ChemicalBook > CAS DataBase List > Hydantoin

Hydantoin

Product Name
Hydantoin
CAS No.
461-72-3
Chemical Name
Hydantoin
Synonyms
Imidazolidine-2,4-dione;2,4-IMIDAZOLIDINEDIONE;Maine;NSC 922;NSC 9226;HYDANTOIN;GLYCOLYLUREA;Hydantoin>Hydantoin,99%;glycollylurea
CBNumber
CB2352752
Molecular Formula
C3H4N2O2
Formula Weight
100.08
MOL File
461-72-3.mol
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Hydantoin Property

Melting point:
218-220 °C (lit.)
Boiling point:
187.47°C (rough estimate)
Density 
1.4457 (rough estimate)
vapor pressure 
0Pa at 25℃
refractive index 
1.5110 (estimate)
storage temp. 
Store below +30°C.
solubility 
SLIGHTLY SOLUBLE
pka
pKa 9.1 (Uncertain)
form 
Fine Powder
color 
White to light yellow
Water Solubility 
SLIGHTLY SOLUBLE
Merck 
14,4760
BRN 
110598
LogP
-1.69
CAS DataBase Reference
461-72-3(CAS DataBase Reference)
NIST Chemistry Reference
2,4-Imidazolidinedione(461-72-3)
EPA Substance Registry System
2,4-Imidazolidinedione (461-72-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36/37/39-27-26
WGK Germany 
3
RTECS 
MT8210000
TSCA 
Yes
HS Code 
29332100
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.04511
Product name
Hydantoin
Purity
for synthesis
Packaging
100g
Price
$48.2
Updated
2024/03/01
Sigma-Aldrich
Product number
8.04511
Product name
Hydantoin
Purity
for synthesis
Packaging
500g
Price
$164
Updated
2024/03/01
Sigma-Aldrich
Product number
156361
Product name
Hydantoin
Purity
98%
Packaging
100g
Price
$41.7
Updated
2024/03/01
Sigma-Aldrich
Product number
156361
Product name
Hydantoin
Purity
98%
Packaging
500g
Price
$122
Updated
2024/03/01
TCI Chemical
Product number
H0167
Product name
Hydantoin
Purity
>99.0%(T)
Packaging
25g
Price
$23
Updated
2024/03/01
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Hydantoin Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

The product has been used as a substrate (at 40 °C and pH 9.0) to determine the D-hydantoinase activity in adzuki bean extract.

Uses

Reactant for synthesis of: N-benzyl aplysinopsin analogs as anticancer agents, D-glutamic acid based inhibitors, Antidiabetic chromonyl-2,4-thiazolidinediones, GSK-3β, inhibitors with brain permeability, Thiazolidinedione derivatives as 15-PGDH inhibitors, and Radio-sensitizing agents.

Definition

ChEBI: Hydantoin is an imidazolidine-2,4-dione.

Pharmaceutical Applications

Control of generalized convulsive status epilepticus; prevention and treatment of seizures during neurosurgery; short-term substitute for oral phenytoin.

Mechanism of action

Hydantoins are a class of drugs mainly used to treat seizures (anticonvulsant or antiepileptic drugs). Hydantoins reduce seizures by targeting the sodium channel present throughout the nerves. Activation of sodium channels results in the conduction of electrical impulses and the release of neurotransmitters. It could stabilise neuronal membranes by decreasing sodium and calcium ion influx into the neurons. Also decreases post-tetanic potentiation and repetitive discharge.

Pharmacokinetics

Completely absorbed after IM administration. Protein binding: 95%–99%. Rapidly and completely hydrolyzed to phenytoin after IM or IV administration. Time of complete conversion to phenytoin: 4 hr after IM injection; 2 hr after IV infusion. Half-life: 8–15 min (for conversion to phenytoin).

Hydantoin Preparation Products And Raw materials

Raw materials

Orotic acid SYNTHETIC RESIN

Preparation Products

(S)-2-AMINO-3-(6-METHOXY-1H-INDOL-3-YL)-PROPIONIC ACID 5-METHOXY-DL-TRYPTOPHAN L-Valine S-α-cyano-3-phenoxy benzyl alcohol Glycine BANISTERINE MONOHYDRATE OROTIC ACID MONOHYDRATE
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Hydantoin Suppliers

Americas 1 Belgium 3 Canada 3 China 326 Europe 3 Germany 11 India 22 Italy 1 Japan 4 Slovakia 1 South Korea 1 Switzerland 3 Ukraine 1 United Kingdom 14 United States 54 Global 448
Pure Chemistry Scientific Inc.
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View Lastest Price from Hydantoin manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Hydantoin 461-72-3
Price
US $99.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-16
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Hydantoin 461-72-3
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-21
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Hydantoin 461-72-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-12

461-72-3, HydantoinRelated Search:

Imidazolidinyl urea N-Vinyl-2-pyrrolidone Polyvinylpyrrolidone 1,3-Dibromo-5,5-dimethylhydantoin Ketoprofen Phenytoin sodium Imidazolidine Ethyltrichlorosilane tert-Butyl acetate Abiraterone acetate Ethylmagnesium bromide 2-Imidazolidone dehydroleucine 5 - (1-hydroxy-2-methylpropyl) hydantoin 4-methyl-2-oxopentadide 3-methyl-2-oxopentadide Iprodione Halogenated hydantoin

  • 2,4-IMIDAZOLIDINEDIONE
  • 2,4-IMIDAZOLINEDIONE
  • 2,4-(3H,5H)-IMIDAZOLEDIONE
  • Imidazolidine-2,4-dione
  • HYDANTOIN
  • GLYCOLYLUREA
  • 2-hydroxy-2-imidazolin-4(or5)-on
  • imidazole-2,4-dione
  • 2-Imidazolin-4(or 5)-one, 2-hydroxy-
  • Imidazole-2,4(3H,5H)-dione
  • Hydantoin,99%
  • NSC 922
  • glycollylurea
  • 2,4-Imidazolidinedione 、2-hydroxy-2-imidazolin-4(or 5)-on 、glycolylurea 、hydantoin
  • NSC 9226
  • 2,5-Imidazolidinedione
  • Imidazolidine-2,5-dione
  • Glycolylurea 2,4-Imidazolidinedione
  • Hydantoin, 99% 100GR
  • HYDANTOIN FOR SYNTHESIS 100 G
  • HYDANTOIN FOR SYNTHESIS 500 G
  • Hydantoin , 99.0%(T)
  • CHEMICAL - HYDANTOIN LIKE COMPOUND - (DT
  • Hydantoin&gt
  • Maine
  • dimethyl-substituted hydantoin
  • 461-72-3
  • C3H4N2O2
  • Heterocyclic Building Blocks
  • Imidazolines/Imidazolidines
  • Building Blocks
  • Building Blocks
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Chemical Amines
  • Amines
  • Heterocycles
  • Building Blocks
  • Heterocyclic Building Blocks
  • Imidazolines/Imidazolidines
  • FINE Chemical & INTERMEDIATES
  • Pharmaceutical Intermediates
  • bc0001
  • 461-72-3