1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone

Product Name: 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone
CAS No.: 221615-72-1
Chemical Name: 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone
Synonyms: Etoricoxib Intermediate 1;1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone;1-(6-Methyl-3-pyridinyl)-2-[4-(Methylthio)phenyl]-ethanone;1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethan-1-one;1-(6-Methyl-3-pyridinyl)-2-[4-(methylsulfanyl)phenyl]ethanone;1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone;Ethanone, 1-?(6-?methyl-?3-?pyridinyl)?-?2-?[4-?(methylthio)?phenyl]?-;Etoricoxib impurity 14/1-(6-Methylpyridin-3-yl)-2-[4-(methylthio)phenyl]ethanone
CBNumber: CB52658404
Molecular Formula: C15H15NOS
Formula Weight: 257.35
MOL File: 221615-72-1.mol

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1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone Property

Melting point:: 111-113℃
Boiling point:: 426.7±40.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 3.84±0.10(Predicted)
Appearance: Light yellow to green yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 5783CR
Product name: 1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethanone
Packaging: 250mg
Price: $104
Updated: 2021/12/16

aablocks

Product number: AA00BEXJ
Product name: 1-(6-Methylpyridin-3-yl)-2-[4-(methylthio)phenyl]ethanone
Purity: 95%
Packaging: 250mg
Price: $149
Updated: 2021/12/16

Chemenu

Product number: CM133002
Product name: 1-(6-methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethan-1-one
Purity: 95+%
Packaging: 1g
Price: $262
Updated: 2021/12/16

Crysdot

Product number: CD11163655
Product name: 1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethanone
Purity: 97%
Packaging: 1g
Price: $277
Updated: 2021/12/16

Alichem

Product number: 221615721
Product name: 1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethanone
Packaging: 1g
Price: $282.8
Updated: 2021/12/16

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1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone Chemical Properties,Usage,Production

Uses

1-(6-Methyl-3-pyridinyl)-2-[4-(methylthio)phenyl]ethanone CAS: 221615-72-1 is a useful research compound.

Synthesis

5470-70-2

16188-55-9

221615-72-1

General procedure for the synthesis of 1-(6-methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethanone from 6-methylnicotinic acid methyl ester and 4-methylthiobenzeneacetic acid: 11 g of 4-methylthiobenzeneacetic acid and 200 mL of anhydrous THF were added to a reaction flask and the mixture was heated to 65-70 °C. While maintaining the temperature at 65-70 °C, 175 mL of a 1.0 M t-BuMgCl solution of THF and 5.7 g of 6-methylnicotinic acid methyl ester dissolved in 50 mL of THF were slowly added dropwise. After the dropwise addition was completed, the reaction was continued with stirring at 65-70°C for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and 50 mL of 4 M hydrochloric acid was added slowly and dropwise to quench the reaction. The organic and aqueous layers were separated and the aqueous layer was extracted with 50mL of 4M hydrochloric acid. The aqueous layer was combined, 50g of sodium hydroxide was added and the reaction was heated to 40-50°C for 3 hours. After cooling to room temperature, filtration gave 6.9 g of light yellow solid product in 72.0% yield and 97.3% purity.

References

[1] Patent: CN104045596, 2017, B. Location in patent: Paragraph 0040-0042

1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone Suppliers

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View Lastest Price from 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone 221615-72-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Career Henan Chemical Co

Product: 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone 221615-72-1
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2018-07-25

221615-72-1, 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanoneRelated Search:

2-CHLORO-1,3-DIMETHYLAMINO TRIMETHINIUM HEXAFLUOROPHOSPHATE P-(METHYLTHIO)PHENYLACETONITRILE 6'-DesMethyl-6'-carboxy Etoricoxib 3-amino-2-chloroacrolein 5-Chloro-6'-Methyl-3-[4-(Methylsulfonyl)phenyl]-2,3'-bipyridine 1'-Oxide 4-methylsulfinylbenzoate 4-Methylsulphonylacetophenone Etoricoxib Impurity 11 4-Methylthiophenylacetic acid Etoricoxib Impurity 13 Etoricoxib Impurity 8 4-(methylsulfinyl)benzeneacetic acid Etoricoxib impurity Q 2-Chloro-1,3-bis(dimentylamino)trimethinium hexafluorophosphate 6-Methylpyridine-3-carboxylic acid Etoricoxib Impurity M Etoricoxib Impurity 39 Etoricoxib Impurity 7

1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone

1-(6-Methyl-3-pyridinyl)-2-[4-(Methylthio)phenyl]-ethanone

1-(6-Methyl-3-pyridinyl)-2-[4-(methylsulfanyl)phenyl]ethanone

Etoricoxib Intermediate 1

1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone

Etoricoxib impurity 14/1-(6-Methylpyridin-3-yl)-2-[4-(methylthio)phenyl]ethanone

Ethanone, 1-?(6-?methyl-?3-?pyridinyl)?-?2-?[4-?(methylthio)?phenyl]?-

1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethan-1-one

221615-72-1

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