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SPHINGOSYLPHOSPHORYLCHOLINE

Product Name
SPHINGOSYLPHOSPHORYLCHOLINE
CAS No.
1670-26-4
Chemical Name
SPHINGOSYLPHOSPHORYLCHOLINE
Synonyms
SPC;MGC119002;D-ERYTHRO-SPC;Lyso SM (d18:1);LYSO-SPHINGOMYELIN;urocortin 3 (stresscopin);Lyso-Sphingomyelin (d18:1);SPHINGOSYLPHOSPHORYLCHOLINE;spingosyl-phosphorylcholine;Sphingenyl-1-phosphorylcholine
CBNumber
CB2356664
Molecular Formula
C23H49N2O5P
Formula Weight
464.62
MOL File
1670-26-4.mol
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SPHINGOSYLPHOSPHORYLCHOLINE Property

Melting point:
90-102°C
storage temp. 
-20°C
solubility 
chloroform/methanol (2:1): complete10 mg/ml, clear to slightly hazy, colorless to light yellow
form 
powder
color 
light yellow
BRN 
7342520
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Safety

WGK Germany 
3
F 
1-8-10
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10007947
Product name
Lyso-Sphingomyelin (d18:1)
Purity
≥98%
Packaging
1mg
Price
$90
Updated
2024/03/01
Cayman Chemical
Product number
10007947
Product name
Lyso-Sphingomyelin (d18:1)
Purity
≥98%
Packaging
5mg
Price
$401
Updated
2024/03/01
Sigma-Aldrich
Product number
S4257
Product name
Sphingosylphosphoryl-choline
Purity
≥98%, powder
Packaging
10mg
Price
$332
Updated
2024/03/01
Sigma-Aldrich
Product number
S4257
Product name
Sphingosylphosphoryl-choline
Purity
≥98%, powder
Packaging
25mg
Price
$473.4
Updated
2024/03/01
Sigma-Aldrich
Product number
567735
Product name
Sphingosylphosphoryl-choline
Packaging
10mg
Price
$535
Updated
2024/03/01
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SPHINGOSYLPHOSPHORYLCHOLINE Chemical Properties,Usage,Production

Chemical Properties

Yellowish Waxy Solid

Uses

Involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction.

Uses

Neurotrophic effects of Sphingosylphosphorylcholine were studied in cerebellar granule neurons of mice and PC-12 cells.

Uses

Lyso SM (d18:1) has been used:

  • to study its effect on the skeletal muscle ryanodine receptor (RyR1), in the presence and absence of calmodulin through single channel recordings in planar lipid bilayers
  • as an inhibitor of Ca2+ sensor calmodulin (CaM)
  • as a standard in circular dichroism (CD) spectroscopy to determine lipid selectivity of the lipid-peptide interactions

Definition

ChEBI: Sphingosine-1-phosphocholine is a phosphosphingolipid consisting of sphingosine having a phosphocholine moiety attached to its primary hydroxyl group. It is a phosphosphingolipid, a member of phosphocholines and an ammonium betaine. It is functionally related to a sphingosine. It is a conjugate base of a sphingosylphosphocholine acid and a sphingosine-1-phosphocholine(1+).

General Description

Lyso SM (d18:1), also known as sphingosylphosphorylcholine (SPC), is a bioactive lipid molecule. This lysophospholipid is present in normal blood plasma, ascites and various tissues.

Biochem/physiol Actions

Sphingosylphosphorylcholine (SPC) is a bioactive lipid that mediates intracellular and extracellular signaling. It mobilizes Ca2+ from intracellular stores via an IP3-independent pathway. It stimulates the production of CCL2 that may contribute to development of atherosclerosis. SPC is a ligand for endothelial differentiation gene receptor 3 (EDG3).

SPHINGOSYLPHOSPHORYLCHOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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SPHINGOSYLPHOSPHORYLCHOLINE Suppliers

Canada 1 China 45 Germany 2 India 1 Switzerland 1 United Kingdom 3 United States 19 Global 72
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
Yichang Zhongyitai Trading Co., Ltd.
Tel
0717-6449896 13886658719
Fax
0717-6558598
Email
root@zhongyitai.com
Country
China
ProdList
1977
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58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Alfa Chemistry
Tel
1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
Country
United States
ProdList
9171
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60
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
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View Lastest Price from SPHINGOSYLPHOSPHORYLCHOLINE manufacturers

Career Henan Chemical Co
Product
SPHINGOSYLPHOSPHORYLCHOLINE 1670-26-4
Price
US $1.00/KG
Min. Order
1KG
Purity
98%-99.9%
Supply Ability
200kg
Release date
2020-01-10

1670-26-4, SPHINGOSYLPHOSPHORYLCHOLINERelated Search:

SPHINGOSYLPHOSPHORYLCHOLINE N-OCTADECANOYLSPHING-OSYLPHOSPHORYLCHOLINE 6-((N-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)AMINO)-HEXANOYL)SPHINGOSYL PHOSPHOCHOLINE SPHINGOMYELIN (BOVINE), [CHOLINE METHYL-14C] N-ACETYL-SPHINGOSYLPHOSPHORYLCHOLINE N-DODECANOYL-NBD-SPHINGOSYLPHOSPHORYLCHOLINE,N-C12-NBD-SPHINGOSYLPHOSPHORYLCHOLINE Sphingosylphosphorylcholine?(lyso-sphingomyelin),Sphingosylphosphorylcholine?(lyso-sphingomyelin) SPHINGOMYELIN AZIDOPHOSPHORYLSPHINGOSYLCHOLINE 3-O-TERT-BUTYLDIMETHYLSILYL-D-ERYTHRO-SPHINGOSYLPHOSPHORYLCHOLINE LYSOSPHINGOMYELIN, [CHOLINE METHYL-3H] N-Palmitoyl-1-13C-Sphingosylphosphorylcholine N-HEPTADECANOYL-SPHINGOSYLPHOSPHORYLCHOLINE SPHINGOSYLPHOSPHORYLCHOLINE CHLORIDE N-BOC-[N-3-O-ISOPROPYLIDENE]-D-ERYTHRO-SPHINGOSYLPHOSPHORYLCHOLINE N-4-nitrobenzo-2-oxa-1,3-diazoleaminocaproyl sphingosylphosphorylcholine N-(12-((1-pyrenesulfonyl)amido)dodecanoyl)sphingosylphosphorylcholine L-THREO-SPHINGOSYLPHOSPHORYLCHOLINE

  • LYSO-SPHINGOMYELIN
  • D-ERYTHRO-SPC
  • D-ERYTHRO-SPHINGOSYLPHOSPHORYLCHOLINE
  • SPHINGOSYLPHOSPHORYLCHOLINE
  • SPHINGOSYLPHOSPHORYLCHOLINE, D-ERYTHRO
  • Sphingosylphosphoryl-choline - CAS 1670-26-4 - Calbiochem
  • 2-[[[(2-amino-3-hydroxy-4-octadecenyl)oxy]hydroxy-phosphinyl]oxy]-n,n,n-trimethylethanaminium inner salt
  • (2S,3R,4E)-2-Amino-4-octadecene-3-hydroxy-1-phosphocholine
  • D-erythro-Sphingosine phosphocholine
  • Lyso SM (d18:1)
  • Anti-UCN3 antibody produced in goat
  • MGC119002
  • urocortin 3 (stresscopin)
  • SPHINGOSYLPHOSPHORYLCHOLINE;LYSO SM (D18:1)
  • Lyso-Sphingomyelin (d18:1)
  • D-erythro-Sphingosylphosphorylcholine (Synthetic)
  • 2-[[[[(2S,3R,4E)-2-AMino-3-hydroxy-4-octadecen-1-yl]oxy]hydroxyphosphinyl]oxy]-N,N,N-triMethyl-ethanaMiniuM
  • Sphingenyl-1-phosphorylcholine
  • spingosyl-phosphorylcholine
  • Lysosphingomyelin, 2-[[[(2-Amino-3-hydroxy-4-octadecenyl)oxy]hydroxy-phosphinyl]oxy]-N,N,N-trimethylethanaminium inner salt
  • SPC
  • D-erythro Lysosphingomyelin (d18:1)
  • 1670-26-4
  • C23H49N2O5P
  • Lipids
  • Phosphosphingolipids
  • Sphingolipids
  • Ceramide phosphocholines (sphingomyelins)
  • BioChemical
  • Biochemicals and Reagents
  • Activators
  • Fatty Acid Derivatives & Lipids
  • Glycerols
  • Inhibitors
  • Protein Kinase Inhibitors and Activators
  • Chemical Activators