Fenazaquin
- Product Name
- Fenazaquin
- CAS No.
- 120928-09-8
- Chemical Name
- Fenazaquin
- Synonyms
- el436;MAGISTER;XDE 436);FENAZAQUIN;phenethoxy);AFenazaquin;Fenazaquin 0.1;4-(4-(tert-Butyl);Fenazaquin (EL436;C13441000 Fenazaquin
- CBNumber
- CB2350051
- Molecular Formula
- C20H22N2O
- Formula Weight
- 306.4
- MOL File
- 120928-09-8.mol
Fenazaquin Property
- Melting point:
- 70-71° (Dreikorn); mp 77.5-80.0° (Gambie)
- Boiling point:
- 447.01°C (rough estimate)
- Density
- 1.0970 (rough estimate)
- vapor pressure
- 3.4 x l0-6 Pa (25 °C)
- refractive index
- 1.5700 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- Water Solubility
- 0.102 mg l-1 (20 °C, pH 7)
- pka
- 2.88±0.30(Predicted)
- form
- solid
- color
- White to off-white
- BRN
- 8331263
- Henry's Law Constant
- 2.1×102 mol/(m3Pa) at 25℃, Duchowicz et al. (2020)
- Major Application
- agriculture
environmental - InChI
- 1S/C20H22N2O/c1-20(2,3)16-10-8-15(9-11-16)12-13-23-19-17-6-4-5-7-18(17)21-14-22-19/h4-11,14H,12-13H2,1-3H3
- InChIKey
- DMYHGDXADUDKCQ-UHFFFAOYSA-N
- SMILES
- CC(C)(C)c1ccc(CCOc2ncnc3ccccc23)cc1
- LogP
- 5.510
- CAS DataBase Reference
- 120928-09-8(CAS DataBase Reference)
- EPA Substance Registry System
- Fenazaquin (120928-09-8)
Safety
- Hazard Codes
- T,N
- Risk Statements
- 20-25-50/53
- Safety Statements
- 37-45-60-61
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- VA1382000
- Storage Class
- 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects - Hazard Classifications
- Acute Tox. 3 Oral
Acute Tox. 4 Inhalation
Aquatic Acute 1
Aquatic Chronic 1 - Hazardous Substances Data
- 120928-09-8(Hazardous Substances Data)
- Toxicity
- LD50 orally in rats, mice (mg/kg): 134, 1480; dermally in rabbits (mg/kg): >5000; LC50 (96 hr) in bluegill, trout (mg/l): 34.1, 3.8 (Longhurst)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H332Harmful if inhaled
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 31635
- Product name
- Fenazaquin
- Purity
- PESTANAL
- Packaging
- 100mg
- Price
- $158
- Updated
- 2026/03/19
- Product number
- F245740
- Product name
- Fenazaquin
- Packaging
- 100mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- F245740
- Product name
- Fenazaquin
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- 40437
- Product name
- Fenazaquin
- Packaging
- 250mg
- Price
- $620
- Updated
- 2021/12/16
- Product number
- PST0000091
- Product name
- FENAZAQUIN
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $622.15
- Updated
- 2021/12/16
Fenazaquin Chemical Properties,Usage,Production
Uses
Fenazaquin is a non-systemic acaricide/insecticide used widely in controlling mites and other related pests in fruits, vegetables and tea.
Uses
Fenazaquin is an acaricide mainly used for control of mites (Eutetranychus, Panonychus and Tetranychus spp.) on pome and citrus fruits and glasshouse-grown ornamental plants.
Uses
Acaricide and insecticide.
Definition
ChEBI: Fenazaquin is a member of quinazolines. It has a role as an acaricide and a mitochondrial NADH:ubiquinone reductase inhibitor.
Synthesis
A novel method for the preparation of the acaricide fenazaquin:
1) 4-tert-butylphenethyl alcohol (5 g, 28.0 mmol) and THF (200 mL) were added in a 500 ml reactor, and PPh3 (8.80 g, 33.7 mmol) was added in a single addition and N-bromosubstituted butylenediimide (NBS, 6.0 g, 33.7 mmol) was added in batches sequentially, and the reaction solution was stirred at 25C for For 4h, the tetrahydrofuran in the reaction solution was spun dry, dissolved in dichloromethane, washed twice with 150 ml of water, washed once with 150 ml of saturated saline, and separated by column chromatography (petroleum ether: ethyl acetate = 10:1) to give compound 2-(4-tert-butylphenyl)ethyl bromide 5.8 g in 85.8% yield.
2) In a 500mL four-port reactor equipped with a stirrer, a thermometer and a dropping funnel, 4-hydroxyquinazoline (3.5 g, 24.0 mmol) and 200 ml of dichloromethane were added, and the reaction was carried out under stirring at a controlled temperature of 25C with dropwise addition of 50 ml of dichloromethane solution of 2-(4-tert-butylphenyl)ethyl bromide (5.8 g, 24.0 mmol), and the drop was completed in about 1h, and then the reaction was Raise to 40 reaction 3h, add 400mL of water, separation of the organic layer, the aqueous layer was extracted with 2× 50mL of dichloromethane, combined organic layer. Concentrated under reduced pressure, the crude product was recrystallized from n-hexane to obtain a white solid 5.88g, melting point 72-74 , content 98.1%, yield 80%.
Metabolic pathway
Fenazaquin is a lipophilic compound and hence is immobile in soils and is not translocated in plants. The main pathways of metabolism involve cleavage of the bridging group between the quinazoline and phenyl rings, oxidation of the tert-butyl sustituent and of the heterocyclic portion of the quinazoline ring and cleavage of that ring. Most of the information is taken from a pamphlet produced by the manufacturer of the compound in which full experimental details were not given (DowElanco, 1993).
Degradation
Fenazaquin is hydrolysed under acidic conditions but the rate is slow under neutral and alkaline conditions. Half-lives were 8,442 and 584 days (22 °C) at pH values of 5, 7 and 9, respectively. Hydrolysis occurs by cleavage of the ether linkage to form quinazolin-2-ol (2) and an alcohol (3) as shown in Scheme 1. The major route of degradation in aquatic environments is by photolysis, the main products (2 and 3) being formed by cleavage of the ether lmkage and include the alkene (4) (DowElanco, 1993).
Fenazaquin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Fenazaquin manufacturers
- Product
- fenazaquin 120928-09-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 20tons
- Release date
- 2024-08-01
- Product
- Fenazaquin 120928-09-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 tons
- Release date
- 2020-04-27
- Product
- Fenazaquin 120928-09-8
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg, 5kg, 50kg
- Release date
- 2020-01-09