Less
View Lastest Price from 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone 221615-72-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
Career Henan Chemical Co
- Product
- 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone 221615-72-1
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-07-25
221615-72-1, 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanoneRelated Search:
2-CHLORO-1,3-DIMETHYLAMINO TRIMETHINIUM HEXAFLUOROPHOSPHATE
P-(METHYLTHIO)PHENYLACETONITRILE
6'-DesMethyl-6'-carboxy Etoricoxib
3-amino-2-chloroacrolein
5-Chloro-6'-Methyl-3-[4-(Methylsulfonyl)phenyl]-2,3'-bipyridine 1'-Oxide
4-methylsulfinylbenzoate
4-Methylsulphonylacetophenone
Etoricoxib Impurity 11
4-Methylthiophenylacetic acid
Etoricoxib Impurity 13
Etoricoxib Impurity 8
4-(methylsulfinyl)benzeneacetic acid
Etoricoxib impurity Q
2-Chloro-1,3-bis(dimentylamino)trimethinium hexafluorophosphate
6-Methylpyridine-3-carboxylic acid
Etoricoxib Impurity M
Etoricoxib Impurity 39
Etoricoxib Impurity 7