ChemicalBook > CAS DataBase List > 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

Product Name
6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
CAS No.
91523-50-1
Chemical Name
6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
Synonyms
6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carbox;6-Hydroxy-1,2,3,4-tetrahydro-sioquinoline-1-carboxylicacid;6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-caeboxylic acid;6-HYDROXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID;1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-6-hydroxy-;6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxcarboxylicacid;6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid, CAS 91523-50-1;6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-16-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid-carboxylic acid
CBNumber
CB2353663
Molecular Formula
C10H11NO3
Formula Weight
193.2
MOL File
91523-50-1.mol
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6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid Property

Boiling point:
458.1±45.0 °C(Predicted)
Density 
1.351±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
2.05±0.20(Predicted)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
H999960
Product name
6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylicAcid
Packaging
100mg
Price
$60
Updated
2021/12/16
Ark Pharm
Product number
P000339517
Product name
6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
Purity
97%
Packaging
250mg
Price
$47
Updated
2021/12/16
Ark Pharm
Product number
P000339517
Product name
6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
Purity
97%
Packaging
1g
Price
$116
Updated
2021/12/16
Ark Pharm
Product number
P000339517
Product name
6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
Purity
97%
Packaging
5g
Price
$460
Updated
2021/12/16
AK Scientific
Product number
5388AC
Product name
6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylicacid
Packaging
5g
Price
$593
Updated
2021/12/16
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6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid Chemical Properties,Usage,Production

Uses

6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic Acid is useful chemical in the studying of proline containing peptides as caspase-2 inhibitors.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 27, p. 1321, 1984 DOI: 10.1021/jm00376a017

Synthesis

588-05-6

298-12-4

91523-50-1

GENERAL PROCEDURE: A solution of 2-oxoacetic acid monohydrate (2.0 g, 22 mmol) in ethanol (10 mL) was added slowly and dropwise to a denatured ethanol (70 mL) solution of 3-hydroxyphenylethylamine hydrochloride (3.08 g, 22.5 mmol) at 4 °C. Immediately after the dropwise addition, a white precipitate was observed to be generated. The ice bath was removed and the reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the white solid product 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (3.1 g, 73% yield) was collected by filtration. The product was analyzed by LC/MS (electrospray, positive ion mode) and showed m/z 194 ([M+H]+).

References

[1] Journal of Medicinal Chemistry, 1984, vol. 27, # 10, p. 1321 - 1325
[2] Patent: US6649606, 2003, B1. Location in patent: Page/Page column 38
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 1, p. 47 - 50
[4] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 7, p. 1799 - 1802

6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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91523-50-1, 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acidRelated Search:

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